L-Cystine

Name: L-Cystine
Brand: Selleck Chemicals
SKU: S4808
Rating: 5 (1 reviews)

Catalog No.S4808 Purity: 98%

L-Cystine is the oxidized dimer form of the amino acid L-cysteine which is a non-essential amino acid of the human body. It is required for wound healing and formation of epithelial tissue.

L-Cystine Chemical Structure

CAS: 56-89-3

Purity & Quality Control

Batch: S480801 0.5MNAOH] 6.02 mg/mL] false] DMSO] 0.001 mg/mL] false] Water] Insoluble] false Purity: 98%

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Biological Activity

Description	L-Cystine is the oxidized dimer form of the amino acid L-cysteine which is a non-essential amino acid of the human body. It is required for wound healing and formation of epithelial tissue.

In vitro
In vitro	L-cysteine can enhance proliferation and differentiation of NSCs via the CBS/H2S pathway^[1].
Cell Research	Cell lines	Neural stem cells (NSCs)
	Concentrations	0.1, 0.5, 1, 5, 10 and 50 μM
	Incubation Time	24 and 48 h
	Method	NSCs are seeded at 96-well plates and then treated with the indicated concentrations of L-cysteine (L-cys) for 24 and 48 h in reduced growth medium. NSCs proliferation is measured by MTT analysis.

In Vivo
In vivo	L-Cysteine dose-dependently decreases food intake in both rats and mice following oral gavage and intraperitoneal administration. L-Cysteine increases neuronal activation in the area postrema and delayed gastric emptying. It suppresses plasma acyl ghrelin levels and does not reduce food intake in transgenic ghrelin-overexpressing mice. Repeated L-cysteine administration decreases food intake in rats and obese mice. L-Cysteine reduces hunger and plasma acyl ghrelin levels in humans^[2].
Animal Research	Animal Models	Male C57BL/6 mice
	Dosages	2 mmol/kg
	Administration	i.p.

References

Chemical Information & Solubility

Molecular Weight	240.30	Formula	C₆H₁₂N₂O₄S₂
CAS No.	56-89-3	SDF	--
Smiles	C(C(C(=O)O)N)SSCC(C(=O)O)N
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

0.5MNAOH : 6.02 mg/mL

DMSO : 0.001 mg/mL ( (0.0 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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