Benzoylaconitine

Name: Benzoylaconitine
Brand: Selleck Chemicals
SKU: S0944
Rating: 5 (1 reviews)

Synonyms: Isaconitine, Pikraconitin

Catalog No.S0944 Purity: 99.92%

Benzoylaconine (Isaconitine, Pikraconitin) is an alkaloid derived from the Chinese traditional medicine Radix Aconiti Lateralis Preparata (Fuzi). Benzoylaconitine inhibits production of IL-6 and IL-8 via MAPK, Akt, NF-κB signaling in IL-1β-induced human synovial cells.

Benzoylaconitine Chemical Structure

CAS: 466-24-0

Purity & Quality Control

Batch: S094401 DMSO] 100 mg/mL] false] ] ] false] ] ] false Purity: 99.92%

99.92

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Biological Activity

Description	Benzoylaconine (Isaconitine, Pikraconitin) is an alkaloid derived from the Chinese traditional medicine Radix Aconiti Lateralis Preparata (Fuzi). Benzoylaconitine inhibits production of IL-6 and IL-8 via MAPK, Akt, NF-κB signaling in IL-1β-induced human synovial cells.

In vitro
In vitro	Benzoylaconitine is a lower toxic monoester type alkaloid considered as the pharmacodynamic constituent in Aconitum species, which exerts an anti-inflammatory effect dependent on MAPK, Akt and nuclear factor-κB (NF-κB) pathways in human synovial cells stimulated with IL-1β.^[1]
Cell Research	Cell lines	IL-1β-stimulated human synovial SW982 cells
	Concentrations	5, 10 µM
	Incubation Time	30 min
	Method	The SW982 cells are pretreated with various doses (0, 5 and 10 μM) of BAC for 30 min, followed by IL-1β stimulation (10 ng/mL) for 12 h. The levels of IL-6 and IL-8 in supernatants of cell cultures are determined by ELISA kits according to the manufacturer's recommendations.

In Vivo
In vivo	Benzoylaconitine shows efficient in vivo anti-inflammatory effect with high ear (69.8 %) and paw (87.1 %) swelling suppressing rate.^[3]

References

Chemical Information & Solubility

Molecular Weight	603.70	Formula	C₃₂H₄₅NO₁₀
CAS No.	466-24-0	SDF	--
Smiles	CCN1CC2(C(CC(C34C2C(C(C31)C5(C6C4CC(C6OC(=O)C7=CC=CC=C7)(C(C5O)OC)O)O)OC)OC)O)COC
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (165.64 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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