N-Methylnicotinamide

Catalog No.S3321 Synonyms: MNA, Nicotinyl Methylamide, N-Methyl-3-pyridinecarboxamide

For research use only.

N-Methylnicotinamide (MNA, Nicotinyl Methylamide, N-Methyl-3-pyridinecarboxamide) is an active endogenous metabolite that improves endothelial dysfunction and attenuates atherogenesis via the modulation of ADMA-DDAH axis.

N-Methylnicotinamide Chemical Structure

CAS No. 114-33-0

Purity & Quality Control

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Biological Activity

Description

N-Methylnicotinamide (MNA, Nicotinyl Methylamide, N-Methyl-3-pyridinecarboxamide) is an active endogenous metabolite that improves endothelial dysfunction and attenuates atherogenesis via the modulation of ADMA-DDAH axis.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 27 mg/mL
(198.31 mM)
Water 27 mg/mL
(198.31 mM)
Ethanol '''''27 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 136.15
Formula

C7H8N2O

CAS No. 114-33-0
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04746664 Not yet recruiting Behavioral: Nutritional counselling Malnutrition|Quality of Life Bahir Dar University September 2021 Not Applicable
NCT05021952 Recruiting Device: mHealth App and wearable device Prostate Cancer Seoul St. Mary''s Hospital|National IT Industry Promotion Agency May 21 2021 Not Applicable
NCT04907591 Recruiting Device: mHealth App and wearable device Gastric Cancer Samsung Medical Center|National IT Industry Promotion Agency May 17 2021 Not Applicable
NCT04985877 Recruiting Dietary Supplement: Yakult light 300 Sarcopenia|Inflammation|Aging Taipei Medical University|Yakult Honsha Co. LTD March 23 2021 Not Applicable
NCT04516057 Recruiting Drug: Nabilone|Other: Placebo Alzheimer Disease|Agitation Sunnybrook Health Sciences Centre|Alzheimer''s Drug Discovery Foundation|Weston Brain Institute February 1 2021 Phase 3

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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