Oridonin (NSC-250682)

Catalog No.S2335 Synonyms: Isodonol, Rubescenin

For research use only.

Oridonin (Isodonol, Rubescenin, NSC-250682), a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibits AKT1 and AKT2 kinase activity with IC50 of 8.4 μM and 8.9 μM, respectively.

Oridonin (NSC-250682) Chemical Structure

CAS No. 28957-04-2

Selleck's Oridonin (NSC-250682) has been cited by 17 publications

Purity & Quality Control

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Biological Activity

Description Oridonin (Isodonol, Rubescenin, NSC-250682), a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibits AKT1 and AKT2 kinase activity with IC50 of 8.4 μM and 8.9 μM, respectively.
Targets
Akt1 [5]
(Cell-free assay)
Akt2 [5]
(Cell-free assay)
8.4 μM 8.9 μM
In vitro

Oridonin effectively inhibites the proliferation of a wide variety of cancer cells including those from prostate (LNCaP, DU145, PC3), breast (MCF-7, MDA-MB231), non-small cell lung (NSCL) (NCI-H520, NCI-H460, NCI-H1299) cancers, acute promyelocytic leukemia (NB4), and glioblastoma multiforme (U118, U138) with ED50s ranging from 1.8 to 7.5 μg/ml. [1] The antitumor activities of Oridonin may due to its inhibitory effects on NF-kappaB and MAPKs signal pathways. [2] [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HL60 NWrZWmRES3m2b4TvfIlkcXS7IHHzd4F6 NVLwe3pTPDhiaILz MoTBR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gTGw3OCClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUKuOe69VQ>? M33yZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEG5PFcyLz5{M{ixPVg4OTxxYU6=
RAW264.7 MXnBcpRqcW6obHHtcYF1d3K7IHHzd4F6 MlTzNVghcHK| NX[ySGN4SW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJI5qfHKrYzDvfIll\SCycn;keYN1cW:wIHHmeIVzKDF6IHjyd{BjgSCJcnnld5MhdWW2aH;kMEBKSzVyPUWuNu69VQ>? M3q3NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEG5PFcyLz5{M{ixPVg4OTxxYU6=
K562 MnP2RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NF3YXIk4OiCqcoO= MVnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEt3NkKgZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF01NjN|zszN MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF4NUezPEc,OjhzNkW3N|g9N2F-
Bel7402 MUTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MoPVO|IhcHK| NWTvbldbSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDC[Yw4PDB{IHPlcIx{KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9OU41Oc7:TR?= NIrjOJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG2OVc{QCd-MkixOlU4Ozh:L3G+
MGC803 M4\VZ2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MYO3NkBpenN? NHnVdJNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3HR|gxOyClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUmuNFbPxE1? NUjnTnBTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOlU4OzhpPkK4NVY2PzN6PD;hQi=>
KB/CP4 MXzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MYe0PEBpenN? NWDYbWF{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLRk9EWDRiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2xNE45|ryP MoXoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzNkW3N|goRjJ6MU[1O|M5RC:jPh?=
KB-3-1 NITUOZpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NIjRPVY1QCCqcoO= NWTyNnl5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDLRk0{NTFiY3XscJMh[W[2ZYKgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2xN{4zPM7:TR?= MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF4NUezPEc,OjhzNkW3N|g9N2F-
BEL7404/CP20 MorCRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MXS0PEBpenN? MVHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKHTEe0NFQwS1B{MDDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVE4NjF5zszN NHL0eok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG2OVc{QCd-MkixOlU4Ozh:L3G+
MCF7 NX31ZZM5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Mlv3O|IhcHK| NV:3[2lkSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNR2Y4KGOnbHzzJIFnfGW{IEeyJIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MUeuPFnPxE1? MmDOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzNkW3N|goRjJ6MU[1O|M5RC:jPh?=
Bel7404 MYfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NYjJOG9sPDhiaILz NUSyc3hsSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDC[Yw4PDB2IHPlcIx{KGGodHXyJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9NVcvQTMQvF2= M2rsT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MU[1O|M5Lz5{OEG2OVc{QDxxYU6=
NCI-H460 NH\TSVRCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NGTOWVM1QCCqcoO= MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3IOFYxKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkCuOVHPxE1? NIfnbos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG2OVc{QCd-MkixOlU4Ozh:L3G+
NCI-H460/MX20 NVW4Tm9PSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MXy0PEBpenN? NFywb2lCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JPDZyL13YNlAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{NT64Ou69VQ>? M3rhT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MU[1O|M5Lz5{OEG2OVc{QDxxYU6=
K562 MlfKRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NGqydYw4OiCqcoO= Ml;tRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNNU[yJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUSuOlTPxE1? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl{MUe1O{c,OzB7MkG3OVc9N2F-
SGC7901 NWK0cm9RSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NXPiRVFNPzJiaILz MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOJQ{e5NFEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9O{4yO87:TR?= M1roZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUKxO|U4Lz5|MEmyNVc2PzxxYU6=
Bel7402 MWnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M1PvfFczKGi{cx?= MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEKnbEe0NFIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9O{45Pc7:TR?= M33vVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUKxO|U4Lz5|MEmyNVc2PzxxYU6=
HL60 NX:yeGZFSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M2XZd|czKGi{cx?= M4rreWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME25MlQ3|ryP MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl{MUe1O{c,OzB7MkG3OVc9N2F-
PC3 M4TYT2FvfGmycn;sbYZmemG2aY\lJIF{e2G7 MWO3NkBpenN? NWflXnY5SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NVAvODgQvF2= M{Prc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUKxO|U4Lz5|MEmyNVc2PzxxYU6=
A549 NVPDVow6SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NYfBN3NjPzJiaILz MkDxRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDNUS5JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUG4MlE2|ryP NXTtbWVzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5NlE4PTdpPkOwPVIyPzV5PD;hQi=>
L02 M1LSb2N6fG:2b4jpZ4l1gSCjc4PhfS=> NFX0OW84OiCqcoO= NF\ifGlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBNODJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:OTlwNUROwG0> NEPpPYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEmyNVc2Pyd-M{C5NlE4PTd:L3G+
HCT116 Mk[1RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? M1\UfVQ5KGi{cx?= M1y3T2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFPUNVE3KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCrbnP1ZoF1\WRiZn;yJFQ5KGi{czDifUBOXFRiYYPzZZktKEmFNUC9Ok45PM7:TR?= NFHYW3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEm4NVEyOyd-M{C5PFEyOTN:L3G+
L02 NYT0eJdbS3m2b4TvfIlkcXS7IHHzd4F6 MmDDOFghcHK| Mo\UR5l1d3SxeHnjbZR6KGmwIHj1cYFvKExyMjDj[YxteyCjc4Pld5Nm\CCjczDy[YR2[3Srb36gbY4h[2WubDD2bYFjcWyrdImgbY5kfWKjdHXkJIZweiB2ODDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTZwOUhOwG0> MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl6MUGxN{c,OzB7OEGxNVM9N2F-
Bel7402 MlrxRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXPqNYpmPDhiaILz M1;5UWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQnXsO|QxOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliaX7jeYJifGWmIH\vdkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVkvPToQvF2= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl6MUGxN{c,OzB7OEGxNVM9N2F-
MCF7 M1m1ZWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NXPpV2lZPDhiaILz MkDYRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBqdmO3YnH0[YQh\m:{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MUeuOVbPxE1? MoXNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB7OEGxNVMoRjNyOUixNVE{RC:jPh?=
MDA-MB-231 MULBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M3rTTFQ5KGi{cx?= MWjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0zOzFiY3XscJMhcW6ldXLheIVlKG[xcjC0PEBpenNiYomgUXRVKGG|c3H5MEBGSzVyPUK5MlTPxE1? MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl6MUGxN{c,OzB7OEGxNVM9N2F-
HCT116 NYLFV2oyS2WubDDjfYNt\SCjcoLld5Qh[XO|YYm= M1HJSlMhfU1? NWWxUIR4OjRiaILz NW\y[G9UUW6mdXP0bY9vKGmwIHPlcIwh[3mlbHWgZZJz\XO2IHnuJIh2dWGwIFjDWFEyPiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIHnuJIN6[2yrbjDBJJBzd3SnaX6g[ZhxemW|c3nvckBt\X[nbDDheEA{KHWPIHnuZ5Vj[XSnZDDmc5IhOjRiaILzJIJ6KFenc4Tldo4h[myxdDDhcoFtgXOrcx?= NIfBRpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEm4NVEyOyd-M{C5PFEyOTN:L3G+
HCT116 M3rQZ2NmdGxiY4njcIUh[XK{ZYP0JIF{e2G7 NILMVoM{KHWP NUjqRm9UOjRiaILz NXjuUWMxUW6mdXP0bY9vKGmwIHPlcIwh[3mlbHWgZZJz\XO2IHnuJIh2dWGwIFjDWFEyPiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIHnuJIN6[2yrbjDCNUBxem:2ZXnuJIV5eHKnc4Ppc44hdGW4ZXygZZQhOyC3TTDpcoN2[mG2ZXSg[o9zKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= M{eyclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUixNVE{Lz5|MEm4NVEyOzxxYU6=
HCT116 MYDBdI9xfG:2aXOgZZN{[Xl? NHHUd2syKHWP NH3SPW4zPCCqcoO= MUXJcoR2[3Srb36gc4Yh[XCxcITveIlkKG2xcoDoc4xw\2mlYXygZ4hidmenIHnuJIh2dWGwIFjDWFEyPiClZXzsd{Bie3Onc4Pl[EBieyCub4PzJI9nKG:{aXfpcoFtKG2xcoDoc4xw\3liYYSgNUB2VSCrbnP1ZoF1\WRiZn;yJFI1KGi{czDifUBp[WWvYYTvfJltcW5vZX;zbY4he3SjaX7pcoch[mG|ZXSgcYlkem:|Y3;wbYMhdWW2aH;k MkPwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB7OEGxNVMoRjNyOUixNVE{RC:jPh?=
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HCT116 NXfhbHlkSXCxcITveIlkKGG|c3H5 NFrLO4cyKHWP NXXEUGhtOjRiaILz MoDVTY5lfWO2aX;uJI9nKGGyb4D0c5Rq[yCvb4LwbI9td2erY3HsJINp[W6pZTDpckBpfW2jbjDIR3QyOTZiY3XscJMh[XO|ZYPz[YQh[XNibXXtZpJidmVic3jybY5s[WenIHH0JFEhfU1iaX7jeYJifGWmIH\vdkAzPCCqcoOgZpkhcGGnbXH0c5h6dGmwLXXvd4lvKHO2YXnubY5oKGKjc3XkJI1q[3Kxc3PvdIlkKG2ndHjv[C=> M2\1UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUixNVE{Lz5|MEm4NVEyOzxxYU6=
PLC/PRF/5 NHewcmNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHfNeXY4OiCqcoO= NGDkempCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDMR{9RWkZxNTDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBES0t6IHPlcIx{NCCLQ{WwQVcvPDIQvF2= NV60Z|VPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyNFAzOzhpPkOxNlAxOjN6PD;hQi=>
HepG2 MYnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mn:1O|IhcHK| NVvCWINUSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{BqdmO3YnH0[YQh\m:{IEeyJIhzeyCkeTDDR2s5KGOnbHzzMEBKSzVyPUiuNVLPxE1? M4\jXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkCwNlM5Lz5|MUKwNFI{QDxxYU6=
RPMI8226 NEnQNWxCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1;2OFczKGi{cx?= MXjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFKSTVm4NlI3KGOnbHzzJIlv[3WkYYTl[EBnd3JiN{KgbJJ{KGK7IFPDT|gh[2WubIOsJGlEPTB;OT6yOe69VQ>? NGXCVIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUKwNFI{QCd-M{GyNFAzOzh:L3G+
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A549 NHPyNVhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXf6Z5NXPzJiaILz MXLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF3NEmgZ4VtdHNiaX7jeYJifGWmIH\vdkA4OiCqcoOgZpkhS0ONODDj[YxteyxiSVO1NF0{OC52zszN NXy4UotRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyNFAzOzhpPkOxNlAxOjN6PD;hQi=>
HepG2 MXvGeY5kfGmxbjDhd5NigQ>? M{naXFAvOSC2bzCxJJVO M4DJWlExKGSjeYO= NXXMXXJkUW6qaXLpeIlwdiCxZjDjc4xwdnliZn;ycYF1cW:wIHnuJIh2dWGwIFjldGczKGOnbHzzJIF1KDBwMTD0c{AyKHWPIHnuZ5Vj[XSnZDDmc5IhOTBiZHH5d{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{Bj[XOnZDDtbYNzd3Olb4DpZ{Bu\XSqb3S= NILX[Io9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MUKwNFI{QCd-M{GyNFAzOzh:L3G+
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Bel7402 MUfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NWe4Ung5PzJiaILz NF7rdllCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFLlcFc1ODJiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHHmeIVzKDd{IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:QC5|Md88US=> MnT3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{MEK5PVIoRjNzMkCyPVkzRC:jPh?=
A549 NWL1XmVMSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M2XvZ|czKGi{cx?= M2ftbmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkh[W[2ZYKgO|IhcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2xO{45|ryP NWjQU2JWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyNFI6QTJpPkOxNlAzQTl{PD;hQi=>
L02 Mk[1R5l1d3SxeHnjbZR6KGG|c3H5 MV63NkBpenN? M1PIcmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGwxOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0yQC54ON88US=> NVnzOm5NRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyNFI6QTJpPkOxNlAzQTl{PD;hQi=>
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MGC803 NGnv[5NCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MWK3NkBpenN? NWD1WWpPSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNS2M5ODNiY3XscJMh[XO|ZYPz[YQh[XNicnXkeYN1cW:wIHnuJINmdGxidnnhZoltcXS7IHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KFOUQjDhd5NigSxiSVO1NF0yPC5zM988US=> NYfBWFZIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G0PVQ1PzJpPkOxOFk1PDd{PD;hQi=>
MCF7 NEfTZ2hCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NEOwWWI4OiCqcoO= NEGybFFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME2yNU46P87:TR?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTR7NES3Nkc,OzF2OUS0O|I9N2F-
Assay
Methods Test Index PMID
Western blot BCR-ABL / Myc ; p-AMPK / AMPK / Glut1 / LC3 28128329 28230866
Immunofluorescence HSF1 ; p65 28128329 25886043
Growth inhibition assay Cell viability 26496199
In vivo

LD50: Mice 35-40mg/kg. [4]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 72 mg/mL
(197.56 mM)
Ethanol 28 mg/mL
(76.83 mM)
Water Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
5% DMSO+20%PEG 300+ddH2O
For best results, use promptly after mixing.

12.5mg/ml

Chemical Information

Molecular Weight 364.43
Formula

C20H28O6

CAS No. 28957-04-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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