4-Methylumbelliferone (4-MU)

Catalog No.S2256

For research use only.

4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.

4-Methylumbelliferone (4-MU) Chemical Structure

CAS No. 90-33-5

Selleck's 4-Methylumbelliferone (4-MU) has been cited by 4 Publications

Purity & Quality Control

Related Other Products

Biological Activity

Description 4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
COS1 cells M2mzbGZ2dmO2aX;uJIF{e2G7 M3XlNGFod26rc4TpZ{Bi[3Srdnn0fUB4[XNiZHX0[ZJucW6nZDDpckBEV1NzIHPlcIx{KHS{YX7z[oVkfGWmIIfpeIghT0GOIEStVHBCWiCpYX3tZUBz\WOncITvdkwhTUN3ME2wMlAzOSEQvF2= NVz6cog{OTJ4MUe5NlQ>
CV-1 cells MUfGeY5kfGmxbjDhd5NigQ>? MlfvUYF5cW2jbDDy[ZBwenSncjDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCncn;4bZNwdWVicILvcIln\XKjdH;yJIFkfGm4YYTl[EBz\WOncITvdkBo[W2vYTDHZYw1KGOqaX3ldolkKGmwIITyZY5{cWWwdHz5JJRz[W6|ZnXjeIVlKEOYLUGgZ4VtdHNiYomg[pVv[3Srb37hcEBie3OjeTygSWM2OD1yLkC0N{DPxE1? MofQNVE4OjB6NUS=
COS-1 cells NFHWeVVHfW6ldHnvckBie3OjeR?= M3y0b2lvKH[rdILvJJRz[W6|YXP0bZZifGmxbjDv[kBpfW2jbjDw[ZJwgGm|b33lJJBzd2yrZnXyZZRweiCjY4TpeoF1\WRicnXj[ZB1d3JiZ3HtcYEhdWWjc4Xy[YQhcW5iUGDBVk1ISUx2IHPobY1memmlIFPPV{0yKGOnbHzzMEBGSzVyPUCuNFIh|ryP MYSxNlg4OzVzNx?=
CV-1 cells MY\GeY5kfGmxbjDhd5NigQ>? MnvRRYN1cX[jdHnvckBw\iCyZYLvfIl{d22nIIDyc4xq\mW{YYTvdkBi[3SrdnH0[YQhemWlZYD0c5Ih\2GvbXGgcYVie3W{ZXSgZpkhcW6mdXP0bY9vKG:oIEWwKUBw\iCvYYjpcZVuKGGua3HsbY5mKHCqb4PwbIF1[XOnIHHjeIl3cXS7LDD0doFve2[nY4Tpc44h[XO|YYmgbY4hS1ZvMTDj[YxteyxiRVO1NF0xNjB6OUGzJO69VQ>? M3jMb|k5OzZ4MkC=
CV-1 cells MV;GeY5kfGmxbjDhd5NigQ>? NFjIZYxKdiC4aYTyc{B1emGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBw\iCSZYLvfIl{d22nIIDyc4xq\mW{YYTvdkBi[3SrdnH0[YQhemWlZYD0c5Ih\2GvbXGgLHBRSVJrIHX4dJJme3OnZDDpckBEXi1zIHPlcIx{NCCHQ{WwQVAvODZizszN NGTjT445PTd4OUC3
COS-1 cells NFzJU5VHfW6ldHnvckBie3OjeR?= Mk\VTY4hfmm2cn:gZYdwdmm|dDDhZ5Rqfmm2eTD0[ZN1\WRiZn;yJJRz[W6|YXP0bZZifGmxbjDpckBpfW2jbjDQVGFTKGejbX3hMWdidDRiY3jpcYVzcWNiQ1;TMVEh[2WubIOsJGVEPTB;MD6wNkDPxE1? M1KxVFEzPzJ7Nk[4
CV-1 cells NXvYOno{TnWwY4Tpc44h[XO|YYm= MkDKTY4hfmm2cn:g[ZZidHWjdHnvckBi\2GrboP0JHJZWi2jbIDoZU9RWEGULXfhcY1iKGmwIFPWMVEh[2WubIOgZpkh[2:2cnHud4Zm[3Srb36gZZN{[Xlid3HzJIRmfGW{bXnu[YQtKEWFNUC9NE4{OjVizszN NX3YWnl7OTJ7NUSwOlE>
HepG2 cells M3LiVmZ2dmO2aX;uJIF{e2G7 MXjF[oZm[3SrdnWgZ49v[2WwdILheIlwdiCjZ3HpcpN1KGi3bXHuJHBRSVKpYX3tZUBmgHC{ZYPz[YQhcW5iSHXwS|Ih[2WubIOsJGVEPTB;MD6wN|kh|ryP NFrROWcyPjFyN{G1NC=>
Huh7 cells MmrWSpVv[3Srb36gZZN{[Xl? Mn3ISpVv[3Srb37hcEBi[3Srdnn0fUBifCCqdX3hckBRWEGUIHfhcY1iKGmwIFj1bFch[2WubIOgZpkhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMkKg{txO M4fuSVE3OzZ4NkCx
Huh7 cells MmroSpVv[3Srb36gZZN{[Xl? NXnCbXlHTW[oZXP0JI9vKFCSQWKg[4FudWFidILhcpNi[3SrdnH0bY9vKGGldHn2bZR6KGmwIFj1bFch[2WubIOsJGVEPTB;MD6yNkDPxE1? MkjCNVY1PTFyOEe=
U2OS cells NVzX[29bTnWwY4Tpc44h[XO|YYm= MVvF[oZm[3Rib36gVHBCWmejbX3hJJRz[W6|YXP0bZZifGmxbjDhZ5Rqfmm2eTDpckBWOk:VIHPlcIx{NCCHQ{WwQVAvODNizszN NWjWVlJDOTZ|MEC5OFQ>
CV1 cells NUXPS4J6TnWwY4Tpc44h[XO|YYm= NVPYbHNWXHKjboPhZ5RqfmG2aX;uJI9nKFCSQWLnZY1u[SCrbjDDWlEh[2WubIOsJGVEPTB;MD6wO|Yh|ryP MoLrNVY5OjF5Nkm=
human keratinocytes NGfHPZdRem:uaX\ldoF1cW:wIHHzd4F6 NU[3RnJKSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDr[ZJifGmwb3P5eIV{NCCHQ{WwQVgh|ryP NWnncnV2OTZ6MkG3Olk>
HT29 cell NIXIUotRem:uaX\ldoF1cW:wIHHzd4F6 MkDZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKVEK5JINmdGxibHnu[UwhTUN3ME20OUDPxE1? MnvtNVY5OjF5Nkm=
NIH3T3 cells NULBSm5CTnWwY4Tpc44h[XO|YYm= MXjBZ5Rqfmm2eTDheEBpfW2jbjDQVGFTKGejbX3hJJRz[W6|ZnXjeIVlKGmwIF7JTFNVOyClZXzsd{BjgSCudXPp[oVz[XOnIHHjeIl3cXS7IHHzd4F6NCCHQ{WwQVAvOzJizszN NVXtRnh6OTZ6NUSwPFU>
CV1 cells M{m4[WZ2dmO2aX;uJIF{e2G7 NF\KZ3FVemGwc3HjeIl3[XSrb36gc4YhcHWvYX6gVHBCWmejbX3hJIlvKEOYMTDj[YxteyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NE4{ODhizszN M2DCcVE3QTdyM{mx
Huh7 cells NVu5R5E2TnWwY4Tpc44h[XO|YYm= NGDRSJpC[3Srdnn0fUBifCCqdX3hckBRWEGUIHfhcY1iKGmwIFj1bFch[2WubIOgZpkhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMkKg{txO M3T5eFE4ODN2MUS5
HepG2 cells M4X3XWZ2dmO2aX;uJIF{e2G7 MYDB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGDQRXIh\2GvbXGgbY4h[SCKZYDHNkBk\WyuczDifUBRWEGULVfBUFQhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMUW4JO69VQ>? Mk\NNVY6PzN|NUi=
HepG2 cells MVrGeY5kfGmxbjDhd5NigQ>? NFr3[FVC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVJiZ3HtcYEhcW5iSHXwS|Ih[2WubIOgZpkhWFCDUj3HRWw1KHS{YX7zZYN1cX[jdHnvckBie3OjeTygSWM2OD1yLkG1PO69VQ>? MmD5NVY6Pzl|NEG=
CV1 cells M2DRSWZ2dmO2aX;uJIF{e2G7 NVvqWVB6SWO2aY\peJkh[XRiaIXtZY4hWFCDUnfhcY1iKGmwIFPWNUBk\WyuczygSWM2OD1yLkOwPEDPxE1? MlXFNVcxODV|OUS=
HEK293 cells MnXBSpVv[3Srb36gZZN{[Xl? MXTBZ5Rqfmm2eTDheEBpfW2jbjDh[Ilxd3OnIITpd5N2\SCSUFHSJIdidW2jIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYomgVHBCWi2JQVy0JJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NF0xNjNzIN88US=> MUWxO|M1OzN5MR?=
rat L6 cells NUfhdYVLTnWwY4Tpc44h[XO|YYm= MXfF[oZm[3Rib36g[oF1fHliYXPp[EBwgGmmYYTpc44hcW5icnH0JGw3KGOnbHzzMEBGSzVyPUWg{txO NYTOcXVnOTd|NEOzO|E>
HepG2 cells M16zbGZ2dmO2aX;uJIF{e2G7 NIH4SZVC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKpYX3tZUBqdiCKZYDHNkBk\WyuczDifUBRWEGULVfBUFQhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMEiyJO69VQ>? MlvQNVcyPTdyMUm=
CV1 cells MV\GeY5kfGmxbjDhd5NigQ>? MXXB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGDQRXJidHCqYTDpckBEXjFiY3XscJMh[nliR1HMOEB1emGwc3HjeIl3[XSrb36gZZN{[XliYX\0[ZIhOjRiaILzMEBGSzVyPUOuOFYh|ryP Mk\sNVc2ODd{MkW=
CV1 cells MWrGeY5kfGmxbjDhd5NigQ>? MmLNRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGgbY4hS1ZzIHPlcIx{KGK7IFfBUFQhfHKjboPhZ5RqfmG2aX;uJIF{e2G7IHHmeIVzKDJ2IHjyd{whTUN3ME2wMlA{KM7:TR?= MV6xO|UxPzJ{NR?=
CV1 cells Ml\ZSpVv[3Srb36gZZN{[Xl? MmrCRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGg[ZhxemW|c3XkJIlvKEOYMTDj[YxteyCkeTDy[YNmeHSxcjD0doFve2GldHn2ZZRqd25iYYPzZZktKEWFNUC9NE4{ODhizszN NIXmR3YyQDB{OUG3PC=>
CV1 cells MX;GeY5kfGmxbjDhd5NigQ>? MmOzRYdwdmm|dDDhZ5Rqfmm2eTDheEBRWEGUZ3HtcYEhcW5iQ2[xJINmdGy|IHL5JJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NF0xNjNyODFOwG0> NEDRNoIyPzF{OUeyOS=>
HEK293 cells M2XSSWZ2dmO2aX;uJIF{e2G7 NF7CcodC\2:waYP0JIFkfGm4aYT5JIF1KFCSQWLnZY1u[SC{ZXPldJRweiCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGK7IFfBUFQhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMEO1JO69VQ>? MYqxO|I6OjZyNh?=
NIH3T3 cells M3nkWGZ2dmO2aX;uJIF{e2G7 MXzB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGDQRXJo[W2vYTDlfJBz\XO|ZXSgbY4hVkmKM2SzJINmdGy|IHL5JGdCVDRidILhcpNi[3SrdnH0bY9vKGG|c3H5MEBGSzVyPUCuN|Ih|ryP NIPId4syPzZ{NEe3Oy=>
HEK293 cells M1m3SmZ2dmO2aX;uJIF{e2G7 M1TjcmFod26rc4SgZYN1cX[rdImgZZQhWFCDUnfhcY1iKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[nliR1HMOEB1emGwc3HjeIl3[XSrb36gZZN{[XluIFXDOVA:OC5zOTFOwG0> NVfYU4oxOThyMkmxO|Y>
HEK293 cells M1O4UmZ2dmO2aX;uJIF{e2G7 MXLB[49vcXO2IHHjeIl3cXS7IHH0JHBRSVKpYX3tZUBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJIF{e2W|c3XkJIF{KGGSMjDn[Y5mKGmwZIXjeIlwdixiRVO1NF0xNjF{IN88US=> NVvoXYhpOThyMkmxO|Y>
HEK293 cells Ml7VSpVv[3Srb36gZZN{[Xl? MnXKRYdwdmm|dDDhZ5Rqfmm2eTDheEBRWEGUZ3HtcYEhcW5iSFXLNlk{KGOnbHzzJIJ6KEeDTESgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwQVAvODR3IN88US=> MonRNVgzQTF4NEW=
HepG2 cells MWLGeY5kfGmxbjDhd5NigQ>? MY\B[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGDQRXJidHCqYTDsbYdidmRiYnnu[Ilv\yCmb33hbY4h\XiycnXzd4VlKGmwIHj1cYFvKEincFeyJINmdGy|IHPvMZRz[W6|ZnXjeIVlKHerdHigS4FtPCCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NE4xOzlizszN NYfY[I15OTh6M{W3NVk>
RAW264.7 cells M1;WTmZ2dmO2aX;uJIF{e2G7 NF22[JhUfXCycnXzd4lwdiCxZjDMVHMwUU[QLXfhcY1iNXO2aX31cIF1\WRiTl:gdJJw\HWldHnvckBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczygSWM2OD1zNz61JO69VQ>? M3zETVE5QDB7M{K1
BL21 cells NH\rWWtHfW6ldHnvckBie3OjeR?= NYDGPIdbTGm|cHzhZ4Vu\W62IH;mJJJi\GmxIHzhZoVt\WRiMjjTLU0pOi2kZX76c5ltNXCqZX75cIFucW6xKT2zMZs1NVtzLEGt[Il1emm2aX:tNk0pPS2vZYTofYwuOi2yaHXufYwud3ijen;sMVQugWxrLXX0bI95gV1vcHjlcplthS2ycn;wbY9vcWNiYXPp[EBnem:vIFfTWE1nfXOnZDDoeY1idiCSUFHS[4FudWFiZYjwdoV{e2WmIHnuJGV{[2incnnjbIliKGOxbHmgRmwzOSClZXzsd{BjgSC|Y3nueIltdGG2aX;uJJBzd3irbXn0fUBie3OjeTygSWM2OD1yLkS1JO69VQ>? NIfPOGcyQTN2OUG3Oi=>
BHK21 cells MUPGeY5kfGmxbjDhd5NigQ>? M3rtVGFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gVHBCWmejbX3hJIV5eHKnc4Pl[EBqdiCESFuyNUBk\WyuczDhd5Nme3OnZDDhd{BUTUGSIHHjeIl3cXS7IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwNEWg{txO M{LlOVE6OzR7MUe2
HepG2/C3A cells NIPreZJHfW6ldHnvckBie3OjeR?= M1nFOGFkfGm4YYTpc44hd2ZiaIXtZY4hWFCDUnfhcY1iKGyrZ3Hu[EBjcW6maX7nJIRwdWGrbj3t[YRq[XSnZDD0doFve2O{aYD0bY9v[WxiYXP0bZZqfHliaX6gbJVu[W5iSHXwS|IwSzODIHPlcIx{KGOxLYTyZY5{\mWldHXkJJdqfGhiZoXz[YQhT2GuND3MRmQh[nliY3;0doFve2[nY4Tpc44h[XO|YYmsJGVEPTB;MD6wNFM5KM7:TR?= M2X0RVE4PDB|Nki4
HepG2 cells Mlj3SpVv[3Srb36gZZN{[Xl? NUOzPIQxSWexbnnzeEBi[3Srdnn0fUBifCCSUFHS[4FudWFiZYjwdoV{e2WmIHnuJIh2dWGwIFjldGczKGOnbHzzJIF{e2W|c3XkJIF{KGmwZIXjeIlwdiCxZjDy[YNmeHSxcjD0doFve2GldHn2ZZRqd25iYomgdoVxd3K2ZYKg[4Vv\SCjc4PhfUBz\WyjdHn2[UB1dyClb370do9tNCCHQ{WwQVAvODVizszN NWLJZlJJOTh4MkW1OVk>
COS1 cells M4T6VmZ2dmO2aX;uJIF{e2G7 NHfLdnhC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJJJm[2:vYnnuZY51KFCSQWLnZY1u[SCneIDy[ZN{\WRiaX6gR29UOSClZXzsd{Bkdy2neIDy[ZN{cW6pIFfBUFQh[XO|ZYPz[YQh[XNidILhcpNkemmydHnvcoFtKGGldHn2bZR6KGGodHXyJFQ5KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5yMjFOwG0> NH;2OlAyQTVyN{i2NS=>
HepG2 cells MXXGeY5kfGmxbjDhd5NigQ>? MlnKRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGg[ZhxemW|c3XkJIlvKEincFeyJINmdGy|IHL5JGdCVDRidILhcpNi[3SrdnH0bY9vKGG|c3H5MEBGSzVyPUCuNlI{KM7:TR?= M3rVblE5Ozl2OUC3
CV1 cells MX7GeY5kfGmxbjDhd5NigQ>? NIfRToJC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKpYX3tZUBtcWejbnSgZolv\GmwZzDkc41icW5iZYjwdoV{e2WmIHnuJIFnemmlYX6g[5Jm\W5ibX;ub4V6KEOYMTDj[YxteyClbz30doFve2[nY4Tl[EB4cXSqIH\1d4VlKEejbEStSGJFKGK7IITyZY5{[WO2aY\heIlwdiCjc4PhfUwhTUN3ME2wMlA{OyEQvF2= M3jCSVE5QDJ4MkC1
CV1 cells M{\yXWZ2dmO2aX;uJIF{e2G7 MXnB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGDQRXJidHCqYTDsbYdidmRiYnnu[Ilv\yCmb33hbY4h\XiycnXzd4VlKGmwIHHmdolk[W5iZ4Ll[Y4hdW:wa3X5JGNXOSClZXzsd{Bkdy22cnHud4Zm[3SnZDD3bZRpKG[3c3XkJGdidDRvRFLEJIJ6KHS{YX7zZYN1cX[jdHnvckBie3OjeTygSWM2OD1|LkS2JO69VQ>? NIjITVgyQDh{NkKwOS=>
U2OS cells MYLGeY5kfGmxbjDhd5NigQ>? M3vGUGFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gVHBCWmejbX3hJIlvKFV{T2OgZ4VtdHNiYomgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwQVAvODJizszN NYfFelFQOTh|Mkm3OVE>
Hep G2 cells NXrjW5pVTnWwY4Tpc44h[XO|YYm= NVvzOZRSSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBRWEGUZ3HtcYEhdGmpYX7kJIJqdmSrbneg[I9u[WmwIHX4dJJme3OnZDDpckBpfW2jbjDI[ZAhTzJiY3XscJMh[29vdILhcpNn\WO2ZXSge4l1cCCJYXy0MWRDTCCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NE4xPCEQvF2= Ml\NNVkxPTN5N{[=
HeLa cells Mn\nSpVv[3Srb36gZZN{[Xl? M1fsOWFod26rc4SgZYN1cX[rdImgZZQhWFCDUnfhcY1iKGyrZ3Hu[EBjcW6maX7nJIRwdWGrbjDlfJBz\XO|ZXSgbY4hcHWvYX6gTIVN[SClZXzsd{Bkdy22cnHud4Zm[3SnZDD3bZRpKEejbEStSGJFKGG|c3Xzd4VlKGG|IITyZY5{[3KrcITpc45idCCjY4TpeoF1cW:wIHL5JGdidDRicnXzdI9ve2ViZXzlcYVvfC2mcnn2[Y4hdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTBwMEG1JO69VQ>? NVvQR|dVOTl{N{W5OlM>
COS1 cells M2fUUmZ2dmO2aX;uJIF{e2G7 M4DWNWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gVHBCWmejbX3hJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCjZoLpZ4FvKGe{ZXXuJI1wdmuneTDDU3MyKGOnbHzzJINwNXS{YX7z[oVkfGWmIIfpeIgh\nW|ZXSgfYVie3RiR3HsOE1FSkRiYomgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwQVAvODJizszN NWr1R3lPOTl3M{C2PFE>
U2OS cells MofqSpVv[3Srb36gZZN{[Xl? NGfTV2tC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKpYX3tZUBmgHC{ZYPz[YQhcW5iVULPV{Bk\WyuczDifUBtfWOrZnXyZZNmKHS{YX7zZYN1cX[jdHnvckBie3OjeTygSWM2OD1yLkC1JO69VQ>? MVyxPVU4PDB3Nh?=
HepG2 cells MkHHSpVv[3Srb36gZZN{[Xl? M{\pWGFod26rc4SgZYN1cX[rdImgZZQhT0GOND30ZYdo\WRiaIXtZY4hWFCDUnfhcY1iKGyrZ3Hu[EBjcW6maX7nJIRwdWGrbjDlfJBz\XO|ZXSgbY4hcHWvYX6gTIVxTzJiY3XscJMh[XO|ZYPz[YQh[XNicnXj[ZB1d3JidILhcpNi[3SrdnH0bY9vKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2wMlA{QSEQvF2= NWfXe256OTl5N{WxOlk>
HepG2 cells NIO1Wm1HfW6ldHnvckBie3OjeR?= MWHB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGDQRXJo[W2vYTDlfJBz\XO|ZXSgbY4hUGWyR{KgZ4VtdHNiYomgS2FNPCC2cnHud4FkfGm4YYTpc44h[XO|YYmsJGVEPTB;MD6yNlMh|ryP MlTjNVk4QDN2NES=
COS7 cells NYjkZoVPTnWwY4Tpc44h[XO|YYm= MnzCRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDy[YNwdWKrbnHueEBRWEGUZ3HtcYEzKEyERDDlfJBz\XO|ZXSgbY4h[W[{aXPhckBoemWnbjDtc45s\XliQ1;TO{Bk\WyuczDjc4V5eHKnc4PpcochT0GONDDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwQVAvOSEQvF2= Mn:xNlAyOzh5NkK=
COS7 cells NYXIN2Y6TnWwY4Tpc44h[XO|YYm= MYXB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIILlZ49u[mmwYX70JHBRSVKpYX3tZVEhVEKGIHX4dJJme3OnZDDpckBi\nKrY3HuJIdz\WWwIH3vcotmgSCFT2O3JINmdGy|IHPv[ZhxemW|c3nu[{BISUx2IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTD0doFve2GldHn2ZZRqd25iYYPzZZktKEWFNUC9NE4xOyEQvF2= M3K2NFIxOTN6N{[y
HEK cells NVP6SlB3TnWwY4Tpc44h[XO|YYm= NIDqdJlC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJGdCVDRvdHHn[4VlKFCSQWLhcJBp[SClaHnt[ZJq[yC{ZXPldJRweiCneIDy[ZN{\WRiaX6gTGVMKGOnbHzzJIJ6KHS{YX7zZYN1cX[jdHnvckBie3OjeTygSWM2OD1zMD61PEDPxE1? MUmyNFI6QTJzNB?=
HEK cells NW\PNZo3TnWwY4Tpc44h[XO|YYm= NV;vb3d4SWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBISUx2LYTh[4dm\CCSUFHS[4FudWFiY3jpcYVzcWNicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGhGUyClZXzsd{BjgSC2cnHud4FkfGm4YYTpc44h[XO|YYmsJGVEPTB;MD6wN|Uh|ryP MlfaNlAzQTl{MUS=
3T3L1 cells NHTGTJdHfW6ldHnvckBie3OjeR?= M2\XR|ch\GG7cx?= Mlu1TY5lfWO2aX;uJI9nKGGmaYDv[4Vv\XOrczDpckBud3W|ZTCzWFNNOSClZXzsd{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDsbZBq\CCjY3P1cZVt[XSrb36gZYZ1\XJiNzDkZZl{KGK7IF;pcEBz\WRiTzDzeIFqdmmwZx?= MmLJNlA2Ojd7Nkm=
CHO-K1 cells M2nmXGZ2dmO2aX;uJIF{e2G7 MlTIVIFzfGmjbDDh[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGDQRXJo[W2vYT3MRmQh\XiycnXzd4VlKGmwIFPIU{1MOSClZXzsd{Bkdy22cnHud4Zm[3SnZDD3bZRpKEeDTESgZZN{\XO|ZXSgZZMhdHWlaX\ldoF{\SCjY4Tpeol1gSCkeTD0doFve2GldHn2ZZRqd25iYYPzZZktKEWFNUC9NE4yKM7:TR?= MYOyNFUzPzl4OR?=
HEK293T cells M{PlcGZ2dmO2aX;uJIF{e2G7 NXrTcHV7OSEQvF2= M{TMUlI1KGi{cx?= M1jmeXBienSrYXygZYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGtUGJFKGW6cILld5Nm\CCrbjDISWszQTOWIHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBz\WOncITvdkB1emGwc3HjeIl3[XSrb36gZZQhOSC3TTDh[pRmeiB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5 M4LpbFIyODNyMk[z
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HEK293 cells MV;GeY5kfGmxbjDhd5NigQ>? MXmxOkB1dyB{MDDodpM> NEjWR5BVemGwc3HjeIl3[XSrb36gc4YhT2GuND3meZNm\CCqdX3hckBRWEGUZ3HtcYEh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{Bi\nSncjCxOkB1dyB{MDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUCuNFQ{KM7:TR?= NHrISmszOTF{OE[wNC=>
HepG2 cells NVr1T5NuTnWwY4Tpc44h[XO|YYm= NXLDO3hSOTBidX3vcE9N NG\vNI0zPCCqcoO= NYDVTG1QUW6lcnXhd4UhcW5iZ3z1Z49{\SClb37zeY1xfGmxbjDpckBpfW2jbjDI[ZBIOiClZXzsd{BifCBzMDD1cY9tN0xiYX\0[ZIhOjRiaILzJJJmdGG2aY\lJJRwKGOxboTyc4w> MViyNVI2Pjd2OB?=
3T3L1 cell NVHNcWh{TnWwY4Tpc44h[XO|YYm= Ml6wNUB2VQ>? MX;JcoR2[3Srb36gc4YhdW:3c3WgN3Q{VDFiY3XscEBlcW[oZYLlcpRq[XSrb36gZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iYXPjeY12dGG2aX;uJI9nKGmwdILhZ4VtdHWuYYKgcIlxcWRiZILvdIxmfCCjdDCxJJVOKGK7IF;pcEBz\WRiTzDzeIFqdmmwZx?= NGjZdGwzOTRyMUGxPC=>
CV1 cells M4HDOmZ2dmO2aX;uJIF{e2G7 MmP5OFAhcA>? MWPB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGDQRXJo[W2vYT3MRmQh\XiycnXzd4VlKGmwIFPWNUBk\WyuczDjc{11emGwc3\lZ5Rm\CC5aYToJGdidDRiYX\0[ZIhPDBiaILzJIJ6KGy3Y3nm[ZJie2ViYnHz[YQhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMTFOwG0> NF3uWXQzOTVzNUC2Ny=>
HepG2 cells MVjGeY5kfGmxbjDhd5NigQ>? M17ESWFod26rc4SgZYN1cX[rdImgZZQhWFCDUnfhcY1iKHKnY3XweI9zKGW6cILld5Nm\CCrbjDoeY1idiCKZYDHNkBk\WyuczDifUBRWFKHLXz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2wMlAyKM7:TR?= NHTmT4szOTR6MkS0Oi=>
HepG2 cells MVTGeY5kfGmxbjDhd5NigQ>? NVvTc3ZMXHKjboPhZ5RqfmG2aX;uJI9nKGi3bXHuJHBRSVKpYX3tZUBmgHC{ZYPz[YQhcW5iaIXtZY4hUGWyR{KgZ4VtdHNiY3:teJJidnOoZXP0[YQhf2m2aDDQVHJGOy2WSz3MeYMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUCuNFUh|ryP NV2zcotROjF2NUC0Olg>
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COS1 cells NGDXXWFHfW6ldHnvckBie3OjeR?= M2LSTVI1KGi{cx?= NEDVSZVVemGwc3HjeIl3[XSrb36gc4YhcHWvYX6g[pVtdCCuZX7neIghWFCDUnfhcY1iKGW6cILld5Nm\CCrbjDDU3MyKGOnbHzzJINwNXS{YX7z[oVkfGWmIIfpeIghWliUYXzwbIEh[W[2ZYKgNlQhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjF{IN88US=> MXyyNlE6PzN7Nh?=
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293H DA cells MnrDSpVv[3Srb36gZZN{[Xl? MVexOkBp NYX0cnFxSWexbnnzeEBi[3Srdnn0fUBifCCSUFHS[4FudWFiTFLEJIlvKGi3bXHuJFI6O0hiRFGgZ4VtdHNiYX\0[ZIhOTZiaILzJIJ6KFSULV\SSXQh[WO2aY\heIlwdiC{ZYDvdpRmeiCjc4PhfUwhTUN3ME2wMlAxOjRizszN MmrLNlI2QDJ7N{O=
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HepG2 cells MlX3SpVv[3Srb36gZZN{[Xl? NYLRdZQ1OTBidV2= NVf2O2dlOjRiaB?= NVvxc4VmWmWmdXP0bY9vKG:oIHfseYNwe2ViY3;ud5VueHSrb36gbY4hcW6|dXzpck1z\XOrc4ThcpQhcHWvYX6gTIVxTzJiY3XscJMh[XRiMUCgeW0h[W[2ZYKgNlQhcHK|IHL5JIdtfWOxc3Wgc5hq\GG|ZTDt[ZRpd2RiaX6gdJJme2WwY3Wgc4YhOC5zIIXNJI9nKGmwc4XsbY4> M{K0RlI{ODJ3MkS0
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Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 176.17
Formula

C10H8O3

CAS No. 90-33-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC(=O)OC2=C1C=CC(=C2)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05295680 Not yet recruiting Drug: Hymecromone Primary Sclerosing Cholangitis Paul Bollyky|Stanford University May 2022 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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