Home Apoptosis Bcl-2 inhibitor Zeaxanthin

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Zeaxanthin Bcl-2 inhibitor

Cat.No.S3243

Zeaxanthin, the carotenoid alcohol participates in the xanthophyll cycle, activates the extrinsic apoptosis pathway which induces apoptosis on uveal melanoma cells with IC50 value 40.8 µM.
Zeaxanthin Bcl-2 inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 568.87

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Quality Control

Batch: S324301 CHCl3]4 mg/mL]false]DMSO]Insoluble]false]Water]Insoluble]false Purity: 98.04%
98.04

Solubility

In vitro
Batch:

CHCl3 : 4 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 568.87 Formula

C40H56O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 144-68-3 -- Storage of Stock Solutions

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC50/Ki
Bcl-2
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-06-05)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05232409 RECRUITING
Cancer Metastatic; Metastatic Solid Tumor
Valley Health System
 2022-04-17 PHASE1
NCT06965426 RECRUITING
Macular Degenerative Disease
Insight Eyecare Specialties, Inc. dba Vision Source Eyecare,
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NCT06489873 RECRUITING
Cognitive Performance; Age-Related Macular Degeneration; Bone Loss
Texas A&M University
 2024-02-07
NCT06237127 Recruiting
Age-Related Macular Degeneration
University of California Davis|United States Department of Agriculture (USDA)
 2024-04-29 Not Applicable
NCT07355725 COMPLETED
Cognitive
Bioagile Therapeutics Pvt. Ltd.
 2022-07-21
NCT05283941 Recruiting
Macular Degeneration|Retinal Degeneration|Retinal Diseases|Eye Diseases
Tufts University|American Pistachio Growers
 2022-06-10 Not Applicable

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