Home Metabolism Drug Metabolite chemical Imidacloprid-urea

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Imidacloprid-urea Drug Metabolite chemical

Cat.No.S4448

Imidacloprid-urea with a role as a marine xenobiotic metabolite, is the primary imidacloprid soil metabolite, whereas imidacloprid-olefin is the main plant-relevant metabolite and is more toxic to insects than imidacloprid.
Imidacloprid-urea Drug Metabolite chemical Chemical Structure

Chemical Structure

Molecular Weight: 211.65

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Quality Control

Batch: S444801 DMSO]42 mg/mL]false]Ethanol]21 mg/mL]false]Water]5 mg/mL]false Purity: 98.95%
98.95

Solubility

In vitro
Batch:

DMSO : 42 mg/mL (198.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 21 mg/mL

Water : 5 mg/mL

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 211.65 Formula

C9H10ClN3O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 120868-66-8 -- Storage of Stock Solutions

Synonyms N/A Smiles ClC1=CC=C(CN2CCNC2=O)C=N1

Mechanism of Action

In vitro

Imidacloprid urea is a metabolite of imidacloprid. Imidacloprid is an effective and widely used neonicotinoid pesticide to control pests of cereals, vegetables, tea and cotton. Imidacloprid can reduce insulin stimulated glucose uptake in adipocytes (3T3-L1), hepatocytes (HepG2), and myotubes (C2C12) cell culture models. Treatment with imidacloprid inhibits phosphorylation of protein kinase B (AKT) and ribosomal S6 kinase (S6K).
In vivo

The brain, liver and kidney of rats exposed with high dose of imidacloprid(20mg/kg/day) show mild pathological changes.

References

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