Home Microbiology Fungal inhibitor Sakuranetin For research use only.

Sakuranetin

Sakuranetin belongs to the group of methoxylated flavanones, with a widely bioactivity of antiproliferative against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320), antiviral activity towards human rhinovirus 3 and influenza B virus, antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties.

Sakuranetin Chemical Structure

Sakuranetin Chemical Structure

CAS: 2957-21-3

Purity & Quality Control

Batch: S093801 DMSO] 57 mg/mL] false] ] ] false] ] ] false Purity: 99.99%
99.99

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Biological Activity

Description Sakuranetin belongs to the group of methoxylated flavanones, with a widely bioactivity of antiproliferative against human cell lines typical for B16BL6 melanoma, esophageal squamous cell carcinoma (ESCC) and colon cancer (Colo 320), antiviral activity towards human rhinovirus 3 and influenza B virus, antioxidant, antimicrobial, antiinflammatory, antiparasitic, antimutagenic, and antiallergic properties.
In vitro
In vitro

Sakuranetin can significantly inhibit NO induction and inducible nitric oxide synthase (iNOS) expression, also decrease the expression of type 1 IL-1 receptor gene and phosphorylation of Akt.[2]
Cell Research Cell lines IL-1β-treated rat hepatocytes
Concentrations 20, 40, 60 μM
Incubation Time 8 h
Method

Hepatocytes are treated with 1 nM IL-1β in the absence or presence of sakuranetin for 8 h. The NO levels are then measured in the medium.
In Vivo
In vivo

sakuranetin prevents and reduces pulmonary inflammation induced by LPS through modulating oxidative stress, the NF-κB pathway, and lung function.[3]
Animal Research Animal Models mice of lipopolysaccharide (LPS)-induced acute lung injury (ALI)
Dosages 20 mg·kg−1·animal−1
Administration i.t.

Chemical Information & Solubility

Molecular Weight 286.28 Formula

C16H14O5
CAS No. 2957-21-3 SDF --
Smiles COC1=CC(=C2C(=O)CC(OC2=C1)C3=CC=C(C=C3)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 57 mg/mL ( (199.1 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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