Home ER stress & UPR HSP inhibitor Pseudolaric Acid A

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Pseudolaric Acid A HSP inhibitor

Cat.No.E0249

Pseudolaric acid A, a Hsp90 inhibitor with an IC50 of 0.60 μM, 2.72 μM, 1.36 μM, 2.92 μM and 6.16 μM in HL-60, A549, SMMC-7721, HeLa and SW480 cells respectively, is the main bioactive ingredient in Pseudolarix cortex, and induces cell cycle arrest at G2/M phase and promotes cell death through caspase-8/caspase-3 pathway, demonstrating potent antiproliferation and anticancer activities.
Pseudolaric Acid A HSP inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 388.45

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: E024901 DMSO]78 mg/mL]false]]]false]]]false Purity: 99.78%
99.78

Chemical Information, Storage & Stability

Molecular Weight 388.45 Formula

C22H28O6

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 82508-32-5 -- Storage of Stock Solutions

Solubility

In vitro
Batch:

DMSO : 78 mg/mL (200.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Mechanism of Action

Targets/IC50/Ki
Hsp90 [1]
(in HL-60 cells cytotoxicity assay)
0.60 μM
Hsp90 [1]
(in SMMC-7721 cells cytotoxicity assay)
1.36 μM
Hsp90 [1]
(in A549 cells cytotoxicity assay)
2.72 μM
Hsp90 [1]
(in HeLa cells cytotoxicity assay)
2.92 μM
Hsp90 [1]
(in SW480 cells cytotoxicity assay)
6.16 μM
In vitro

Pseudolaric Acid A is more sensitive to leukemia P-388 and melanoma SK-MEL5, suggesting this compound deserves further development as potentially useful antitumor agent.[2]
References

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