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Dehydroandrographolide Chloride Channel inhibitor

Cat.No.S3807

Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity.
Dehydroandrographolide Chloride Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 332.43

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Chemical Information, Storage & Stability

Molecular Weight 332.43 Formula

C20H28O4

 Storage (From the date of receipt)
CAS No. 134418-28-3 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CC12CCC(C(C1CCC(=C)C2CC=C3C=COC3=O)(C)CO)O

Solubility

In vitro
Batch:

DMSO : 66 mg/mL (198.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 33 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Mechanism of Action

Targets/IC50/Ki
TMEM16A [1]
In vitro
Dehydroandrographolide inhibits TMEM16A chloride currents in Fisher rat thyroid (FRT) cells that are transfected stably with human TMEM16A and in TMEM16A-overexpressed SW620 cells but does not alter cystic fibrosis transmembrane conductance regulator (CFTR) chloride currents. Further functional studies show that this compound suppresses the proliferation of SW620 cells in a dose- and time-dependent manner using MTT assays. It significantly inhibits migration and invasion of SW620 cells as detected by wound-healing and transwell assays. Moreover, treatment of SW620 cells with this chemical leads to a decrease in TMEM16A protein levels but has no effect on TMEM16A mRNA levels[1]. This compound induces autophagy in human oral cancer cells by modulating p53 expression, activating JNK1/2, and inhibiting Akt and p38. It is an iNOS inhibitor and an antiinflammatory and antiviral agent[2].
In vivo
Administration of dehydroandrographolide effectively suppresses the tumor formation in the oral carcinoma xenograft model in vivo[2].
References

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