Home Apoptosis Apoptosis related chemical Sophoridine

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Sophoridine Apoptosis related chemical

Cat.No.S3895

Sophoridine (5-Epidihydrosophocarpine, Dihydro-5-episophocarpine), a natural product obtained from medicinal plants, has a variety of pharmacological effects, including anti-cancer and anti-arrhythmia, and affects the immune and central nervous systems.
Sophoridine Apoptosis related chemical Chemical Structure

Chemical Structure

Molecular Weight: 248.36

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S389501 DMSO]49 mg/mL]false]]]false]]]false Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 248.36 Formula

C15H24N2O

 Storage (From the date of receipt)
CAS No. 6882-68-4 -- Storage of Stock Solutions

Synonyms 5-Epidihydrosophocarpine, Dihydro-5-episophocarpine Smiles C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1

Solubility

In vitro
Batch:

DMSO : 49 mg/mL (197.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro
Sophoridine kills cancer cells but has low cytotoxicity to normal cells. Pancreatic cancer cells are particularly sensitive. This compound inhibits the proliferation of pancreatic cancer cells and induces cell cycle arrest at S phase and mitochondrial-related apoptosis. Moreover, it induces a sustained activation of the phosphorylation of ERK and JNK. In addition, this chemical provokes the generation of reactive oxygen species (ROS) in pancreatic cancer cells[1]. It also triggers significant down-regulated the expression of p27, CDK2, Survivin, Livin, Bcl-2, E2F1 and the transcriptional activity of FoxM1, NF-κb and AP-1, meanwhile, up-regulated the expression of caspase-3/8, p53, Smac, c-JNK and p38-MAPK. This compound significantly inhibits ubiquitin-proteasome in tumor cells[2].
In vivo
Sophoridine is an effective agent that can inhibit the growth of xenograft pancreatic tumors in vivo with well-tolerated toxicity[1]. This compound attenuates intestinal inflammation in the experimental colitis model, which is associated with the downregulation of ICAM-1 gene expression[3].
References

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