Home Neuronal Signaling ADC Cytotoxin inhibitor - Dopamine Receptor inhibitor Tetrahydropalmatine hydrochloride

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Tetrahydropalmatine hydrochloride ADC Cytotoxin inhibitor

Cat.No.S3854

Tetrahydropalmatine (THP, Gindarine, 1-Tetrahydropalmitine) is an isoquinoline alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda. It is a potent muscle relaxant. Tetrahydropalmatine hydrochloride acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats.
Tetrahydropalmatine hydrochloride ADC Cytotoxin inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 391.89

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S385401 DMSO]12 mg/mL]false]]]false]]]false Purity: 99.74%
99.74

Chemical Information, Storage & Stability

Molecular Weight 391.89 Formula

C21H25NO4.HCl

 Storage (From the date of receipt)
CAS No. 6024-85-7 -- Storage of Stock Solutions

Synonyms Gindarine hydrochloride, 1-Tetrahydropalmitine HCl Smiles COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC.Cl

Solubility

In vitro
Batch:

DMSO : 12 mg/mL (30.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

In vitro
Tetrahydropalmatine inhibits the LPSinduced production of COX-2 protein and mRNA in a dose-dependent manner. It suppresses activation of the NF-kB signaling pathway, which results in regulation of IL-8 expression and specifically blocks the ERK1=2 and p38 MAPK signaling pathways[1]. L-THP results in p53 independent apoptosis via down-regulating XIAP protein by inhibiting MDM2 associated with proteasome-dependent pathway and increased sensitivity of EU-4 cells against doxorubicin. L-THP causes activation of caspase and resulted in apoptosis[2]. l-THP possesses a blocking effect on dopamine D1 and D2 receptors and voltage-sensitive Ca2+ channels[3].
In vivo
l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization[3].
References

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