Dehydroandrographolide

Catalog No.S3807

Dehydroandrographolide Chemical Structure

Molecular Weight(MW): 332.43

Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity.

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Biological Activity

Description Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity.
Targets
TMEM16A [1]
()
In vitro

Dehydroandrographolide inhibits TMEM16A chloride currents in Fisher rat thyroid (FRT) cells that are transfected stably with human TMEM16A and in TMEM16A-overexpressed SW620 cells but does not alter cystic fibrosis transmembrane conductance regulator (CFTR) chloride currents. Further functional studies show that dehydroandrographolide suppresses the proliferation of SW620 cells in a dose- and time-dependent manner using MTT assays. Dehydroandrographolide significantly inhibits migration and invasion of SW620 cells as detected by wound-healing and transwell assays. Moreover, treatment of SW620 cells with dehydroandrographolide leads to a decrease in TMEM16A protein levels but has no effect on TMEM16A mRNA levels[1]. Dehydroandrographolide induces autophagy in human oral cancer cells by modulating p53 expression, activating JNK1/2, and inhibiting Akt and p38. Dehydroandrographolide is an iNOS inhibitor and an antiinflammatory and antiviral agent[2].

In vivo Administration of dehydroandrographolide effectively suppresses the tumor formation in the oral carcinoma xenograft model in vivo[2].

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: SW620 cells
  • Concentrations: 5, 10, 20, 40 or 80 μM
  • Incubation Time: 24 h
  • Method: Cells (2 × 104 cells/ml) in the absence or presence of DP at different concentration are incubated for 24 h in 24-well tissue culture plates. At the end of the incubation period, the culture medium is removed and cells are washed with phosphate-buffered saline (PBS pH 7.4) and the cells are photographed under an inverted microscope at 100 × magnification.
    (Only for Reference)
Animal Research:[2]
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  • Animal Models: 5–6 week male BALB/c nude mice
  • Formulation: 0.5% carboxymethyl cellulose
  • Dosages: 40 or 100 mg/kg
  • Administration: oral
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 66 mg/mL (198.53 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 332.43
Formula

C20H28O4

CAS No. 134418-28-3
Storage powder
in solvent
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID