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Scopolamine AChR antagonist

Name: Scopolamine
Brand: Selleck Chemicals
SKU: S9326
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S9326

Scopolamine (Skopolamin) is a tropane alkaloid derived from plants of the nightshade family, specifically Hyoscyamus niger and Atropa belladonna, with anticholinergic, antiemetic and antivertigo properties.

Chemical Structure

Molecular Weight: 303.35

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Quality Control

Batch: Purity: 99.79%

99.79

Related Targets	Adrenergic Receptor 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other AChR Inhibitors	PNU-120596 Benzethonium Chloride Arecoline HBr Otilonium Bromide Palmatine Lycorine Nitenpyram PNU 282987 HCl Chelidonine Hyoscyamine

Solubility

In vitro
Batch:

DMSO : 61 mg/mL (201.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 61 mg/mL

Ethanol : 61 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.150mg/ml (0.49mM)	Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.150mg/ml (0.49mM)	Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	303.35	Formula	C₁₇H₂₁NO₄	Storage (From the date of receipt)	2 years -20°C liquid
CAS No.	51-34-3	--		Storage (From the date of receipt)	2 years -20°C liquid

Read more about storage stability stock solution CAS number

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-06-05)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04366518	RECRUITING	Hallucinations, Auditory; Psychosis	Yale University	2021-07-15	EARLY_PHASE1
NCT07423923	ENROLLING_BY_INVITATION	Scopolamine or Placebo; Schema to Organize Memory or no Schema	University of Arizona	2025-04-01	EARLY_PHASE1
NCT05594017	RECRUITING	Epilepsy; Seizures; Cognitive Impairment, Mild; Memory Disorders; Memory Loss	University of Texas Southwestern Medical Center	2019-08-01	EARLY_PHASE1
NCT05852730	RECRUITING	Motion Sickness, Space; Motion Simulation; Parabolic Flight	Repurposed Therapeutics, Inc.	2021-08-10	PHASE2
NCT04240626	ACTIVE_NOT_RECRUITING	Obesity, Morbid; Surgery; Bariatric Surgery Candidate	University of California, Davis	2021-01-20	PHASE4
NCT03616067	TERMINATED	Cerebral Palsy	Hospices Civils de Lyon	2022-04-27	PHASE3

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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