Catalog No.S3612 Synonyms: Rosemary acid
Molecular Weight(MW): 360.31
Rosmarinic acid (RA) is a naturally occurring hydroxylated compound. It has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling.
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|Description||Rosmarinic acid (RA) is a naturally occurring hydroxylated compound. It has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling.|
RA exerts a significant cytoprotective effect by scavenging intracellular ROS induced by UVB. RA also attenuates UVB-induced oxidative macromolecular damage, including protein carbonyl content, DNA strand breaks, and the level of 8-isoprostane. Furthermore, RA increases the expression and activity of superoxide dismutase, catalase, heme oxygenase-1, and their transcription factor Nrf2, which are decreased by UVB radiation. RA treatment recovers the protein expression levels of Nrf2 decreased by UVB exposure, and results in the translocation of Nrf2 protein from the cytosol into the nucleus. RA may protect cellular environments from free-radical damage and thereby, enhance the cellular antioxidant defense system. Rosmarinic acid inhibits TNF-α-induced phosphorylation and degradation of IκB-α, as well as nuclear translocation of NF-κB heterodimer induced by TNF-α. It downregulates the expression of CCL11 and CCR3 via the inhibition of NF-κB activation signaling. Rosmarinic acid inhibits the Ca2+-dependent pathways of TCR-mediated signaling by inhibiting PLC-γ1 and Itk activities.
|In vivo||RA improves histological and serum markers of liver damage and significantly ameliorates oxidative/nitrosative stress and inflammatory response in liver tissue. Additionally, RA prevents transforming growth factor-beta1 (TGF-b1) and alpha-smooth muscle actin (a-SMA) expression, suggesting suppression of profibrotic response. RA significantly inhibits the CCl4-induced apoptosis, which is evident from decreased cleavage of caspase-3. The hepatoprotective activity of RA coincides with enhanced NF-E2-related factor 2 (Nrf2) and hemeoxygenase-1 (HO-1) expression. Rosmarinic acid acts as a natural inducer of endogenous cellular antioxidant defense via activation of the Nrf2/HO-1 pathway.|
|In vitro||DMSO||72 mg/mL (199.82 mM)|
|Ethanol||72 mg/mL (199.82 mM)|
|Water||24 mg/mL (66.6 mM)|
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