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S-(-)-Cotinine

Name: S-(-)-Cotinine
Brand: Selleck Chemicals
SKU: S9339
Rating: 5 (1 reviews)

Catalog No.S9339 Purity: 99.86%

S-(-)-Cotinine, a constituent of tobacco products and the major metabolite of nicotine, stimulates nicotinic receptors to evoke the release of DA in a calcium-dependent manner from superfused rat striatal slices.,

S-(-)-Cotinine Chemical Structure

CAS: 486-56-6

Purity & Quality Control

Batch: S933901 Purity: 99.86%

99.86

S-(-)-Cotinine Related Products

Biological Activity

Description	S-(-)-Cotinine, a constituent of tobacco products and the major metabolite of nicotine, stimulates nicotinic receptors to evoke the release of DA in a calcium-dependent manner from superfused rat striatal slices.,

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05836103	Not yet recruiting	Tobacco Cigarette Smoking	Johns Hopkins Bloomberg School of Public Health	May 1 2024	Not Applicable
NCT06111755	Not yet recruiting	Smoking Cessation	Yale University\|American Lung Association	November 2023	Not Applicable

Chemical Information & Solubility

Molecular Weight	176.22	Formula	C₁₀H₁₂N₂O
CAS No.	486-56-6	SDF	--
Density	1.110 g/mL
Smiles	CN1C(CCC1=O)C2=CN=CC=C2
Storage (From the date of receipt)	2 years -20°C(in the dark) liquid	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	2 years -20°C(in the dark) liquid		1 month-20°Cin solvent

In vitro
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In vivo
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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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