For research use only.
Molecular Weight(MW): 270.24
Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.
Selleck's Baicalein has been cited by 9 publications
5 Customer Reviews
Baicalein suppresses the viability of DU 145 and PC-3 cells. b DU145 cells and c PC-3 cells were treated with different concentrations of baicalein for 24, 48, and 72 h. Baicalein significantly inhibited the viability of both cell lines in a dose-and time-dependent manner. The results are presented as the means ± SD of three independent experiments and the corresponding standard error. *P<0.05; **P<0.01.
Mol Cell Biochem, 2015, 406:111–119.. Baicalein purchased from Selleck.
NKILA stably overexpressed and control SMMC-7721 and HepG2 cells were treated with a series dose of Baicalein (0, 12.5, 25, 50, 100 μM) for 48 h. Then, cell proliferation was detected by Glo cell viability assays. The control condition was defined as media alone with no NKILA overexpression.
Chem Biol Interact, 2018, 285:48-58. Baicalein purchased from Selleck.
Baicalein downregulated BDLNR in dose and time dependent fashion in cervical cancer cells. (A, B) After being treated with indicated dose of baicalein for 24 h, BDLNR expression in HeLa (A) or SiHa (B) cells was measured by qRT-PCR and normalized to β-actin. (C, D) After being treated with 100 μM baicalein for indicated time, BDLNR expression in HeLa (C) or SiHa (D) cells was measured by qRT-PCR and normalized to β-actin. Results are shown as mean ± SD (n = 3). **P < 0.01, *** P < 0.001 by Student’s t test.
Int J Biochem Cell Biol, 2018, 94:107-118. Baicalein purchased from Selleck.
Baicalein activated PAX8-AS1-N expression in dose and time dependent manners in breast cancer cells. A and B, After treatment with indicated doses of baicalein for 48 h, PAX8-AS1-N expression in MDA-MB-231 (A) or MCF-7 (B) cells was measured by qRT-PCR and normalized to β-actin. C and D, After treatment with 200 µM baicalein for indicated time, PAX8-AS1-N expression in MDA-MB-231 (C) or MCF-7 (D) cells was measured by qRT‐PCR and normalized to β-actin. Results are shown as mean ± SD from three independent experiments. **P < 0.01, **P < 0.001 by Student's t-test.
J Cell Biochem, 2018, 119(8):6842-6856. Baicalein purchased from Selleck.
Purity & Quality Control
Choose Selective P450 (e.g. CYP17) Inhibitors
|Description||Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.|
|In vitro||DMSO||54 mg/mL (199.82 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+45% PEG 300+ddH2O
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
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Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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