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Silymarin Antioxidant chemical

Cat.No.S2358

Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer.
Silymarin Antioxidant chemical Chemical Structure

Chemical Structure

Molecular Weight: 482.44

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  • Silymarin UV 80%
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Chemical Information, Storage & Stability

Molecular Weight 482.44 Formula

C25H22O10

 Storage (From the date of receipt) 3 years -20°C powder (seal)
CAS No. 65666-07-1 Download SDF Storage of Stock Solutions

Synonyms Silybin B Smiles COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O

Mechanism of Action

In vitro

Silymarin (Silybin B), a polyphenolic flavonoid extracted from the seeds of Silybum marianum or milk thistle, is used in the prevention and treatment of liver diseases and primary liver cancer. The mechanisms of action of this compound involve different biochemical events, such as the stimulation of the synthetic rate of ribosomal RNA (rRNA) species through stimulation of polymerase I and rRNA transcription, protecting the cell membrane from radical-induced damage and blockage of the uptake of toxins such as alpha-amanitin. This chemical can also provide substantial protection against different stages of UVB-induced carcinogenesis, possibly via its strong antioxidant properties.

In vivo

LD50: Mice 391.4mg/kg (i.v.); Rats 370.1mg/kg (i.v.); Rabbits 142.3mg/kg (i.v.)

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05099601 Unknown status
Melasma
Assiut University
 May 2022 Phase 4
NCT04434404 Completed
Breast Cancer
Horus University
 September 10 2018 Phase 4
NCT03216668 Unknown status
Liver Function Failure
Nhat Nhat Pharmaceutical Company
 June 15 2017 Phase 3
NCT02006498 Completed
Non-alcoholic Fatty Liver Disease
University of Malaya|Rottapharm
 June 2012 Phase 2
NCT01018615 Completed
Chronic Hepatitis C|Oxidative Stress
University of North Carolina Chapel Hill|National Center for Complementary and Integrative Health (NCCIH)|National Institutes of Health (NIH)
 November 2009 Phase 1

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