Baicalein

Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.

Baicalein Chemical Structure

Baicalein Chemical Structure

CAS: 491-67-8

Selleck's Baicalein has been cited by 26 Publications

5 Customer Reviews

Purity & Quality Control

Batch: Purity: 99.5%
99.5

Baicalein Related Products

Choose Selective P450 (e.g. CYP17) Inhibitors

Biological Activity

Description Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor.
Targets
CYP2C9 [1]
In vitro
In vitro

Baicalein robustly inhibits stress-induced hypertrophy, by attenuating p38 signaling and PKD phosphorylation at serine 744/748 (S744/748), and downregulating signal transducer and activator of transcription 3 (STAT3).[2]

Cell Research Cell lines Neonatal rat ventricular myocytes (NRVMs)
Concentrations 10 μM
Incubation Time 48 h
Method

Neonatal rat ventricular myocytes (NRVMs) are stimulated to hypertrophy with phenylephrine (PE;10 M) in the absence or presence of vehicle control (Veh) or phytochemicals (apigenin (Api), baicalein (Bac), berberine hydrochloride (BHCl), emodin (Emod); All compounds are used at 10 μM) for 48 h. RNA is isolated and qPCR performed to analyze the natriuretic peptides (ANP and BNP), interleukins (IL-6, IL-1α, and IL-1β, CXC chemokine ligands (CXCL2 and CXCL6) and CC Chemokine ligands (CCL3 and CCL6).

In Vivo
In vivo

Baicalein exhibits a protective effect against LPS/D-gal-induced acute liver injury via suppressing NLRP3-mediated pro-inflammatory cytokines production.[3]

Animal Research Animal Models Nlrp3-/- (021302) mice, Gsdmd-/- (032410) mice, C57BL/6J WT mice
Dosages 30 mg/kg
Administration --

Chemical Information & Solubility

Molecular Weight 270.24 Formula

C15H10O5

CAS No. 491-67-8 SDF Download Baicalein SDF
Smiles C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 54 mg/mL ( (199.82 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Baicalein | Baicalein supplier | purchase Baicalein | Baicalein cost | Baicalein manufacturer | order Baicalein | Baicalein distributor