Silymarin

For research use only. Not for use in humans.

Catalog No.S2358 Synonyms: Silybin B

2 publications

Silymarin Chemical Structure

Molecular Weight(MW): 482.44

Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.

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Selleck's Silymarin has been cited by 2 publications

1 Customer Review

  • Silymarin improved HFD-induced hepatic injury. Mice were fed with NCD or HFD for 14 weeks, then treated with silymarin for 3 weeks, followed by 12 h fasting. (a) ALT and AST levels in serum were determined. (b) Hematoxylin and eosin staining of liver (400×) was showed. Values are means ± SD (n = 8). *p < 0.05 and **p < 0.01 compared to HFD group.

    Pharm Biol, 2016, 8:1-6.. Silymarin purchased from Selleck.

Purity & Quality Control

Biological Activity

Description Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.
In vitro

Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer. [1] The mechanisms of action of silymarin involve different biochemical events, such as the stimulation of the synthetic rate of ribosomal RNA (rRNA) species through stimulation of polymerase I and rRNA transcription, protecting the cell membrane from radical-induced damage and blockage of the uptake of toxins such as alpha-amanitin. [2] Silymarin can also provide substantial protection against different stages of UVB-induced carcinogenesis, possibly via its strong antioxidant properties. sup>[3]

In vivo LD50: Mice 391.4mg/kg (i.v.); Rats 370.1mg/kg (i.v.); Rabbits 142.3mg/kg (i.v.) sup>[4]

Protocol

Solubility (25°C)

In vitro DMSO 96 mg/mL warmed (198.98 mM)
Ethanol 1 mg/mL (2.07 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 482.44
Formula

C25H22O10

CAS No. 65666-07-1
Storage powder
in solvent
Synonyms Silybin B
Smiles COC1=CC(=CC=C1O)C2OC3=CC=C(C=C3OC2CO)C4OC5=C(C(=CC(=C5)O)O)C(=O)C4O

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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