Name: Schisandrin B
Brand: Selleck Chemicals
SKU: S3600
Availability: InStock
Rating: 5 (11 reviews)

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Quality Control

Batch: Purity: 99.98%

99.98

Related Targets	PI3K Akt mTOR GSK-3 DNA-PK AMPK PDPK1 PTEN PP2A PDK
Other ATM/ATR Inhibitors	Ceralasertib (AZD6738) AZD1390 Berzosertib (VE-822) Lartesertib (M4076) Camonsertib (RP-3500) KU-60019 KU-55933 VE-821 AZ20 AZD0156

Solubility

In vitro
Batch:

DMSO : 80 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	4.000mg/ml (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 80 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	4.000mg/ml (9.99mM)	Taking the 1 mL working solution as an example, add 50 μL of 80 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	400.46	Formula	C₂₃H₂₈O₆	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	61281-37-6	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

Targets/IC₅₀/Ki	P-gp (Cell-based assay) ATR 7.25 μM
In vitro	Schisandrin B is able to induce high level of apoptosis in human hepatic carcinoma cells and human leukemia cells. This compound decreases the viability of adenocarcinoma cells after UV exposure. The specific inhibitory effect of this compound on ATR protein kinase activity (a DNA repair enzyme) following DNA damage in cells may be useful in anti-cancer therapy. It is found to be the only molecule being a cardioprotective agent as well as a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1, which is potentially applicable to treat cancers, especially those displaying multidrug resistance.
In vivo	Schisandrin B can protect liver against toxicant challenge. This compound pretreatment protects against carbon tetrachloride- or TNFα-induced liver damage in mice. Further studies demonstrate the protective effect of this chemical on free radical-induced damage in various vital organs, including the heart, liver, kidney, brain and skin. Moreover, it is found to attenuate cancer invasion and metastasis via inhibiting epithelial mesenchymal transition at the step of local invasion.
References	[1] https://pubmed.ncbi.nlm.nih.gov/15378770/ [2] https://pubmed.ncbi.nlm.nih.gov/19625493/ [3] https://pubmed.ncbi.nlm.nih.gov/16084496/ [4] https://pubmed.ncbi.nlm.nih.gov/7480197/ [5] https://pubmed.ncbi.nlm.nih.gov/8891674/ [6] https://pubmed.ncbi.nlm.nih.gov/11525242/ [7] https://pubmed.ncbi.nlm.nih.gov/16889754/ [8] https://pubmed.ncbi.nlm.nih.gov/21111034/ [9] https://pubmed.ncbi.nlm.nih.gov/22848381/ [10] https://pubmed.ncbi.nlm.nih.gov/16084496/

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Schisandrin B ATM/ATR inhibitor

Chemical Structure

Molecular Weight: 400.46