Schisandrin B (Sch B)
For research use only.
Molecular Weight(MW): 400.46
Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.
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|Description||Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.|
Schisandrin B is able to induce high level of apoptosis in human hepatic carcinoma cells and human leukemia cells.  Schisandrin B decreases the viability of adenocarcinoma cells after UV exposure. The specific inhibitory effect of schisandrin B on ATR protein kinase activity (a DNA repair enzyme) following DNA damage in cells may be useful in anti-cancer therapy.  Schisandrin B is found to be the only molecule being a cardioprotective agent as well as a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1, which is potentially applicable to treat cancers, especially those displaying multidrug resistance.  
|In vivo||Schisandrin B can protect liver against toxicant challenge. Schisandrin B pretreatment protects against carbon tetrachloride- or TNFα-induced liver damage in mice.    Further studies demonstrate the protective effect of schisandrin B on free radical-induced damage in various vital organs, including the heart, liver, kidney, brain and skin.  Moreover, schisandrin B is found to attenuate cancer invasion and metastasis via inhibiting epithelial mesenchymal transition at the step of local invasion. |
-  Wu YF, et al. World J Gastroenterol, 2004, 10(20), 2944-2948.
-  Nishida H, et al. Nucleic Acids Res, 2009, 37(17), 5678-5689.
-  Qiangrong P, et al. Biochem Biophys Res Commun, 2005, 335(2), 406-411.
-  Wan CK, et al. Biochem Pharmacol, 2006, 72(7), 824-837.
-  Ip SP, et al. Planta Med, 1995, 61(5), 398-401.
-  Ip SP, et al. Free Radic Biol Med, 1996, 21(5), 709-712.
-  Ip SP, et al. Cell Stress Chaperones, 2001, 6(1), 44-48.
-  Lam PY, et al. Fitoterapia, 2011, 82(2), 393-400.
-  Liu Z, et al. PLoS One, 2012, 7(7), e40480.
-  Qiangrong P, et al. Biochem Biophys Res Commun. 2005, 335(2):406-11.
|In vitro||DMSO||80 mg/mL (199.77 mM)|
|Ethanol||10 mg/mL (24.97 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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