L-Cystine

Catalog No.S4808

For research use only.

L-Cystine is the oxidized dimer form of the amino acid L-cysteine which is a non-essential amino acid of the human body. It is required for wound healing and formation of epithelial tissue.

L-Cystine Chemical Structure

CAS No. 56-89-3

Purity & Quality Control

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Biological Activity

Description L-Cystine is the oxidized dimer form of the amino acid L-cysteine which is a non-essential amino acid of the human body. It is required for wound healing and formation of epithelial tissue.
In vitro

L-cysteine can enhance proliferation and differentiation of NSCs via the CBS/H2S pathway[1].

In vivo L-Cysteine dose-dependently decreases food intake in both rats and mice following oral gavage and intraperitoneal administration. L-Cysteine increases neuronal activation in the area postrema and delayed gastric emptying. It suppresses plasma acyl ghrelin levels and does not reduce food intake in transgenic ghrelin-overexpressing mice. Repeated L-cysteine administration decreases food intake in rats and obese mice. L-Cysteine reduces hunger and plasma acyl ghrelin levels in humans[2].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: Neural stem cells (NSCs)
  • Concentrations: 0.1, 0.5, 1, 5, 10 and 50 μM
  • Incubation Time: 24 and 48 h
  • Method: NSCs are seeded at 96-well plates and then treated with the indicated concentrations of L-cysteine (L-cys) for 24 and 48 h in reduced growth medium. NSCs proliferation is measured by MTT analysis.
  • (Only for Reference)
Animal Research:[1]
  • Animal Models: Male C57BL/6 mice
  • Dosages: 2 mmol/kg
  • Administration: i.p.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 0.001 mg/mL
(0.0 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 240.30
Formula

C6H12N2O4S2

CAS No. 56-89-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(C(C(=O)O)N)SSCC(C(=O)O)N

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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