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Benzoylaconitine

Name: Benzoylaconitine
Brand: Selleck Chemicals
SKU: S0944
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S0944

Benzoylaconine (Isaconitine, Pikraconitin) is an alkaloid derived from the Chinese traditional medicine Radix Aconiti Lateralis Preparata (Fuzi). Benzoylaconitine inhibits production of IL-6 and IL-8 via MAPK, Akt, NF-κB signaling in IL-1β-induced human synovial cells.

Chemical Structure

Molecular Weight: 603.70

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S094401 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.92%

99.92

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Chemical Information, Storage & Stability

Molecular Weight	603.70	Formula	C₃₂H₄₅NO₁₀	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	466-24-0	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Isaconitine, Pikraconitin			Smiles	CCN1CC2(C(CC(C34C2C(C(C31)C5(C6C4CC(C6OC(=O)C7=CC=CC=C7)(C(C5O)OC)O)O)OC)OC)O)COC

Solubility

In vitro
Batch:

DMSO : 100 mg/mL ( (165.64 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	Benzoylaconitine is a lower toxic monoester type alkaloid considered as the pharmacodynamic constituent in Aconitum species, which exerts an anti-inflammatory effect dependent on MAPK, Akt and nuclear factor-κB (NF-κB) pathways in human synovial cells stimulated with IL-1β.^[1]
In vivo	Benzoylaconitine shows efficient in vivo anti-inflammatory effect with high ear (69.8 %) and paw (87.1 %) swelling suppressing rate.^[3]
References	https://pubmed.ncbi.nlm.nih.gov/31735734/ https://pubmed.ncbi.nlm.nih.gov/31735734/ https://pubmed.ncbi.nlm.nih.gov/32252000/

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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