Sakuranetin

Catalog No.S0938

For research use only.

Sakuranetin belongs to the group of methoxylated flavanones, with a widely bioactivity of antiproliferative against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320), antiviral activity towards human rhinovirus 3 and influenza B virus, antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties.

Sakuranetin Chemical Structure

CAS No. 2957-21-3

Purity & Quality Control

Choose Selective Fungal Inhibitors

Biological Activity

Description Sakuranetin belongs to the group of methoxylated flavanones, with a widely bioactivity of antiproliferative against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320), antiviral activity towards human rhinovirus 3 and influenza B virus, antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties.
In vitro

Sakuranetin can significantly inhibit NO induction and inducible nitric oxide synthase (iNOS) expression, also decrease the expression of type 1 IL-1 receptor gene and phosphorylation of Akt.[2]

In vivo

sakuranetin prevents and reduces pulmonary inflammation induced by LPS through modulating oxidative stress, the NF-κB pathway, and lung function.[3]

Protocol (from reference)

Cell Research:

[2]

  • Cell lines: IL-1β-treated rat hepatocytes
  • Concentrations: 20, 40, 60 μM
  • Incubation Time: 8 h
  • Method:

    Hepatocytes are treated with 1 nM IL-1β in the absence or presence of sakuranetin for 8 h. The NO levels are then measured in the medium.

Animal Research:

[3]

  • Animal Models: mice of lipopolysaccharide (LPS)-induced acute lung injury (ALI)
  • Dosages: 20 mg·kg−1·animal−1
  • Administration: i.t.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 286.28
Formula

C16H14O5

CAS No. 2957-21-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=CC(=C2C(=O)CC(OC2=C1)C3=CC=C(C=C3)O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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