Home Immunology & Inflammation ROS inhibitor Pyrroloquinoline quinone

research use only

Pyrroloquinoline quinone ROS inhibitor

Cat.No.S3578

Pyrroloquinoline quinone (PQQ, Methoxatin) is a natural anti-oxidant with anti-oxidative and anti-aging effects. This compound prevents estrogen deficiency-induced osteoporosis. It can alleviate allergic airway inflammation in mice by improving the immune microenvironment and regulating the JAK-STAT signaling pathway. This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
Pyrroloquinoline quinone ROS inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 330.21

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S357801 DMSO]Insoluble]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.88%
99.88

Chemical Information, Storage & Stability

Molecular Weight 330.21 Formula

C14H6N2O8

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 72909-34-3 -- Storage of Stock Solutions

Solubility

In vitro
Batch:

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro

The activation of AMPK by this compound is required for the regulation of mitochondrial biogenesis in rotenone-injured SH-SY5Y cells, the upregulation of PGC-1α induced by this chemical is reduced by inhibition of AMPK.[2]
In vivo

Pyrroloquinoline quinone dose-dependently alleviates the locomotor deficits and nigral dopaminergic neuron loss in PD mice, significantly diminishes the reduction of mitochondria number and their pathological change in the midbrain, also dose-dependently blocks rotenone-caused reduction in the expression of PGC-1α and TFAM, two key activators of mitochondrial gene transcription, in the midbrain.[2]
References

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.