For research use only.

Catalog No.S3894 Synonyms: CAG, TA-65, Cyclogalegigenin, Astramembrangenin

1 publication

Cycloastragenol Chemical Structure

CAS No. 84605-18-5

Cycloastragenol (CAG, TA-65, Cyclogalegigenin, Astramembrangenin) is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells.

Selleck's Cycloastragenol has been cited by 1 publication

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Description Cycloastragenol (CAG, TA-65, Cyclogalegigenin, Astramembrangenin) is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells.
telomerase [1]
In vitro

Cycloastragenol stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. It induces telomerase activity and cAMP response element binding (CREB) activation in PC12 cells and primary neurons. CAG treatment not only induces the expression of bcl2, a CREB-regulated gene, but also the expression of telomerase reverse transcriptase in primary cortical neurons[1]. Cycloastragenol rapidly passes through the Caco-2 cell monolayer by passive diffusion, once passage through the intestinal epithelium, first-pass intestinal metabolism of Cycloastragenol might occur. Cycloastragenol can undergo extensive metabolism in rat and human liver microsomes[2].

In vivo Oral administration of cycloastragenol (CA) for 7 days attenuates depression-like behavior in experimental mice. Oral bioavailability of cycloastragenol is about 25.70% at 10 mg/kg. Cycloastragenol is excreted through bile and feces and eliminated predominantly by the kidney in rats. It also might exist an enterohepatic circulation of cycloastragenol in rats. Cycloastragenol could be metabolized widely in vivo in rat. For oral administration the mean Tmax at 10 mg/kg, 20 mg/kg, and 40 mg/kg is 2.06±0.58 h, 1.48±0.36 h, and 2.35± 1.17 h. The t1/2 is 5.23±1.55 h, 7.33±3.03 h, and 6.06± 3.42 h, respectively. The mean absorption time of CA at 10 mg/kg is 5.70± 1.62 h; the poor absorption could be caused by the low solubility. The pharmacokinetic parameters show no significant differences among the groups of 10, 20, and 40 mg/kg except for Cmax and AUC[2].


Cell Research:[1]
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  • Cell lines: HEKn cells, PC12 cells
  • Concentrations: --
  • Incubation Time: 24 h
  • Method: HEKn cells (population doubling time: 3-6 days), PC12 cells (passage No.: 12-18), cultured primary cortical, and hippocampal neurons [12 days in vitro (DIV)] are treated with CAG for 24 h. Total cell lysates are then collected by using the lysis buffer provided in the real-time quantitative telomeric repeat amplification protocol (RQ-TRAP) assay kit. Telomerase activity is determined by using an ABI Prism 7000.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: male ICR mice
  • Dosages: 100 mg/kg
  • Administration: by oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 98 mg/mL (199.7 mM)

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Chemical Information

Molecular Weight 490.72


CAS No. 84605-18-5
Storage powder
in solvent
Synonyms CAG, TA-65, Cyclogalegigenin, Astramembrangenin
Smiles CC1(C(CCC23C1C(CC4C2(C3)CCC5(C4(CC(C5C6(CCC(O6)C(C)(C)O)C)O)C)C)O)O)C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04890704 Completed Drug: Curcuminoid|Drug: Placebo Acute Kidney Injury|Contrast Media Toxicity|Curcuminoid|Chronic Kidney Diseases Bangkok Metropolitan Administration Medical College and Vajira Hospital October 1 2018 Early Phase 1
NCT02711384 Completed -- Coronary Disease|Coronary Artery Disease Instituto Dante Pazzanese de Cardiologia March 25 2018 --
NCT03452436 Completed -- Cancer-related Cognitive Impairment University of Aarhus|Aarhus University Hospital February 12 2018 --
NCT03445728 Enrolling by invitation Drug: Nicorandil|Other: Placebo Myocardial Infarction|Percutaneous Coronary Intervention|Nicorandil Chinese PLA General Hospital February 24 2018 Phase 4
NCT03479593 Recruiting Diagnostic Test: CMR and OCT in NSTEMI patients with MVD NSTEMI - Non-ST Segment Elevation MI|Multi Vessel Coronary Artery Disease Rigshospitalet Denmark January 10 2018 --

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID