Hederagenin

For research use only.

Catalog No.S3899 Synonyms: Caulosapogenin, Hederagenol, Hederagenic acid, Astrantiagenin E

Hederagenin Chemical Structure

CAS No. 465-99-6

Hederagenin (Caulosapogenin, Hederagenol, Hederagenic acid, Astrantiagenin E) is a highly water insoluble triterpenoid compound that can be found in various plants including Hedera helix and Chenopodium quinoa. It exhibits a variety of biological activities, including potent antitumor properties both in vitro and in vivo. Hederagenin inhibits LPS-stimulated expression of iNOS, COX-2, and NF-κB.

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Biological Activity

Description Hederagenin (Caulosapogenin, Hederagenol, Hederagenic acid, Astrantiagenin E) is a highly water insoluble triterpenoid compound that can be found in various plants including Hedera helix and Chenopodium quinoa. It exhibits a variety of biological activities, including potent antitumor properties both in vitro and in vivo. Hederagenin inhibits LPS-stimulated expression of iNOS, COX-2, and NF-κB.
Targets
iNOS [2]
()
COX-2 [2]
()
NF-κB [2]
()
In vitro

Hederagenin could induce apoptosis of LoVo cells through the mitochondrial apoptotic pathway. Hederagenin could induce the up-regulation of Bax and down-regulation of Bcl-2, Bcl-xL and Survivin, the release of cytochrome c, followed by procaspase-9, procaspase-3 and proPARP cleavage[1]. Hederagenin exhibits antiinflammatory activities via decreasing production of pro-inflammatory mediators (NO, PGE2, TNF-α, IL-1β, and IL-6) through suppression of the pathways of NF-κB in LPS-induced RAW264.7 cells[2].

Protocol

Cell Research:[1]
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  • Cell lines: LoVo cells
  • Concentrations: 0.25, 0.5, 1.0, 2.0 and 4.0 μM
  • Incubation Time: 24 or 48 h
  • Method: LoVo cells are seeded into 96-well plates at a density of 10,000 cells/well. After being treated with 0.25, 0.5, 1.0, 2.0 and 4.0 μM hederagenin for 24 or 48 h, the medium is discarded and treated with 20 μl MTT (5 mg/ml). After incubation for 4 h at 37°C, the 100 μl DMSO is added to each well to dissolve the resultant formazan crystals. Absorbance is detected at 490 nm.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 94 mg/mL (198.85 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 472.70
Formula

C30H48O4

CAS No. 465-99-6
Storage powder
in solvent
Synonyms Caulosapogenin, Hederagenol, Hederagenic acid, Astrantiagenin E
Smiles CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)CO)O)C)C)C2C1)C)C(=O)O)C

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID