Home DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor Bis(2-ethylhexyl) phthalate

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Bis(2-ethylhexyl) phthalate DNA/RNA Synthesis inhibitor

Cat.No.S3360

Bis(2-ethylhexyl) phthalate (Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon) induces DNA strand breaks and gene expression alterations in larval zebrafish Danio rerio.

Bis(2-ethylhexyl) phthalate DNA/RNA Synthesis inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 390.56

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Quality Control

Batch: S336001 Purity: 99.87%
99.87

Solubility

In vitro
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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 390.56 Formula

C24H38O4

 Storage (From the date of receipt) 2 years 4°C liquid
CAS No. 117-81-7 -- Storage of Stock Solutions

Synonyms Dioctyl phthalate, DOP, Diplast O, ESBO-D 82, Ergoplast FDO, Ergoplast FDO-S, Etalon Smiles CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC

Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03446807 Withdrawn
Parkinson Disease|Multiple System Atrophy|Progressive Supranuclear Palsy
Loma Linda University|H. Lundbeck A/S
 December 2021 Phase 2
NCT04977388 Recruiting
Menkes Disease|Occipital Horn Syndrome
Stephen G. Kaler MD|Nationwide Children''s Hospital
 July 12 2021 Phase 1|Phase 2
NCT04922203 Enrolling by invitation
in Situ Simulation
Jean François Brichant|University of Liege
 May 28 2021 Not Applicable
NCT04682236 Unknown status
Acute Renal Failure
University Hospital Strasbourg France
 November 25 2020 --

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