Schisandrin B (Sch B)
Molecular Weight(MW): 400.46
Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.
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|Description||Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. It is a kind of ATR and P-gp inhibitor with high safety.|
Schisandrin B is able to induce high level of apoptosis in human hepatic carcinoma cells and human leukemia cells.  Schisandrin B decreases the viability of adenocarcinoma cells after UV exposure. The specific inhibitory effect of schisandrin B on ATR protein kinase activity (a DNA repair enzyme) following DNA damage in cells may be useful in anti-cancer therapy.  Schisandrin B is found to be the only molecule being a cardioprotective agent as well as a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1, which is potentially applicable to treat cancers, especially those displaying multidrug resistance.  
|In vivo||Schisandrin B can protect liver against toxicant challenge. Schisandrin B pretreatment protects against carbon tetrachloride- or TNFα-induced liver damage in mice.    Further studies demonstrate the protective effect of schisandrin B on free radical-induced damage in various vital organs, including the heart, liver, kidney, brain and skin.  Moreover, schisandrin B is found to attenuate cancer invasion and metastasis via inhibiting epithelial mesenchymal transition at the step of local invasion. |
-  Wu YF, et al. World J Gastroenterol, 2004, 10(20), 2944-2948.
-  Nishida H, et al. Nucleic Acids Res, 2009, 37(17), 5678-5689.
-  Qiangrong P, et al. Biochem Biophys Res Commun, 2005, 335(2), 406-411.
-  Wan CK, et al. Biochem Pharmacol, 2006, 72(7), 824-837.
-  Ip SP, et al. Planta Med, 1995, 61(5), 398-401.
-  Ip SP, et al. Free Radic Biol Med, 1996, 21(5), 709-712.
-  Ip SP, et al. Cell Stress Chaperones, 2001, 6(1), 44-48.
-  Lam PY, et al. Fitoterapia, 2011, 82(2), 393-400.
-  Liu Z, et al. PLoS One, 2012, 7(7), e40480.
-  Qiangrong P, et al. Biochem Biophys Res Commun. 2005, 335(2):406-11.
|In vitro||DMSO||80 mg/mL (199.77 mM)|
|Ethanol||10 mg/mL (24.97 mM)|
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