Home Apoptosis Apoptosis related activator - Fungal inhibitor Isoalantolactone

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Isoalantolactone Apoptosis related activator

Cat.No.S3829

Isoalantolactone, one of the major sesquiterpene lactone compounds, is isolated from the roots of Anula helenium and possesses multiple biological activities including antifungal, anthelmintic, antimicrobial, anti-inflammatory, antitrypanosomal activities and antiproliferative effects on several cancer cell lines, such as colon, melanoma, ovary, prostate, lung, and leukemia. This compound is an apoptosis inducer, which also acts as an alkylating agent.
Isoalantolactone Apoptosis related activator Chemical Structure

Chemical Structure

Molecular Weight: 232.32

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S382901 DMSO]46 mg/mL]false]]]false]]]false Purity: 99.99%
99.99

Chemical Information, Storage & Stability

Molecular Weight 232.32 Formula

C15H20O2

 Storage (From the date of receipt)
CAS No. 470-17-7 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CC12CCCC(=C)C1CC3C(C2)OC(=O)C3=C

Solubility

In vitro
Batch:

DMSO : 46 mg/mL (198.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

In vitro
Isoalantolactone inhibits growth and induces apoptosis in pancreatic cancer cells. This compound increases the expression of phosphorylated p38 MAPK, Bax, and cleaved caspase-3 and decreases the expression of Bcl-2 in a dose-dependent manner[1]. This chemical treatment in HeLa cancer cells exhibits cytotoxicity in a dose-dependent manner with a low IC50 value of 8.15 ± 1.16 μM[2].
In vivo
Isoalolactone does not induce any acute or chronic toxicity in liver and kidneys of CD1 mice at dose of 100 mg/kg body weight[1]. This compound is distributed and eliminated rapidly possibly due to its low-polarity characteristic. A large apparent volume of distribution (138.44 ± 54.14 L) suggests that the lactones may accumulate in certain organs with high concentration after intravenous injection[3].
References

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