D-(+)-Trehalose dihydrate

Catalog No.S3992

For research use only.

Trehalose is a non-reducing sugar. It is thought to provide plants and animals with the ability to withstanding periods of dehydration.

D-(+)-Trehalose dihydrate Chemical Structure

CAS No. 6138-23-4

Selleck's D-(+)-Trehalose dihydrate has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Trehalose is a non-reducing sugar. It is thought to provide plants and animals with the ability to withstanding periods of dehydration.
In vitro

Trehalose has been shown to play a key role in various types of stress-tolerance including radiation, cold and dehydration stresses in bacteria, yeast, nematodes, rotifers, tardigrades, certain crustaceans and insects. Studies on the role of trehalose in stress-tolerance suggest that trehalose must be presence on both sides of the cell membrane to confer protection. It is a non-charged and hydrophilic disaccharide which does not freely penetrate the mammalian cell membrane without external interventions[1].

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 75 mg/mL
(198.23 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 378.33
Formula

C12 H22O11 . 2H2O

CAS No. 6138-23-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(C1C(C(C(C(O1)OC2C(C(C(C(O2)CO)O)O)O)O)O)O)O.O.O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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