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(+)-α-Lipoic acid NF-κB inhibitor

Name: (+)-α-Lipoic acid
Brand: Selleck Chemicals
SKU: S3998
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3998

(+)-α-Lipoic acid ((R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid), a physiological form of thioctic acid, is a strong antioxidant that relieves diabetic neuropathic symptoms. It shows superior antioxidative effects to its racemate. This compound is an essential cofactor of mitochondrial enzyme complexes. This chemical inhibits NF-κB-dependent HIV-1 LTR activation.

Chemical Structure

Molecular Weight: 206.33

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Quality Control

Batch: S399801 DMSO]125 mg/mL]false]]]false]]]false Purity: 99.78%

Cited in Nature Medicine for its top-tier quality
COA
SDS/MSDS
Datasheet

99.78

Related Targets	HDAC Antioxidant ROS IκB/IKK Nrf2 AP-1 MALT NOD
Other NF-κB Inhibitors	DCZ0415 Omaveloxolone (RTA-408) BAY 11-7082 (BAY 11-7821) JSH-23 QNZ (EVP4593) Caffeic Acid Phenethyl Ester SC75741 DHA (Dihydroartemisinin) Andrographolide CBL0137

Solubility

In vitro
Batch:

DMSO : 125 mg/mL (605.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	6.250mg/ml (30.29mM)	Taking the 1 mL working solution as an example, add 50 μL of 125 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	206.33	Formula	C₈H₁₄O₂S₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	1200-22-2	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	(R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid			SMILES	C1CSSC1CCCCC(=O)O

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	NF-κB LTR LTR
In vitro	Using L6 myotubes and 3T3-L1 adipocytes as a model of muscle and fat cells in culture, (+)-α-Lipoic acid (R-LA) is shown to increase tyrosine phosphorylation of insulin receptor and IRS-1, to enhance PI 3-kinase and Akt1 activities, to elevate GLUT4 content in the plasma membranes, and to increase glucose uptake into the cells. 3T3-L1 adipocytes possess a low capacity to reduce this compound and the oxidized isoforms are effective in stimulating glucose transport. This chemical modulates glucose transport by changing intracellular redox status. Insulin receptor is a target of this compound action.
References	[1] https://pubmed.ncbi.nlm.nih.gov/11795898/ [2] https://pubmed.ncbi.nlm.nih.gov/8925935/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-05)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07725484	NOT_YET_RECRUITING	Heart Failure Due to Coronary Artery Disease	Shanghai Zhongshan Hospital	2026-11-01	PHASE3
NCT05713799	NOT_YET_RECRUITING	Insulin Resistance; Obesity	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	2026-09-09	PHASE2
NCT07685431	RECRUITING	Female Infertility Due to Diminished Ovarian Reserve	Kaohsiung Veterans General Hospital.	2026-06-11
NCT06286098	ENROLLING_BY_INVITATION	Hemodialysis Complication; Pediatric Kidney Disease; Cardiovascular Complication	Ain Shams University	2025-02-02	PHASE3
NCT07785544	NOT_YET_RECRUITING	Painful Diabetic Peripheral Neuropathy	Bangladesh Medical University	2026-08-25
NCT07501663	RECRUITING	Peripheral Neuropathy	Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University	2026-01-20

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