||(-)-Arctigenin, a lignan found in certain plants of the Asteraceae, exerts biological activities including anti-inflammatory, antiviral and anticancer.
||(6-)ε-Aminocaproic acid is a derivative and analogue of the amino acid lysine.
(Ala13)-Apelin-13 is a potent APJ receptor antagonist and can prevent the apelin-induced reduction in gastric tone and motility.
||1-Aminobenzotriazole (ABT, 3-Aminobenzotriazole, 1-Benzotriazolylamine, NSC 114498, NSC 656987) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. 1-Aminobenzotriazole is also a substrate and inhibitor of N-acetyltransferase (NAT).
||1-Azakenpaullone (1-Akp) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.
||1588-A4 (ARS-1620 Intermediate) is the ARS-1620 intermediate. ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
2-Acetamidofluorene (2-AAF, 2-Acetaminofluorene, N-2-Fluorenylacetamide, N-Acetyl-2-aminofluorene) is a carcinogenic and mutagenic compound.
||2-Acetylphenothiazine (ML171, 2-APT) is a potent and selective inhibitor of NADPH-oxidase with IC50s of 0.25 μM, 5 μM, 3μM, 5 μM and 5.5 μM for NOX1, NOX2, NOX3, NOX4 and xanthine oxidase, respectively.
||2-Acetylpyrazine is one of the volatile flavor constituents in popcorn, wheat and rye bread crust.
2-Amino-1-phenylethanol (2-APE) is a noradrenaline analogue.
||2-Amino-N-quinolin-8-yl-benzenesulfonamide (NUN82647, QBS, CU-242) is an inhibitor of cell cycle at G2 phase and apoptosis inducer.
2-Aminoacridone is a highly fluorescent aromatic.
||2-Aminobenzenesulfonamide (Orthanilamide, O-Aminobenzenesulfonamide, O-Sulfanilamide, Benzenesulfonamide) is an inhibitor of carbonic anhydrase IX.
||2-Aminobenzenesulfonic acid (Orthanilic acid, O-Aminobenzenesulfonic acid, Aniline-2-sulfonic acid) is a biological acid with roles in benzoate degradation and microbial metabolism in diverse environments.
||2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.
||2-Aminoethyl Diphenylborinate (2-APB)
||2-Aminoethyl Diphenylborinate (2-APB) is an IP3 receptor inhibitor and regulate IP3-induced calcium release.2-APB also inhibits the SOC channel activity and activates TRP channel at higher concentrations.
2-Aminoethylphosphonic acid (2-AEP, (2-Aminoethyl)phosphonic acid) is a type of abundant and ubiquitous naturally occurring phosphonate used as sources of phosphorus by many prokaryotic lineages.
||2-Aminoheptane (Tuaminoheptanez, Tuamine, Heptamine, 1-Methylhexylamine, 2-Heptylamine) is a nasal decongestant drug which is a sympathomimetic stimulant and vasoconstrictor.
||2-Aminoisobutyric acid (NSC-16590, 2-Methylalanine, H-Aib-OH) is a rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin.
||3-Amino-1,2,4-triazole (1,2,4-Triazol-3-amine, 3-AT, Aminotriazole, Amitrol, 3-Amino-1H-1,2,4-triazole, Trapidil impurity B) is a common irreversible inhibitor of catalase, induces a compensatory mechanism for the hydrogen peroxide detoxification, which includs a rise in glutathione peroxidase (GPX) and glutathione reductase activities.
||3-Amino-4-hydroxybenzoic acid is a monohydroxybenzoic acid.
||3-Amino-4-methylpentanoic acid (beta-Leucine, DL-Homovaline, DL-beta-leucine, beta-Aminoisocaproic acid) is a human metabolite.
||3-Aminobenzamide (3-ABA , 3-Amino Benzamide, 3-AB) is a potent inhibitor of Poly(ADP-ribose)polymerase (PARP) and inhibits cell apoptosis after SCI (Spinal Cord Injury) in caspase-independent way.
||3-Aminoisobutyric acid (3-Amino-2-methylpropanoic acid, 3-Aminoisobutyrate, β-aminoisobutyric acid) is a product formed by the catabolism of thymine.
||3-Aminopropionitrile fumarate (Beta-Aminopropionitrile fumarate) is an organic compound and antirheumatic agent used in veterinary medicine.
4-Acetamidobutanoic acid (N-acetyl GABA) is a derivative of Gamma-aminobutyric acid (GABA) resulting from the monoacetylation of the nitrogen of GABA.
||4-Allylanisole (Estragole, p-Allylanisole, Methyl chavicol) is a natural organic compound that is a component of various trees and plants. It is used in the preparation of fragrances.
||4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.
||4-Aminobenzohydrazide (4-Aminobenzhydrazide, 4-aminobenzoic acid hydrazide, 4-ABAH, Myeloperoxidase Inhibitor I, NSC 640) is an inhibitor of MPO (Myeloperoxidase) enzyme that enhances iNOS induction in MPO-positive cells, but not in MPO-KO cells.
||4-Aminobenzoic acid (para-Aminobenzoic acid) is an intermediate in the synthesis of tetrahydrofolic acid in many non-mammalian organisms, including bacteria and fungi.
||4-Aminobutyric acid (GABA)
||4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid) is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity.
||4-aminophenol (p-aminophenol) is a metabolite of compounds such as acetaminophen (paracetamol) and azo dyes that has been shown to be toxic to mammalian cells.
||4-Aminophenylarsonic acid (Arsanilic Acid) is an organoarsenic compound with activity as an anti-infective agent.
||4-Aminopyridine (4-AP, Fampridine, Dalfampridine) is a potent and non-selective inhibitor of voltage gated potassium channels (Kv) with IC50 values of 170 μM and 230 μM for Kv1.1 and Kv1.2 in CHO cells, respectively.
||4-Aminosalicylic acid (Para-aminosalicylic acid, Aminosalicylic acid, 4-aminosalicylate) is an antitubercular agent with bacteriostatic activity against Mycobacterium tuberculosis.
||AMP, also known as 5'-Adenylic acid and Adenosine monophosphate, is a nucleotide that is found in RNA. It is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet.
||5-Acetylsalicylic acid (5-acetyl-2-hydroxybenzoic acid) is a nonsteroidal anti-inflammatory drug.
||5-Aminolevulinic acid HCl
||5-Aminolevulinic Acid HCl is an intermediate in the porphyrin synthesis pathway, used as a photosensitizing agent and a antineoplastic agent.
||5a-Pregnane-3,20-dione (5alphaP, 5-a-dihydroprogesterone, 3,20-allopregnanedione, 5-Alpha-Dihydro Progesterone) is the endogenous progesterone metabolite. 5a-Pregnane-3,20-dione depolymerizes actin and decreases expression of actin and vinculin. 5a-Pregnane-3,20-dione is involved in promoting breast neoplasia and metastasis by affecting adhesion and cytoskeletal molecules.
||5alpha-Cholestan-3-one (Coprostanone) is a substrate of cholestenone 5alpha-reductase.
||6-Acetamidohexanoic acid (6-Acetamidocaproic acid) is a pharmaceutical intermediate.
||6-Aminonicotinamide (6AN) is an antimetabolite used to inhibit the NADPH-producing pentose phosphate pathway (PPP) in many cellular systems, making them more susceptible to oxidative stress. 6-Aminonicotinamide is a competitive inhibitor of NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) with Ki of 0.46 μM.
||6-Aminopenicillanic acid (6-APA) is the central component of penicillin β-lactam antibiotics which are generated by Penicillium. It is used as precursor for antibiotic compounds ampicillin and amoxicillin.
||7-Aminocephalosporanic acid is used for synthesis of cephalosporin antibiotics and intermediates.
||7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells.
||8-Aminooctanoic acid is a chemical.
||9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin.
||9-Aminoacridine (Aminacrine) is a highly fluorescent dye used clinically as a topical antiseptic and experimentally as a mutagen, an intracellular pH indicator and a negative mode small molecule MALDI matrix.
||A 77-01 is a potent inhibitor of TGF-β1 receptor ALK5 with IC50 of 25 nM.
||A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).
||A-1331852 is a potent and selectiveBCL-XL inhibitor with Ki value less than 0.01 nM for BCL-XL and 6 nM, 4 nM, 142 nM for Bcl-2, Bcl-W, MCL-1 respectively. It may be useful in the treatment of cancer, immune and autoimmune diseases.
||A-317491 is a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors.
||A-381393 is a potent, selective, brain-penetrate antagonist of dopamine D4 receptor with Ki of 1.5 nM, 1.9 nM and 1.6 nM for human dopamine D4.4, D4.2 and D4.7 receptor, respectively. A-381393 shows moderate affinity for 5-HT2A with Ki of 370 nM.
||A-485 is a potent, selective and drug-like p300/CBP catalytic inhibitor with an IC50 of 0.06 μM for p300 HAT. It is selective over BET bromodomain proteins and >150 non-epigenetic targets.
||A-740003 is a potent, selective and competitive antagonist of P2X7 receptor with IC50 of 18 nM and 40 nM for rat and human P2X7 receptors, respectively. A-740003 potently blocks agonist-evoked IL-1β release and pore formation with IC50 of 156 nM and 92 nM in differentiated human THP-1 cells.
||A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity.
A-779 is a potent and selective antagonist for Angiotensin-(1–7) (Ang-(1-7)) with an IC50 of 0.3 nM in a radioligand binding assay. A-779 shows no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM.
||A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM, blocks tetrodotoxin-resistant currents, exhibits >100-fold selectivity against human NaV1.2, NaV1.3, NaV1.5, and NaV1.7.
||A-83-01 is a potent inhibitor of TGF-β type I receptor (ALK5-TD) with IC50 of 12 nM. A-83-01 also inhibits the transcription induced by activin/nodal type I receptor (ALK4-TD) and nodal type I receptor (ALK7-TD) with IC50 of 45 nM and 7.5 nM, respectively.Solutions are best fresh-prepared.
||A-RAF Rabbit Recombinant mAb
||A-RAF Rabbit Recombinant mAb detects endogenous levels of total A-RAF.
||A1120 is an antagonist of retinol-binding protein 4 (RBP4) with Ki of 8.3 nM. A1120 disrupts the interaction between RBP4 and its binding partner transthyretin.
||A1874 is a much improved nutlin-based, BRD4-degrading PROTAC and is able to degrade its target protein by 98% with nanomolar potency.
||A2764 dihydrochloride is a selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1) with IC50 of 11.8 μM for the activated mTRESK channel. A2764 dihydrochloride has the potential for probing the role of TRESK channel in migraine and nociception.
||A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is an efficient inhibitor of TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK.
||A-286982 is a potent, nonpeptide inhibitor of LFA-1/ICAM-1 interaction with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding assay and LFA-1-mediated cellular adhesion assay, respectively.
||A922500 (DGAT-1 Inhibitor 4a) is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.
||A939572 is a potent and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 of <4 nM and 37 nM for mSCD1 and hSCD1, respectively.
||AA26-9 is a potent and broad spectrum inhibitor of Serine hydrolases (SHs).
AA38-3 is a serine hydrolase (SH) inhibitor that inhibits three SHs, ABHD6, ABHD11, and FAAH.
||AA41612 is an antagonist of melanopsin-mediated phototransduction.
||AA92593 is a selective antagonist of Melanopsin (OPN4) which is a photo-pigment found in a small subset of intrinsically photosensitive ganglion cells (ipRGCs) of the mammalian retina.
||AB-423, a member of the sulfamoylbenzamide (SBA) class of hepatitis B virus (HBV) capsid inhibitors, shows potent inhibition of HBV replication with EC50 of 0.08 μM - 0.27 μM and EC90 of 0.33 μM - 1.32 μM in cells. Phase 1.
||Abacavir (1592U89, ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.
||Abacavir (1592U89) is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.
Abaloparatide (BA058, BIM-44058, ITM-058) is a novel 34-amino acid peptide selected to be a potent and selective activator of the parathyroid hormone receptor (PTH1R) signaling pathway with an IC50 of 0.117 nM in SOST analysis.
||Abametapir (HA-44, BRN 0123183), the active ingredient of Xeglyze Lotion, is an inhibitor of metalloproteinases critical for louse survival and egg development.
||Abatacept (Orencia, CTLA4lg, BMS-188667) is a recombinant DNA generated fusion protein that comprises the extracellular domain of human CTLA-4 fused to the Fc portion of human IgG1 and antagonizes CD28-mediated T cells.
||ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It is developed for treating AML and cancers.
||ABCF1 Rabbit Recombinant mAb
||ABCF1 Rabbit Recombinant mAb detects endogenous level of total ABCF1.
||Abemaciclib (LY2835219) is a cell cycle inhibitor selective for CDK4/6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively.
||Abemaciclib mesylate (LY2835219)
||Abemaciclib (LY2835219) is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.
||Abexinostat (PCI-24781, CRA-024781) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2.
||Abietic acid (Sylvic acid, Abietate, Rosin Acid), an abietane diterpenoid, inhibited soybean 5-lipoxygenase with an IC50 of 29.5 ± 1.29 μM.
||Abiraterone (CB-7598) is a potent CYP17 inhibitor with IC50 of 2 nM in a cell-free assay. Abiraterone (CB-7598) is an androgen biosynthesis inhibitor.
||Abiraterone Acetate (CB7630)
||Abiraterone Acetate (CB7630) is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM in a cell-free assay. Abiraterone acetate is an oral androgen biosynthesis inhibitor.
||Abrocitinib (PF-04965842) is a potent JAK1 inhibitor with IC50s of 29 nM, 803 nM, > 10 000 nM and 1250 nM for JAK1, JAK2, JAK3 and tyrosine kinase (TYK) 2, respectively.
||Abscisic Acid (Dormin)
||Abscisic Acid (Dormin, Abscisin II) is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and seedling growth.
||Absinthin (Absynthine) is a naturally produced triterpene lactone from Artemisia absinthium with anti-inflammatory properties. Absinthin significantly enhances the expression of matrix metalloproteinase-8 (MMP-8) and is a possible treatment candidate for Acute lung injury (ALI).
||ABT 702 dihydrochloride
||ABT-702 is a novel, potent non-nucleoside Adenosine kinase inhibitor with an IC50 of 1.7 nM. It has oral activity in animal models of pain and inflammation.
||ABT-724 is a potent and highly selective agonist of dopamine D4 receptor with EC50 of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 and the ferret D4 receptor, respectively. ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 is useful for the treatment of erectile dysfunction and has favorable side-effect profile.
||ABT-724 trihydrochloride is a potent and highly selective agonist of dopamine D4 receptor with EC50 of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 and the ferret D4 receptor, respectively. ABT-724 trihydrochloride has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride is useful for the treatment of erectile dysfunction and has favorable side-effect profile.
||ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ABT-737 induces mitochondrial pathway apoptosis and mitophagy. Phase 2.
||ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.
||ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.
||ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively.
||ABX464 (SPL-464) is a novel anti-HIV molecule that inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) from 5 different donors with IC50 ranging between 0.1 μM and 0.5 μM.
||Ac-Arg-OH (N-Acetyl-L-arginine) is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population.
||Ac-DEVD-CHO (Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO) is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2.
||Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases. Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively.
||AC1903 (compound 2) is a specific and selective TRPC5 (transient receptor potential canonical channel 5) inhibitor with IC50 of 4.06 μM.
||AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1.
AC710 is a potent PDGFR family inhibitor with IC50s of 1.2 nM, 2 nM, 7.7 nM and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively. AC710 exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450.
||Acacetin (Linarigenin, 5,7-dihydroxy-4'-methoxyflavone, 4'-Methoxyapigenin) is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects.
||Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.
||Acalisib (GS-9820, CAL-120) is a highly selective and potent p110δ inhibitor (IC50 = 14 nM) with 114- to 400-fold selectivity over the other class I PI3K enzymes and no activity against Class II and III PI3K family members or other PI3K-related proteins including mTOR and DNA-PK.
||Acamprosate (N-Acetylhomotaurine, Calcium acetylhomotaurinate), is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine.
||Acarbose(BAY g 5421) is an inhibitor of intestinal alpha-glucosidase, used to treat type 2 diabetes mellitus.
||ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.
||Acebutolol is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.
||Aceclofenac (Preservex, Airtal) is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.
||Aceglutamide (α-N-Acetyl-L-glutamine, N2-Acetylglutamine) is a psychostimulant, nootropic agent which functions as a prodrug to glutamine with improved potency and stability.
||Acelarin (NUC-1031, Fosgemcitabine palabenamide, CPF-31, MTL-007, GTPL7389), a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine, is a DNA synthesis inhibitor with EC50 of 0.2 nM.
||Acemetacin (K-708) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
||Acesulfame potassium is a non-nutritive sweetener.
||Acetamide (ethanamide, Acetic acid amide) is an organic compound that can be used as a plasticizer and an industrial solvent.
||Acetanilide is an aniline derivative and has possess analgesic.
||Acetazolamide (Diamox), a potent carbonic anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure(IOP).
||Acetic acid octyl ester
Acetic acid octyl ester (Octyl acetate) is one of the major components of essential oils in the vittae, or oil tubes, of the wild parsnip (Pastinaca sativa). Acetic acid octyl ester exhibits antioxidant activity.
||Acetohexamide is an intermediate-acting, first-generation oral sulfonylurea with hypoglycemic activity. It exerts the blood-glucose-lowering effects by stimulating the pancreatic beta cells to secrete insulin and by helping the body use insulin efficiently.
||Acetohydroxamic acid (N-Hydroxyacetamide, Methylhydroxamic acid, Acetic acid|oxime, Lithostat) is an Urease Inhibitor. In the urine, it acts as an antagonist of the bacterial enzyme urease.
||Acetoin is an important physiological metabolite excreted by many microorganisms. It is widely used in food and cosmetic industry as taste and fragrance enhancer.
||Acetophenone (Methyl phenyl ketone, Phenylethanone) is an organic compound used as fragrances and a raw material for the synthesis of some pharmaceuticals.
||Acetosyringone (Acetosyringenin) is a phenolic natural product with analgesic, antipyretic and anti-inflammatory actions.
||Acetyl Resveratrol is the derivative compound of resveratrol, which is a potent phenolic antioxidant found in grapes and red wine.
||The chemical compound Acetylcholine Chloride is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.
||Acetylcholine iodide (Acetylcolina) is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
||Acetylcorynoline, a major alkaloid component derived from Corydalis bungeana which is a traditional Chinese medical herb, shows anti-inflammatory properties. Acetylcorynoline may decrease egl-1 expression to suppress apoptosis pathways and increase rpn5 expression to enhance the activity of proteasomes.
||Acetylcysteine (N-acetyl-l-cysteine, NAC) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine(N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine(N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine(N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions of Acetylcysteine are best fresh-prepared.
||Acetylisovaleryltylosin tartrate (AK105039) is an antimicrobial of the macrolide group with antibacterial activity against Gram-positive bacteria.
||Acetylleucine (N-acetyl-L-leucine) is a drug used in the treatment of vertigo.
||Acetylspiramycin (ASPM, Spiramycin II, Foromacidin B) is a macrolide antimicrobial agent.
||Acetylvanillin (Acetovanillin, Vanillin acetate, 4-Acetoxy-3-methoxybenzaldehyde, 4-Formyl-2-methoxyphenyl acetate), is found in pulses and is a flavouring material.
ACH-000143 is a potent melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively.
||Aciclovir (BW 248U)
||Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.
||Acid orange 7
||Acid orange 7 (2-naphthol orange, Orange II, CI 15510, D&C Orange 4, COLIPA C015) is an azo dye used for dyeing wool.
||Acid Red 27
||Acid Red 27 (Azorubin S, Amaranth) is a modified red azo dye used as a food dye and to color cosmetics.
||Acid Yellow 23
||Acid Yellow 23 is a popular colorant for multiple applications, commonly used in ink, pond dyes, and textiles.
||Acid Yellow 36
||Acid Yellow 36 (Metanil Yellow) is a dye of the azo class and used as a pH indicator and it has a color change from red to yellow between pH 1.2 and 2.3.
||Acipimox (Olbemox) is a niacin derivative used as a hypolipidemic agent.
||Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.
||Aclidinium Bromide (LAS 34273, LAS-W 330) inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.
||Acotiamide (Acofide, Z388) is a novel acetylcholinesterase inhibitor with fundus-relaxing and gastroprokinetic properties.
||Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor.
||ACP-105 is an orally available and potent selective androgen receptor modulator (SARM) with pEC50 of 9.0 and 9.4 for AR wild type and AR mutation T877A, respectively.
||Acrivastine is an antihistamine medicine that relieves the symptoms of allergies.
||Acrylamide is a neurotoxic monomer with extensive industrial applications. It could be used as a precursor to polyacrylamides.
||ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2). ACSS2 inhibitor also inhibits the respiratory syncytial virus (RSV).
||ACT-389949 is a potent, selective agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX) with EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for inflammatory disorders.
||ACT-678689 (Compound Example 1.53.4) is an inhibitor of tryptophan hydroxylase (TPH) with IC50 of 8 nM.
||Actarit (4-acetylaminophenylacetic acid) is an orally active immunomodulator used in the treatment of rheumatoid arthritis.
||ACVRL1 Rabbit Recombinant mAb
||ACVRL1 Rabbit Recombinant mAb detects endogenous level of total ACVRL1.
||ACY-738 inhibits HDAC6 with low nanomolar potency (IC50=1.7 nM) and a selectivity of 60- to 1500-fold over class I HDACs.
||ACY-775 is a potent and selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.5 nM.
||AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.
||Adagrasib (MRTX849) is a potent, selective, and covalent KRASG12C inhibitor that exhibits favorable drug-like properties, selectively modifies mutant cysteine 12 in GDP-bound KRASG12C and inhibits KRAS-dependent signaling.
||Adalimumab (anti-TNF-alpha) is the first fully human, recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha, MW: 144.19 KD.
||ADAM10 Rabbit Recombinant mAb
||ADAM10 Rabbit Recombinant mAb detects endogenous level of total ADAM10.
Adamantane is a colorless, crystalline chemical compound first isolated from petroleum with a camphor-like odor. Adamantane is used to treat influenza A virus infections.
||Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne.
||Adaptavir (DAPTA, D-Ala-peptide T-amide, peptide T) is a water soluble potent, selective CCR5 antagonist which potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5.
||Adavivint (SM04690) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ∼150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.
||Adavosertib (MK-1775, AZD1775) is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint. Phase 2.
||Adefovir is an orally administered nucleotide analog reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection.
||Adefovir Dipivoxil (GS 0840)
||Adefovir Dipivoxil (GS 0840) is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV).
||Adelmidrol is an analogue of palmitoylethanolamide (PEA) with anti-inflammatory activities.
||Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.
||Ademetionine disulfate tosylate
||Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.
||Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry.
||Adenine HCl is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
||Adenine sulfate is a sulfate salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
||Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.
||Adenosine 5'-monophosphate monohydrate
||Adenosine 5'-monophosphate monohydrate (5'-Adenylic acid, 5'-AMP) is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK).
||Adenosine 5′-diphosphate sodium salt
||Adenosine 5′-diphosphate (ADP, Adenosine diphosphate, Adenosine 5′-pyrophosphate, Adenosine pyrophosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells. ADP can be interconverted to adenosine triphosphate (ATP) and adenosine monophosphate (AMP).
||Adenosine Cyclophosphate (Cyclic adenosine monophosphate, cAMP, cyclic AMP, 3',5'-cyclic adenosine monophosphate) is useful for improving myocardial hypoxia, dilating coronary artery and strengthening myocardiac contraction.
||Adenosine Dialdehyde (ADOX)
||Adenosine Dialdehyde (ADOX) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM.
||Adenosine disodium triphosphate
||Adenosine disodium triphosphate (ATP disodium) is the sodium salt form of adenosine triphosphate (ATP), a complex organic chemical that provides energy to drive many processes in living cells.
||Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.
||ADH-503 (GB1275, (Z)-Leukadherin-1 choline) is the salt form of leukadherin-1 and acts as a potent allosteric agonist of CD11b.
||Adipamidoxime (NSC 70868)
||Adipamidoxime (NSC 70868) is a new bioactive compoud.
||Adiphenine HCl is a nicotinic receptor inhibitor, used as an antispasmodic drug.
||Adipic acid (Hexanedioic acid) is an important dicarboxylic acid used for the manufacture of nylon and polyurethane plastics.
||AdipoRon (SC-396658) is a novel, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively.
||Adjudin (AF-2364), a potent male contraceptive, is a potent blocker of Cl⁻ channels. Adjudin exhibits anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation.
||ADL5859 HCl is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel. Phase 2.
||Adomeglivant (LY2409021) is a potent and selective antagonist of glucagon receptor that is used as a chronic treatment for type 2 diabetes.
||ADORA1 Rabbit Recombinant mAb
||ADORA1 Rabbit Recombinant mAb detects endogenous level of total ADORA1.
||ADP (Adenosine diphosphate, adenosine pyrophosphate, Adenosine 5'-diphosphate) is an important organic compound in metabolism and is essential to the flow of energy in living cells.
||Adrafinil (benzhydrylsulfinylacetohydroxamic acid, adrafinyl, CRL-40028) is a mild central nervous system stimulant drug directly affecting CNS function. It is used to relieve excessive sleepiness and inattention in elderly patients.
||Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.
||Adrenosterone (Reichstein's substance G, 11-ketoandrostenedione, 11-oxoandrostenedione) is endogenous steroid hormone that has been promoted as a dietary supplement capable of reducing body fat and increasing muscle mass.
ADX-102 (NS-2) is a free aldehyde trapper potentially useful in the treatment of inflammation, uveitis, and fatty aldehyde dehydrogenase deficiency.
||ADX47273 (BA 94673139) is a potent and specific mGlu5 positive allosteric modulator(PAM) with EC50 of 0.17 μM, showing no activity at other mGlu subtypes.
||ADX88178 is a potent positive allosteric modulator (PAM) of metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.
||AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.
||AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer.
AES-350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition.
||AF-353 (Ro-4) is a potent, selective and orally bioavailable antagonist of P2X3 receptor and P2X2/3 receptor with pIC50 of 8.06, 8.05 and 7.41 for human P2X3, rat P2X3 and human P2X2/3, respectively.
||AF64394 is a selective GPR3 inverse agonist with pIC50 of 7.3.
||Afalanine (N-Acetyl-DL-phenylalanine, Afalanine) acts as an antidepressant and a metabolite.
||Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.
||Afatinib (BIBW2992) Dimaleate
||Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.
||Afloqualone (AFQ, HQ-495) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor.
||Aftin-4 is an Amyloid-β42 (Aβ42) inducer.
||Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.
||AG 1406 is a potent and selective receptor tyrosine kinase VEGF receptor 2 inhibitor.
||AG-494, a member of the tyrphostin family of tyrosine kinase inhibitors, is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 μM) and EGF-dependent cell growth (IC50=6 μM).
||AG-555 (Tyrphostin B46) is an inhibitor of tyrosine kinase, interacts directly with topoisomerase I, thus preventing DNA relaxation. It inhibits EGFR with an IC50 of 0.7 μM.
||AG 556 is an inhibitor of EGFR kinase autophosphorylation over HER1/2 autophosphorylation.
||AG-1024 (Tyrphostin, AGS 200) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, is less potent to IR with IC50 of 57 μM and specifically distinguishes between InsR and IGF-1R (as compared to other tyrphostins).
||AG-120 (racemic), the racemic mixture of AG-120, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity.
||AG126 is a tyrosine kinase inhibitor which selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM.
||AG-13958 (AG-013958), a VEGFR tyrosine kinase inhibitor, is in clinical development with ST administration for treatment of choroidal neovascularization associated with age–related macular degeneration (AMD).
||AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM in a cell-free assay. It is at least 1000-fold more potent than the benzamides.
||AG-1478 (Tyrphostin AG-1478)
||AG-1478 (Tyrphostin AG-1478, NSC 693255) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. AG-1478 (Tyrphostin AG-1478) inhibits encephalomyocarditis virus (EMCV) and hepatitis c virus (HCV) by targeting phosphatidylinositol 4-kinase IIIα (PI4KA).
||AG-1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.
||AG-18 (RG-50810, Tyrphostin A23, TX 825) inhibits EGFR with IC50 of 35 μM.
||AG-490 (Tyrphostin B42)
||AG-490 (Tyrphostin B42, Zinc02557947) is an inhibitor of EGFR with IC50 of 0.1 μM in cell-free assays, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
||AG-636 is an orally available inhibitor of dihydroorotate dehydrogenase (DHODH) with potential antineoplastic activity.
||AG473 is a bioactive compound.
||AG99 (Tyrphostin 46,Tyrphostin A46,Tyrphostin B40) is a potent and selective inhibitor of EGFR.
||Agarotetrol is a chromone derivative found in high concentrations in the water-extract fraction of agarwood. Agarotetrol contributes to the fragrance of agarwood through the generation of LACs upon heating.
||Agerafenib (RXDX-105, CEP-32496) is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret (c-Ret), PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. Phase 1/2.
||AGI-1067 is a novel, phenolic, intra- and extracellular antioxidant that inhibits the expression of a number of proinflammatory genes involved in atherosclerosis.
||AGI-5198 (IDH-C35) is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.
||AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
||Agmatine sulfate is a bioactive metabolite of the arginine amino acid. It has been shown to increase nitric oxide, reduce blood sugar levels and even increase growth hormone levels.
||Agomelatine (S20098) is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor.
||AH7614 (compound 39) is a selective FFA4 (GPR120) antagonist with pIC50s of 7.1 for human FFA4 and 8.1 for mouse FFA4.
||AhR Rabbit Recombinant mAb
||AhR Rabbit Recombinant mAb detects endogenous level of total AhR.
||AI-10-47 is an inhibitor of CBFβ-RUNX binding with IC50 of 3.2 μM.
||AICAR (Acadesine, NSC105823, AICA Riboside), an AMPK activator, results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. AICAR (Acadesine) induces mitophagy. Phase 3.
||Ailanthone (AIL, Δ13-Dehydrochaparrinone), a natural anti-hepatocellular carcinoma (HCC) component in Ailanthus altissima, induces G0/G1-phase cell cycle arrest by decreasing expression of cyclins and CDKs and increases expression of p21 and p27. Ailanthone triggers DNA damage characterized by activation of the ATM/ATR pathway. Ailanthone induces apoptosis which is mitochondrion-mediated and involves the PI3K/AKT signaling pathway in Huh7 cells. Ailanthone is also a potent inhibitor of both full-length Androgen Receptor (AR-FL) and constitutively active truncated AR splice variants (AR-Vs, AR1-651) with IC50 of 69 nM and 309 nM, respectively.
||AIM-100 is a potent small molecule inhibitor of Ack1 with IC50 of 24nM.
||Ajmaline (Cardiorythmine, Tachmalin), found in the root of Rauwolfia serpentina, is a class Ia antiarrhythmic agent.
||Akebia saponin D
||Akebia saponin D (Asperosaponin VI), the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone fractures.
AKI603 is an inhibitor of Aurora kinase A (AurA) with an IC50 of 12.3 nM. AKI603 exhibits strong anti-proliferative activity in leukemic cells.
||Aklomide (2-Chloro-4-nitrobenzamide) is a coccidiostat and used to fight disease, parasites and insects that infest poultry.
||AKOS B018304, an arylalkylidene derivative with polar substitution at para-position, is a potent inhibitor of chikungunya virus with low micro molar activity.
||AKR1C1-IN-1 is a potent and selective inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with Ki of 4 nM, 87 nM, 4.2 μM and 18.2 μM for AKR1C1, AKR1C2, AKR1C3 and AKR1C4, respectively.
||AKT1/2/3 Rabbit Recombinant mAb
AKT1/2/3 Rabbit Recombinant mAb detects endogenous levels of AKT1/2/3.
||Akti-1/2 (Akt Inhibitor VIII) is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3. Akti-1/2 induces apoptosis.
||AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.
||Ala-Gln (l-alanyl-l-glutamine), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals with better solubility and stability than glutamine (Gln).
||Alantolactone (helenin, helenine, Eupatal), a naturally occurring eudesmane-type sesquiterpene lactone (SL), could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction.
||Alas1 Rabbit Recombinant mAb
||Alas1 Rabbit Recombinant mAb detects endogenous level of total Alas1.
||Albendazole (SKF-62979) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
||Albendazole Oxide (Ricobendazole) is a tubulin polymerization or assembly inhibitor, used for the treatment of a variety of parasitic worm infestations.
||Albiglutide fragment is one copy of a 30-amino-acid sequence of modified human GLP-1 (fragment 7-36).
||ALC-0159 is a polyethylene glycol (PEG) lipid conjugate. ALC-0159 allows forming a hydrophilic layer that sterically stabilizes the nanosystem, contributing to storage stability and reducing non-specific binding to proteins.
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization.
||Alcaftadine (Lastacaft, R89674) is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. Alcaftadine is also an antagonist for H2 and H4 receptors with no affinity for the H3 receptor.
||Ald-Ph-amido-PEG4-C2-acid is a non-cleavable linker used for the antibody-drug conjugates (ADCs).
||Ald-Ph-amido-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker for antibody-drug-conjugation (ADC).
||Ald-Ph-NHS ester is an uncleavable linker for antibody-drug-conjugation (ADC).
||ALDH1A1 Rabbit Recombinant mAb
||ALDH1A1 Rabbit Recombinant mAb detects endogenous level of total ALDH1A1.
||Alectinib (CH5424802, AF-802, RG-7853) is a potent ALK inhibitor with IC50 of 1.9 nM in cell-free assays, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429.
||Alectinib (CH5424802) hydrochloride
||Alectinib (AF802, CH5424802, RO5424802, RG-7853) is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.
||Alendronate sodium trihydrate
||Alendronate sodium trihydrate (G-704650, MK-217), a nitrogen-containing bisphosphonate, is a potent inhibitor of bone resorption used for the treatment and prevention of osteoporosis.
||Alendronic acid (alendronate) is a nitrogen-containing, second generation bisphosphonate used for osteoporosis, osteogenesis imperfecta, and several other bone diseases.
||Aleuritic Acid (Aleuritolic acid, 9,10,16-trihydroxy-palmitic acid), a major constituent acid of lac resin (shellac), is isolated from the resin and mainly used in the perfumery industry as a starting material for the preparation of "musk" aroma compounds as well as medicinal and bioactive compounds.
||Alfacalcidol (1-hydroxycholecalciferol) is a non-selective VDR activator medication.
||Alflutinib (AST2818) mesylate
||Alflutinib (AST2818, Furmonertinib) mesylate is a third-generation epidermal growth factor receptor (EGFR) inhibitor that inhibits both EGFR-sensitive mutations and T790M mutations. Alflutinib (AST2818), primarily metabolized by CYP3A4, is also a potent CYP3A4 inducer with EC50 of 0.25 μM.
||Alfuzosin, a quinazoline derivative, is a selective and competitive α1-adrenoceptor antagonist.
||Alfuzosin HCl is an alpha1 receptor antagonist used to treat benign prostatic hyperplasia (BPH).
||Alibendol (EB 1856) is an antispasmodic,choleretic, and cholekinetic.
||Alimemazine (Trimeprazine Tartrate, Methylpromazine Tartrate) is a phenothiazine derivative that is used as an antipruritic.
||Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Alisertib induces cell cycle arrest, apoptosis and autophagy. Phase 3.
||Aliskiren is a renin inhibitor with antihypertensive activity.
||Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.
||Alismoxide is a natural product with anti-inflammatory effects.
||Alisol B, a triterpene from Alismatis rhizoma, induces Bax up-regulation and nuclear translocation, the activation of initiator caspase-8 and caspase-9, and executor caspase-3, suggesting the involvement of both extrinsic and intrinsic apoptosis pathways.
||ALIX Rabbit Recombinant mAb
||ALIX Rabbit Recombinant mAb detects endogenous level of total ALIX.
||Alizapride HCl is a dopamine receptor antagonist used for the theropy of nausea and vomiting.
||Alizarin (Anthraquinonic) strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.
||Alizarin Red S
||Alizarin Red S sodium (Alizarin red S mono sodiumsalt, ARS sodium, C.I. Mordant Red 3, C.I 58005, Alizarin Carmine, Alizarin Red, Alizarin sodium monosulfonate, Alizarin sulfonate sodium, Alizarinsulfonic acid sodium salt, Sodium alizarinsulfonate) is an anthraquinone dye that has been used to evaluate calcium-rich deposits by cells in culture.
||ALK inhibitor 2
||ALK inhibitor 2 is a novel and selective ALK kinase inhibitor.
||ALK2-IN-1 (BLU-782) is a potent and selective inhibitor of Activin receptor-like kinase (ALK2) mutant R206H with binding IC50 of <10 nM.
||Alkaline Phosphatase Rabbit Recombinant mAb
||Alkaline Phosphatase Rabbit Recombinant mAb detects endogenous levels of total alkaline phosphatase.
||Alkaloid Compound Library
||A unique collection of 413 alkaloid compounds used for high throughput screening(HTS) and high content screening(HCS).
||All trans-Retinal (Retinaldehyde, Vitamin A aldehyde, Retinene), a component of the retinoid cycle, is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both RAR and RXR. All trans-retinal ias a potent photosensitizer.
||Allantoin (Glyoxyldiureide, 5-Ureidohydantoin), produced from uric acid, is a major metabolic intermediate in most organisms including animals, plants and bacteria.
||Allicin (Diallyl Thiosulfinate), the main biologically active component of the freshly crushed garlic extracts, possesses various biological activities including antibacterial, antifungal and antiparasitic effects.
||Alliin (S-allyl cysteine sulfoxide, ACSO, 3-(Allylsulphinyl)-L-alanine) is a sulfoxide that is a natural constituent of fresh garlic.
||Allitinib (AST-1306, AST-6) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.
||Allitol (Allodulcitol) is a rare polyol found in nature that is useful not only as a sweetener, but also as the raw material for production of chemical compounds.
||Allocryptopine potently blocks hERG (human ether-a-go-go related gene) current with antiarrhythmic effects. Allocryptopine is a derivative of tetrahydropalmatine extracted from Corydalis decumbens (Thunb.) Pers. Papaveraceae.
||Allopregnanolone, a neurosteroid synthesized from progesterone in brain, acts as a highly potent positive allosteric modulator of the GABAA receptor.
||Allopurinol is a purine analog inhibitor of the enzyme xanthine oxidase, used to treat gout or kidney stones, and to decrease levels of uric acid.
||Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
||Allosecurinine (Phyllochrysine) is a Securinega alkaloid isolated from M.indica and M.discoidea with antifungal activity.
Alloxan Monohydrate is the most popular diabetogenic agents used for assessing the antidiabetic or hypoglycemic capacity of test compounds.
||Alloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.
||Allyl Methyl Sulfide
||Allyl Methyl Sulfide (3-Methylthio-1-propene), a bioactive organosulfur compound found in garlic, is reported to modulate disease states such as cancer and infection.
||Allylestrenol is an orally active progestagen of the 19-nortestosterone series resembling progesterone.
||Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.
||Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca2+-dependent K+ channel by decreasing its open probability with IC50 of 0.22 μM.
||Almonertinib (Aumolertinib, HS-10296, Ameile) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.
||Almorexant HCl (ACT-078573) is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.
||Almotriptan Malate (LAS 31416) is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.
||Alobresib (GS-5829) is a novel BET inhibitor that represents a highly effective therapeutics agent against recurrent/chemotherapy-resistant USC-overexpressing c-Myc. Alobresib (GS-5829) inhibits CLL cell proliferation and induces leukemia cell apoptosis through deregulation of key signaling pathways, such as BLK, AKT, ERK1/2, and MYC. Alobresib (GS-5829) also inhibits NF-κB signaling.
||Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP is a cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Aloe-emodin (NSC 38628, Rhabarberone) is an interferon-inducing agent with IC50 of about 1 μg/mL for JEV and of about 0.33 μg/mL for EV71.
||Aloesin (Aloe resin B) is a kind of herbal extraction form the aloe vera. It is a strong inhibitor of tyrosinase activity and up-regulates cyclin E-dependent kinase activity in vitro.
||Alofanib (RPT835) is a novel selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect with IC50 <10 nM on FGF2-induced phoshphorylation of FRS2a in KATO III cells. It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2 binding.
||Alogliptin is a potent, selective inhibitor of the serine protease dipeptidyl peptidase IV (DPP-4) with IC50 values of 2.63 nM and exhibits greater than 10,000 fold selectivity over the closely related serine proteases DPP-8 and DPP-9.
||Alogliptin (SYR-322) benzoate
||Alogliptin (SYR-322) benzoate is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.
||Aloin (Barbaloin, Barbalin), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.
||Aloin B (Isobarbaloin), one isomer of Aloin, is a physiologically active anthraquinone present in aloe.
||Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
||Alosetron Hydrochloride (GR 68755C, GR 68755X, Lotronex) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist.
||Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin treatment reduced cellular entry of SARS-CoV-2 pseudovirions by 92.3%.
||Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.
||Alpha Actinin 4 Rabbit Recombinant mAb
||Alpha Actinin 4 Rabbit Recombinant mAb detects endogenous level of total Alpha Actinin 4.
||Alpha-arbutin (alpha-Arbutoside, 4-hydroxyphenyl-D-lucopyranoside) is a synthetic and functional active ingredient for skin lightening.
||Alpha (α)-asarone (trans-Asarone) is one of the main pharmacologically active compounds present in Acorus calamus Linn (Acoraceae), Acorus tatarinowii Schott (Acoraceae), and Acorus gramineus Solander. It has anticonvulsant, neuroprotective, anxiolytic and nootropic effects.
||Alpha-Estradiol (α-Estradiol, 17 alpha-Estradiol, Alfatradiol, Epiestradiol, Epiestrol, Alora, 17 α-E2), a natural, non-feminizing stereoisomer, a hormonally almost inactive isomer of physiological 17 beta-estradiol (17 β-E2), is a weak inhibitor of estrogen.
||Alpha-mangostin is the main xanthone purified from mangosteen and has health promoting benefits including anti-bacterial, anti-inflammatory, anti-oxidant, anti-cancer and cardioprotective activities. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM. Alpha-mangostin is also an agonist of human STING.
alpha-MSH TFA (α-MSH TFA, α-MSH Trifluoroacetate, alpha-MSH Trifluoroacetate,α-Melanocyte-stimulating hormone TFA, α-Melanocyte-stimulating hormone Trifluoroacetate) is a 13-amino acid peptide hormone. an endogenous MC4R agonist. alpha-MSH TFA is an endogenous MC3R and MC4R agonist with EC50s of 0.16 nM and 56 nM for hMC3R and hMC4R in Hepa cells, respectively.
||Alpha-Naphthoflavone (7,8-benzoflavone), a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.
||Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity.
||Alprenolol hydrochloride is the hydrochloride salt form of alprenolol, which is an beta adrenergic receptorantagonist and is used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.
||Alprostadil (Prostaglandin-E1, PGE1, Edex, Muse, Liprostin) is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It is a Prostaglandin Analog and Prostaglandin E1 Agonist.
||Alrestatin is an inhibitor of aldose reductase which is involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.
ALS22335 is an antiviral agent.
||Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders.
||Altiratinib (DCC-2701) is a potent single-digit nanomolar inhibitor of TRK, Met (c-Met), TIE2, and VEGFR2 kinases with IC50 vaules of 0.9 nM, 4.6 nM, and 0.8 nM for TRKA, B, and C, respectively. It inhibits Met (c-Met) and Met (c-Met) mutant with IC50 values in the range of 0.3-6 nM.
||Altrenogest (A35957, RU2267) is a progestogen structurally related to veterinary steroid trenbolone.
||Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.
||Aluminium hydroxide (Aluminic), found in nature as the mineral gibbsite, is amphoteric (i.e., it has both basic and acidic properties). It is used to treat symptoms of increased stomach acid, such as heartburn, upset stomach, sour stomach, or acid indigestion; also reduce phosphate levels in people with certain kidney conditions.
||Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases.
||Alverine is a smooth muscle relaxant.
||Alverine citrate (NSC 35459) is a drug used for functional gastrointestinal disorders. Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.
||Alvespimycin (17-DMAG) HCl
||Alvespimycin (17-DMAG, NSC 707545, BMS 826476, KOS 1022) HCl is a potent HSP90 inhibitor with IC50 of 62 nM in a cell-free assay. Phase 2.
||Alvimopan (LY 246736, ADL 8-2698) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors.
||Alvimopan dihydrate (LY246736 dihydrate)
||Alvimopan (LY-246736) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors.
||ALW II-41-27 (compound 7) is a potent inhibitor of Eph receptor tyrosine kinase with Kd of 12 nM for EphA2.
||AM095 is an antagonist of the LPA type 1 receptor with IC50 values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively.
||AM-2394 is a structurally distinct glucokinase activator (GKA) with EC50 of 60 nM for glucokinase (GK).
||AM-92016 hydrochloride is a specific rectifier potassium current (IK) blocker. AM-92016 hydrochloride delays rectifier potassium channel (IK).
||AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
||AM251 block the inhibitory effects of endocannabinoids and synthetic cannabinoid agonists on transmitter release through an action at presynaptic cannabinoid 1 receptors in brain.
||AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ.
||AM966 is a potent, selective, and orally active antagonist of LPA(1) receptor that inhibits lung fibrosis in the mouse bleomycin model.
||Amantadine (1-Adamantanamine, 1-Adamantylamine, 1-Aminoadamantane) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is an M2 inhibitor which blocks the ion channel formed by the M2 protein that spans the viral membrane.
||Amantadine HCl (1-adamantanamine) is used to treat or prevent infections of the respiratory tract caused by a certain virus.
Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. Amarogentin induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. Amarogentin (AG) interacts with the α2 subunit of AMP-activated protein kinase (AMPK) and activates the trimeric kinase with EC50 of 277 pM.
||AMAS is a non-cleavable heterobifunctional crosslinker with an NHS ester and maleimide groups. AMAS allows covalent conjugation of amine- and sulfhydryl-containing molecules.
||Ambrisentan (LU-208075, BSF-208075) is a highly selective antagonist of the endothelin-1 type A receptor, used in the treatment of pulmonary arterial hypertension (PAH).
||Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels.
||AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
||Amcasertib (BBI503), a first-in-class cancer stemness kinase inhibitor, is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.
||Amcenestrant (SAR439859, compound 43d) is an orally available and nonsteroidal selective estrogen receptor degrader (SERD) with potential antineoplastic activity. SAR439859 is a potent estrogen receptor (ER) antagonist with EC50 of 0.2 nM for ERα degradation.
||Amcinonide (Cyclocort, CL-34699) is an inhibitor of nitric oxide (NO) release from activated microglia with IC50 of 3.38 nM.
||AMD3465 is a monomacrocyclic CXCR4 antagonist.
||Amdinocillin (Mecillinam, Coactin, FL 1060) is a β-lactam antibiotic with a broad spectrum of antibacterial activity. Amdinocillin is active alone against many gram-negative organisms.
||Amenamevir (ASP2151) is a potent helicase-primase inhibitor and a novel class of antiviral agent.
||Amentoflavone (Didemethyl Ginkgetin) is a biflavonoid originally isolated from Selaginella with antibacterial, antioxidant, antiviral, antidiabetic, and neuroprotective activities.
||Amezinium is a sympathomimetic used for its vasopressor effects in the treatment of hypotensive states. It is a MAO inhibitor, antagonizes the response to tyramine and blocks neuronal uptake of noradrenaline.
||Amfebutamone (Bupropion) HCl
||Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.
||Amfenac Sodium Monohydrate
||Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively.
||AMG 337 is an oral, small molecule, ATP-competitive, highly selective inhibitor of the Met (c-Met) receptor with an IC50 of 1 nM.
||AMG 487 is an orally active and selective CXC chemokine receptor 3 (CXCR3) antagonist that inhibits the binding of IP-10 (CXCL10) and ITAC (CXCL11) to CXCR3 with IC50 of 8.0 nM and 8.2 nM, respectively.
||AMG-1 (c-Met/RON Dual Kinase Inhibitor, RON-IN-1) is a potent inhibitor of human c-Met and RON with IC50 of 4 nM and 9 nM, respectively.
||AMG 208 is a highly selective dual c-Met and RON inhibitor with IC50 of 9 nM for c-Met.
||AMG-25 is a novel potent and selective c-Kit inhibitor.
||AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8.
||AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.
||AMG-47a is a potent, nonselective inhibitor of Lck kinase with IC50 of 3.4 uM and it also inhibits T cell proliferation. AMG-47a exhibit anti-inflammatory activity (ED50) of 11 mg/kg in the anti-CD3-induced production of interleukin-2 (IL-2) in mice.
||AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM， respectively.
||AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.
||AMG-9810 is potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2 and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling.
||AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.
||AMI-1 (free acid)
||AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.
||Amifostine trihydrate is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
||Amikacin sulfate (BB-K8) binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis.
||Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections.
||Amikacin Sulfate Salt
||Amikacin (BAY 41-6551) sulfate, a semisynthetic analog of kanamycin, is an aminoglycoside antibiotic which is very active against most gram-negative bacteria including gentamicin- and tobramycin-resistant strains.
||Amiloride (MK-870) HCl
||Amiloride (MK-870) is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).
||Amiloride HCl dihydrate
||Amiloride HCl dihydrate is a potent epithelial sodium channel (ENaC) blocker, used in the management of hypertension and congestive heart failure.
||Amiloxate (Amiloxiate, Isoamyl Methoxycinnamate, Isopentyl 4-methoxycinnamate, Isoamyl 4-methoxycinnamate, Isoamyl p-methoxycinnamate, Isopentyl p-methoxycinnamate) is EMA-approved chemical UV-filter used in cosmetics. Amiloxate is a cinnamic acid derivative with anti-inflammatory activity.
||Amino-PEG1-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Amino-PEG2-C2-acid is a cleavable 3-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Amino-PEG2-NH-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Amino-PEG3-C2-acid is a cleavable PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Amino-PEG3-C2-Amine is a PEG-based PROTAC linker can be that is applicable to the synthesis of PROTACs.
||Amino-PEG3-C2-Azido is a PEG-based PROTAC linker that is applicable to the synthesis of the PARP1 degrader iRucaparib-TP3.
||Amino-PEG3-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Amino-PEG4-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. Amino-PEG4-alcohol is a non-cleavable 4-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
||Amino-PEG4-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Amino-PEG4-C2-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Amino-PEG4-CH2COOH is also a non-cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Amino-PEG5-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Amino-PEG6-OH is a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Amino-PEG7-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Amino-PEG8-Boc is a cleavable 8-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Amino-PEG9-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Aminoethyl-SS-ethylalcohol is an Alkyl-Chain-based PROTAC linker can be applied into the synthesis of PROTACs. Aminoethyl-SS-ethylalcohol is also a glutathione cleavable ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Aminoglutethimide (BA-16038, NSC-330915) is an aromatase inhibitor with IC50 of 10 μM.
||Aminoguanidine (Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine) is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone.
||Aminomalonic acid (Aminomalonate, Aminopropanedioic acid) is an amino dicarboxylic acid. It has a role as a human metabolite and a Daphnia magna metabolite.
||Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.
||Aminopterin (4-amino Folic Acid, 4-amino PGA, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, Aminopteroylglutamic acid, APGA, NSC 739), a folic acid antagonist, is a competitive inhibitor of dihydrofolate reductase (DHFR) with Ki of 3.7 pM.
||Aminothiazole can be used as a thyroid inhibitor and it has antibacterial activity.
||Amiodarone (NSC 85442) HCl
||Amiodarone (NSC 85442) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.
||Amiselimod hydrochloride (MT-1303) is a novel modulator of sphingosine 1-phosphate receptor-1 (S1P1). Amiselimod hydrochloride reduces the bradycardia effects associated with fingolimod and other S1P receptor modulators.
||Amisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.
||Amitraz (NSC 324552) is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. It is a non-systemic acaricide and insecticide.
||Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.
||Amitriptyline HCl is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline HCl also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. Amitriptyline is a tricyclic antidepressant (TCA).
||Amlexanox (AA-673, CHX-3673, Amoxanox) is an anti-inflammatory antiallergic immunomodulator and also an inhibitor of the protein kinases TBK1 and IKK-ε.
||Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
||Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
||Amlodipine (Amvaz, UK-48340) maleate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
Ammonium chloride is an inorganic compound and can be used for establishing the rat model of renal calcium oxalate calculus.
||Ammonium ferric citrate
||Ammonium ferric citrate (Ferric ammonium citrate, Ammonium iron(III) citrate, Iron ammonium citrate, FerriSeltz) induces ferroptosis in non-small-cell lung carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity.
||Ammonium Formate is the ammonium salt of formic acid. It is widely used in various organic reactions.
||Ammonium glycyrrhizate (Glycamil, Glycyrram) is an ammonium salt extract isolated from licorice root and is commonly used as a flavoring agent and is also used in fragrances, and skin and hair care products.
||Ammonium Glycyrrhizinate (AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt) is a unique product from Licorice root with a very high sweetness. Ammonium glycyrrhizinate is a direct inhibitor of HMGB1 with anti-inflammatory, anti-tumor, anti-diabetic activities. Ammonium Glycyrrhizinate inhibits growth and cytopathology of several unrelated DNA and RNA viruses. Ammonium Glycyrrhizinate also inhibits both hepatic delta 4-5-reductase and 11 beta-hydroxysteroid dehydrogenase.
||Ammonium lactate (Lac-hydrin) is the ammonium salt of lactic acid with mild anti-bacterial properties.
||AMN082 is a selective, orally active, and brain-penetrant agonist of mGluR7 that directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding with EC50 of 64-290 nM at transfected mammalian cells expressing mGluR7.
||Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria.
||Amodiaquine dihydrochloride dihydrate
||Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.
||Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.
||Amonafide (NSC308847, AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Phase 3.
||Amorolfine HCl is an antifungal reagent.
||Amoxapine (CL 67772) is a tricyclic dibenzoxazepine (an N-aryl piperazine) which acts similarly to several other tricyclic antidepressants, amoxapine inhibits GLYT2a transport activity with IC50 of 92 μM.
||Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms.
||Amoxicillin Sodium (Clavulanate) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.
||Amoxicillin (Amoxil, Amoxipen, Moxaline) is a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity.
||AMPA/kainate antagonist-2 is a non-competitive antagonist of AMPA/kainate.
||Ampalex (CX-516, Ampakine CX 516, BDP-12, SPD 420) is a positive allosteric modulator of AMPA receptor. Ampalex exhibits potential treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
||Amphotericin B (AMB, NSC 527017) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.
||Ampicillin is a beta-lactam antibiotic that is part of the aminopenicillin family.
||Ampicillin Trihydrate (NCI-C56086) is a β-lactam antibiotic, which inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane.
||Ampiroxicam (CP 65703) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
||Amprenavir (VX-478, 141W94, KVX-478) is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.
||Amprolium chloride is a thiamin antagonist, which prevents carbohydrate synthesis by blocking thiamine uptake.
||Amsacrine hydrochloride (m-AMSA, acridinyl anisidide) is the hydrochloride salt form of amsacrine, which is an inhibitor of topoisomerase II with antineoplastic activity.
||Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.
||Amygdalin is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds.
||Amylmetacresol is an antiseptic used to treat infections of the mouth and throat.
||Amyloid beta A4 Rabbit Recombinant mAb
||Amyloid beta A4 Rabbit Recombinant mAb detects endogenous level of total Amyloid beta A4.
||AMZ30 (ML136, CS-2122) is a selective and covalent inhibitor of protein phosphatase methylesterase-1(PME-1) with IC50 of 0.60 μM. AMZ30 reduces the demethylated form of PP2A in living cells.
||AN-2718 is an inhibitor of fungal growth that blocks protein synthesis via the oxaborole tRNA trapping (OBORT) mechanism.
||Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity,
prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.
||Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3.
||Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.
||Anagrelide (BL-4162A) is a drug used for the treatment of essential thrombocytosis.
||Anamorelin (ONO-7643, RC-1291, ST-1291) is an orally active, high-affinity, selective agonist of the ghrelin receptor with an EC50 value of 0.74 nM in the HEK293/GRLN FLIPR assay.
Anandamide (Arachidonoyl Ethanolamide) is an endogenous cannabinoid and TRPV1 receptor agonist with Ki values of 89 nM and 371 nM for CB1 and CB2 receptors respectively.
||Anastrozole (ZD-1033) is a third-generation nonsteroidal selective aromatase inhibitor. It may offer greater selectivity compared with other aromatase inhibitors, being without any intrinsic endocrine effects and with no apparent effect on the synthesis of adrenal steroids.
||Anavex 2-73 HCl
||Anavex 2-73 (Blarcamesine, AVex-73, AE-37), an aminotetrahydrofuran derivative, is a mixed muscarinic and sigma-1/σ1 Receptor agonist with IC50 of 0.86 μM.
||Andarine (GTx-007, S-4) is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, tissue-selective for anabolic organs. Phase 3.
||Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.
||Androsterone (5alpha-Androsterone) is a steroid metabolite derived from sex hormones, which displays weak androgenic properties.
||Anemoside B4 (Pulchinenoside B4, Chinensioside A, Pulchinenoside C, Pulsatilla saponin B4), extracted from the herb of Pulsatilla chinensis (Bge.) Regel, is a potential antiviral constituent and inhibits the secretion of IL-10.
||Anethole trithione is a drug used in the treatment of dry mouth.
||Angelic acid ((Z)-2-Methylbut-2-enoic acid) is a monocarboxylic unsaturated organic acid that is mostly found in the plants of the family Apiaceae.
||Angelic anhydride (2-Methylisocrotonic Anhydride, (Z)-2-Methylbut-2-enoic anhydride) is a synthetic chemical and usually used in content determination assays and pharmacological experiments.
||Angiogenesis Related compound Library
||A unique collection of 407 small molecules used for angiogenesis research targeting Bcr-Abl,BTK,HIF,VEGFR,FGFR,FAK,etc.
||Angiopoietin 1 Rabbit Recombinant mAb
||Angiopoietin 1 Rabbit Recombinant mAb detects endogenous level of total angiopoietin 1.
||Angiotensin (1-7) (Ang-(1-7), Angiotensin fragment 1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. Angiotensin (1-7) is a canine ACE inhibitor with an IC50 of 0.65 μM and inhibits the activity mediated by myostatin through Mas receptor.
||Angiotensin II human Acetate
||Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. It works via binding to specific receptors present on cell membranes.
||Anhydroicaritin (Cycloicaritin), a prenylated flavonoid natural product, is commonly recognized as one of the effective compounds of Epimedii Herba and exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. It is a potent inhibitor of transcription factor SREBPs.
||Anidulafungin (LY303366), an echinocandin derivative, inhibits glucan synthase activity, used as an antifungal drug.
||Aniracetam (RO 13-5057) is a nootropics and neuroprotective drug.
||Anisodamine (6-Hydroxyhyoscyamine) is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).
||Anisole is a flavouring agent that is a precursor to perfumes, insect pheromones, and pharmaceuticals.
||Anisomycin (Flagecidin, Wuningmeisu C) is a bacterial antibiotic isolated from Streptomyces griseolus, which inhibits protein synthesis, and also act as a JNK activator. Anisomycin upregulates autophagy and increases apoptosis.
||Anle138b is a novel oligomer modulator and an aggregation inhibitor, blocking the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn) with good oral bioavailability, blood-brain-barrier penetration and no detectable toxicity. Anle138b shows a new approach for disease-modifying therapy in neurodegenerative diseases such as prion and Parkinson's disease.
||Anlotinib (AL3818) dihydrochloride
||Anlotinib (AL3818) is a highly potent and selective VEGFR2 inhibitor with IC50 less than 1 nM. It has broad-spectrum antitumor potential in clinical trials. Please use saline solution rather than PBS for dilutions. PBS may cause precipitation.
||Annexin A10 Rabbit Recombinant mAb
||Annexin A10 Rabbit Recombinant mAb detects endogenous level of total annexin A10.
||Annexin V Rabbit Recombinant mAb
||Annexin V Rabbit Recombinant mAb detects endogenous level of total Annexin V.
||Ansamitocin P 3'
||Ansamitocin P 3' (Antibiotic C 15003P3', Maytansinol butyrate) is an antibody drug conjugate (ADC) cytotoxin, exhibiting antitumour activity.
||Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)
||Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.
||Anserine (β-alanyl-N-methylhistidine) is a dipeptide containing β-alanine and 1-methylhistidine. It is normally absent from human tissues and body fluids, and its appearance there is an artifact of diet and serum carnosinase deficiency.
||Ansofaxine hydrochloride (LY03005, LPM570065) is a triple reuptake inhibitor that inhibits serotonin, dopamine and norepinephrine reuptake with IC50 of 723 nM, 491 nM and 763 nM, respectively.
Antazoline Phosphate is the phosphate salt of antazoline. Antazoline is a first-generation antihistaminic agent and acts as a histamine H1 receptor antagonist.
||Anthraquinones (Anthradione, anthracenedione, dioxoanthracene) are the main active constituents in herbs often used to relieve constipation.
||Anti-Aging Compound Library
||A unique collection of 2314 anti-aging compounds used for aging related research.
||Anti-alzheimer Disease Compound Library
||A unique collection of 661 small molecules for exploring the mechanism of alzheimer's disease.
||Anti-cancer Compound Library
||A unique collection of 3864 anti-cancer compounds for multiple cancers: Breast Cancer, Leukemia, Lung Cancer, Lymphoma, etc.
||Anti-cancer Compound Library-Ⅱ
||A unique collection of 914 compounds with anticancer activity which has been verified by broad institute,half of the compounds are non-oncology drugs.
||Anti-cancer Metabolism Compound Library
||A unique collection of 320 small molecules for cancer metabolism research.
||Anti-Cardiovascular Disease Compound Library
||A unique collection of 698 anti-cardiovascular disease related compounds used for high throughput screening(HTS) and high content screening(HCS).
||Anti-diabetic Compound Library
||A unique collection of 149 small molecules for exploring the development of diabetes.
||Anti-Flag-tag Mouse Recombinant mAb
anti-Flag-tag Mouse Recombinant mAb detects the level of Flag-tagged target protein.
||The 1D11.16.8 monoclonal antibody reacts with mouse, human, rat, monkey, hamster, canine and bovine TGF-β (transforming growth factor beta) isoforms 1, 2 and 3.The 1D11.16.8 monoclonal antibody is a neutralizing antibody.
||Anti-infection Compound Library
||A unique collection of 1396 anti-infection compounds with biological activity of antibacterial,antifungal,antiviral,etc.
||The 2.4G2 monoclonal antibody reacts specifically with mouse CD16 (FcγRIII) and CD32 (FcγRII). It has also been reported to react non-specifically via its Fc domain to FcγRI. The 2.4G2 antibody is commonly used in flow cytometry staining experiments to prevent non-specific binding of IgG to the FcγIII and FcγII, and possibly FcγI, receptors prior to staining with antigen specific primary antibodies.
||Anti-mouse CD25 (IL-2Rα)-InVivo
||The PC-61.5.3 monoclonal antibody reacts with mouse IL-2Rα also known as CD25, Ly-43, p55, or Tac.The PC-61.5.3 antibody has been shown to inhibit the binding of IL-2 to both the low and high affinity IL-2 receptor forms. Additionally, the PC-61.5.3 antibody is commonly used to deplete CD4+FoxP3+ T regulatory cells in vivo.
||The PV-1 monoclonal antibody reacts with mouse CD28.The PV-1 antibody has been shown to stimulate the proliferation and cytokine production by activated T and NK cells.
||Anti-mouse CD4 antibody reacts with mouse CD4, which is a 55 kDa cell surface type I membrane glycoprotein. CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells.
||Anti-mouse CD8α reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC).
||Anti-mouse CTLA-4 (CD152)-InVivo
||The UC10-4F10-11 monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. The UC10-4F10-11 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.
||Anti-mouse IFNAR-1-InVivo monoclonal antibody (Clone: MAR1-5A3) reacts with mouse IFNAR-1 (IFN alpha/beta receptor subunit 1). Anti-mouse IFNAR-1-InVivo has been shown to inhibit Type I IFN receptor signaling in vitro and in vivo.
||The R4-6A2 monoclonal antibody reacts with mouse IFNγ (interferon gamma) which is a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. The R4-6A2 antibody has been shown to neutralize both natural and recombinant IFNγ.
||Anti-mouse IL-17A-InVivo monoclonal antibody (Clone:17F3) reacts with mouse IL-17A which is a 15-20 kDa cytokine expressed by Th17 cells, γδ T cells, iNKT cells, NK cells, LTi cells, neutrophils, and intestinal Paneth cells. Anti-mouse IL-17A-InVivo has been shown to neutralize IL-17A in vivo.
||The 11B11 monoclonal antibody reacts with mouse IL-4 (interleukin-4) which is a multifunctional 14 kDa cytokine.The 11B11 monoclonal antibody has been shown to neutralize the bioactivity of natural or recombinant IL-4.
||Anti-mouse IL-6-InVivo monoclonal antibody (Clone:MP5-20F3) can reacts with mouse IL-6 (interleukin-6) which is a 21-28 kDa cytokine that is expressed by many cell types, including T lymphocytes, B lymphocytes, monocytes, fibroblasts, and endothelial cells. Anti-mouse IL-6-InVivo has been shown to neutralize the bioactivity of natural or recombinant IL-6.
||The PK136 monoclonal antibody reacts with mouse NK1.1 also known as CD161b/CD161c, KLRB1, NKR-P1A and Ly-55.
||Anti-mouse PD-L1 (B7-H1)-InVivo
||Anti-mouse PD-L1 (B7-H1)-InVivo (Clone:10F.9G2) monoclonal antibody reacts with mouse PD-L1 (also known as B7-H1, CD274). The 10F.9G2 antibody has been shown to block the interaction between PD-L1 and PD-1 and between PD-L1 and B7-1 (CD80).
||Anti-parasitic Compound Library
||A unique collection of 220 anti-parasitic compounds used for high throughput screening(HTS) and high content screening(HCS).
||Antiarol (3,4,5-trimethoxyphenol) is a member of aromatic phenols and exhibits moderate DPPH free radical scavenging activity.
||Antibiotics compound Library
||A unique collection of 479 antibiotics used for anti- research in order to identify drug target and open up new mechanism and ways to treat human disease.
||Antimonyl potassium tartrate trihydrate
||Antimonyl potassium tartrate trihydrate (Tartar emetic) is a powerful emetic, also used in the treatment of schistosomiasis and leishmaniasis.
||Antineoplaston A10 is a naturally occurring substance in the human body that that can be potentially used for the treatment of glioma, lymphoma, astrocytoma and breast cancer. The main ingredient active of antineoplaston A10 (Phenylacetylglutamine, PG) inhibits RAS and promotes apoptosis.
||Antioxidant Compound Library
||A unique collection of 421 compounds used for exploring the relationship between anti-oxidation and some diseases such as aging,cancer,alzheimer's disease,parkinson's disease,diabetes,etc.
||Antipyrine (Phenazone) is an analgesic and antipyretic agent; selective COX-3 inhibitor.
||Antiviral Compound Library
||A unique collection of 700 antiviral compounds used for exploring novel antiviral drug.
||Anwuligan (Macelignan), a natural compound isolated from Myristica fragrans Houtt, has antimicrobial and anticariogenic activity against Streptococcus mutans and other streptococcus species. It also shows antioxidant, free radical scavenging, and neuroprotective activities.
||AOA hemihydrochloride (Aminooxyacetic acid, Carboxymethoxylamine, AOAA, Aminooxyacetate hemihydrochloride) is an inhibitor of aminobutyrate aminotransferase involved in amino acid and polyamine metabolism. AOA hemihydrochloride is also a CBS (cystathionine β-synthase) inhibitor.
||AP20187 (B/B Homodimerizer) is a chemical inducer of dimerization that activates FKBP-Casp8.
||Apabetalone (RVX-208, RVX-000222) is a potent BET bromodomain inhibitor with IC50 of 0.510 μM for BD2 in a cell-free assay, about 170-fold selectivity over BD1. Phase 2.
||APAF1 Rabbit Recombinant mAb
||APAF1 Rabbit Recombinant mAb detects endogenous level of total APAF1.
||Apalutamide (ARN-509) is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM in a cell-free assay, useful for prostate cancer treatment. Phase 3.
||Apatinib (Rivoceranib, YN968D1) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib induces both autophagy and apoptosis.
||Apatinib (YN968D1) mesylate
||Apatinib mesylate (YN968D1, Rivoceranib) is a potent inhibitor of the VEGF signaling pathway with IC50 values of 1 nM, 13 nM, 429 nM and 530 nM for VEGFR-2, Ret (c-Ret), c-Kit and c-Src, respectively. Apatinib mesylate induces both autophagy and apoptosis.
||Apcin (APC inhibitor) is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C) that binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.
Apcin-A is an anaphase-promoting complex (APC) inhibitor that interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V.
||APD-597 (JNJ-38431055) is a potent and selective G protein-coupled receptor 119 (GPR119) agonist with EC50 of 46 nM for hGPR119 and an inhibitor of Cytochrome P450 2C9 (CYP2C9) with IC50 of 5.8 μM. APD-597 (JNJ-38431055) is developed for treating Type 2 diabetes (T2D).
||APD668 (JNJ28630368) is a potent GPR119 agonist with EC50s of 2.7 and 33 nM for human and rat forms, respectively.
Apelin-13 can efficiently antagonize the APJ receptor with EC50 of 0.37 nM and result in suppress the forskolin-stimulated cAMP production.
||Apigenin (LY 080400)
||Apigenin (NSC 83244, LY 080400) is a potent P450 inhibitor for CYP2C9 with Ki of 2 μM.
Apigenin-7-O-glucuronide (Apigenin-7-glucuronide) is the major flavonoid found in milk thistle. Apigenin 7-o-glucuronide inhibits tumor necrosis factor alpha (TNF-α) and total nitrite release in lipopolysaccharide-activated macrophages.
||Apigetrin (Cosmetin, Cosmosioside, Thalictiin, Cosmosin, Apigenin 7-glucoside), a flavonoid found in many plant leaves and seeds, has been known to possess antimutagenic, anti-cancer, antioxidant and anti-inflammatory properties.
||Apilimod (STA-5326) is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod (STA-5326) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod (STA-5326) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.
||Apilimod (STA-5326) mesylate
||Apilimod (STA-5326) mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod mesylate (STA-5326 mesylate) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.
||Apitolisib (GDC-0980, RG7422, GNE 390) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. Apitolisib activates autophagy and apoptosis simultaneously in pancreatic cancer cells. Phase 2.
||Apixaban (BMS 562247-01)
||Apixaban (BMS 562247-01) is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.
||Apocarotenal is a carotenoid found in spinach and citrus fruits and plays a role as a precursor of vitamin A.
||Apocynin (NSC 2146)
||Apocynin (NSC 2146, Acetovanillone, NSC 209524) is a selective NADPH-oxidase inhibitor with IC50 of 10 μM.
||Apoptosis Compound Library
||A unique collection of 1235 small molecules used for apoptosis research targeting Bcl-2,Caspase,p53,TNF-alpha,Mdm2,survivin, etc.
||Apoptozole (Apoptosis Activator VII) is an inhibitor of heat shock protein 70(HSP70) and Hsc70 with dissociation constants Kd of 0.14 μM and 0.21 μM, respectively. It induces caspase-dependent apoptosis.
||Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apostatin-1 inhibits bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 μM.
||Apraclonidine (Iopidine) is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.
||Apraglutide (FE 203799)
Apraglutide (FE 203799) is a potent and highly selective GLP-2 agonist with EC50s of 0.03 nM and 0.07 nM for hGLP-2 Receptor and rGLP-2 Receptor, respectively.
||Apramycin Sulfate (Ai3-29795) is an aminoglycoside antibiotic, which binds to the deep groove of the RNA.
||Apremilast (CC-10004) is a potent and orally active PDE4 and TNF-α inhibitor with IC50 of 74 nM and 77 nM, respectively.
||Aprepitant (MK-0869, L-754030) is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNFα. Aprepitant inhibits HIV infection of human macrophages.
||Apronal (Apronalide, Allylisopropylacetylurea, Allylisopropylacetylcarbamide) is a hypnotic/sedative drug.
||Aprotinin is a small protein serine protease inhibitor (Kd=0.06 pM for bovine β-trypsin), used to reduce perioperative blood loss and transfusion.
||APS6-45 is an orally active tumor-calibrated inhibitor (TCI) that inhibits RAS/MAPK signaling and exhibits antitumor activity.
APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4).
||APY29 is a type I kinase inhibitor of IRE1α that binds to the ATP-binding site on IRE1α and inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM).
||AQX-016A is a potent agonist of SHIP1. AQX-016A inhibits DNFB induced inflammation in a mouse ear edema/cutaneous anaphylaxis model.
||AR-42 (HDAC-42) is an HDAC inhibitor with IC50 of 30 nM. Phase 1.
||AR-A014418 (GSK-3β Inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.
||AR 231453 is a potent, orally-available and selective GPR119 agonist.
||AR7 is a retinoic acid receptor α (RARα) antagonist.
||Arabic gum, derived from exudates of Acacia senegal or Acacia seyal trees, is a complex polysaccharide indigestible to both humans and animals and considered as a safe dietary fiber.
||Arachidic acid (eicosanoic acid, Icosanoic Acid) is a natural saturated fatty acid used for the production of detergents, photographic materials and lubricants.
||Arachidonic acid (Arachidonate) is an unsaturated, essential fatty acid found in animal and human fat as well as in the liver, brain, and glandular organs. It is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
||Araloside A (Chikusetsusaponin IV), a component of Panax japonicus, is an inhibitor of renin with IC50 of 77.4 μM.
||Arbidol HCl (Umifenovir) is a broad-spectrum antiviral compound that blocks viral fusion, used in treatment of influenza and other respiratory viral infections.
||Arbutin (Uva, p-Arbutin, β-Arbutin) is a tyrosinase inhibitor with IC50 of 0.9 mM and 0.7 mM for Monophenolase and Diphenolase, respectively.
||Arctiin (Arctigenin-4-Glucoside, NSC 315527) acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.
||Arecoline is a muscarinic acetylcholine receptor agonist.
||Arenobufagin is a natural bufadienolide from toad venom and induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.
||Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.
||Argatroban (MCI-9038) is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant.
||Argatroban (Argatroban hydrate, Argipidine) is a direct, selective thrombin inhibitor with anticoagulant effects.
||Argireline is an innovative neuropeptide widely applied topically on the skin.
||Argpressin Acetate is a neurohypophysial hormone found in most mammals. It acts as a neurotransmitter at synapses in the brain, increases [Ca2+]i in cultured rat hippocampal neurons.
||Aripiprazole (OPC-14597) is a novel atypical antipsychotic drug that is reported to be a high-affinity 5-HT receptor partial agonist.
||Aristolochic acid A
||Aristolochic acid A (Aristolochic Acid I, Aristolochin, Aristolochine, TR 1736) is a carcinogenic, mutagenic, and nephrotoxic agent extracted from the flowering plant family Aristolochiaceae.Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and nuclear factor-κB (NF-κB) activities.
||ARN-3236 is a potent, orally available and selective inhibitor of salt-inducible kinase 2 (SIK2) with IC50 of <1 nM, 21.63 nM and 6.63 nM for SIK2, SIK1 and SIK3, respectively. ARN-3236 induces apoptosis in cancer cells.
||ARN14974 is a benzoxazolone carboxamide inhibitor of acid ceramidase with IC50 of 79 nM.
||ARN272 is a FAAH-like anandamide transporter (FLAT) inhibitor.
||Aromatase Rabbit Recombinant mAb
||Aromatase Rabbit Recombinant mAb detects endogenous level of total Aromatase.
||ARP 100 (MMP-2 Inhibitor III, Compound 10a) is a potent and selective inhibitor of MMP-2 with an IC50 of 12 nM and displays less inhibitory activity at MMP-9, MMP-3, MMP-1 and MMP-7 with IC50s of 200 nM, 4500 nM, >50,000 nM and >50,000 nM respectively.
||ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
||ARRY-382 is a highly selective, oral inhibitor of the CSF1R with an IC50 of 9 nM.
||ARS-1620 is a potent, orally bioavailable covalent inhibitor of KRASG12C and could achieve rapid and sustained in vivo target occupancy to induce tumor regression.
||ARS-853 is a selective, covalent KRAS(G12C) inhibitor that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation. ARS-853 also induces apoptosis.
||Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.
||Artemether (SM-224, CGP 56696) is an antimalarial for the treatment of resistant strains of falciparum malaria.
||Artemisic acid (Artemisinic acid), an amorphane sesquiterpene isolated from Artemisia annua L., has a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect.
||Artemisinin (Qinghaosu, Artemisinine) is a sesquiterpene endoperoxide which is a potent antimalarial agent.
||Artesunate (WR-256283) is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.
||Articaine (Ultracaine) is a dental local anesthetic which contains an additional ester group that is metabolized by estearases in blood and tissue.
Arundic acid (ONO-2506) is an astrocyte-modulating agent that delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis.
||ARV-110 is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR. ARV-110 completely degrades androgen receptor (AR) in all cell lines tested with DC50 of < 1 nM. ARV-110 can be used for the research of prostate cancer.
||ARV-771 is a potent pan-(bromodomain and extra-terminal)BET degrader, a novel BET-PROTAC(proteolysis-targeting chimera) with Kd of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.
||ARV-825 is a BRD4 Inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 and sustained down-regulation of MYC.
||AS-041164 is a potent inhibitor of PI 3-kinase.
||AS057278 (3-Methylpyrazole-5-carboxylic acid, MPC) is an inhibitor of D-amino acid oxidase (DAAO).
||AS101, a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.
AS1269574 is a potent, orally available GPR119 agonist with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119.
||AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.
||AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form. AS1842856 suppresses autophagy.
AS1949490 is a potent and selective SHIP-2 inhibitor, with an IC50 of 620 nM. AS1949490 activates glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes.
||AS2863619 is a small-molecule cyclin-dependent kinase CDK8/19 inhibitor with IC50 of 0.6099 nM and 4.277 nM, respectively. AS2863619 is a potent Foxp3 inducer in Tconv cells.
||Asapiprant (S-555739) is a potent and selective antagonist for DP1 receptor with Ki of 0.44 nM.
||Asaraldehyde (Asaronaldehyde) is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.
||Asarinin (Sesamin, Fagarol, Pseudocubebin, Episesamin, Eleutheroside B4), isolated as a racemate from the shrub Zanthoxylum alatum, is usually used as a dietary fat-reduction supplement.
||Asciminib (ABL001) is a potent and selective allosteric ABL1 inhibitor with dissociation constant (Kd) of 0.5-0.8 nM and selectivity to the myristoyl pocket of ABL1.
||Ascomycin (FK520, FR 900520, Immunomycin), an FK-506 analog, is a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Phase 3.
||Asenapine maleate (Org 5222) is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.
||ASH2L Rabbit Recombinant mAb
||ASH2L Rabbit Recombinant mAb detects endogenous level of total ASH2L.
||Asiatic acid (Dammarolic acid, Asiantic acid) is the aglycone of asiaticoside isolated from the plant Centella asiatica, commonly used in wound healing.
||Asiaticoside (Ba 2742, BRN0078195, CCRIS8995, NSC166062, Emdecassol,Madecassol), the major active principle of Centella asiatica, prevents ultraviolet A-dependent photoaging by suppressing ultraviolet A-induced reactive oxygen species production. It also decreases DNA binding by MITF.
||Asimadoline (EMD 61753) is a potent κ opioid receptor agonist with IC50 of 5.6 nM and 1.2 nM for guinea pig and human recombinant κ opioid receptor, respectively.
||ASK1 Rabbit Recombinant mAb
||ASK1 Rabbit Recombinant mAb detects endogenous level of total ASK1.
ASK1-IN-1 is a CNS-penetrant inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with IC50 of 138 nM and 21 nM in cell-based assay and biochemical assay, respectively.
ASLAN003 (LAS 186323) is a potent and orally active inhibitor of DHODH (Dihydroorotate dehydrogenase) with IC50 of 35 nM for human DHODH enzyme activity. ASLAN003 impairs protein synthesis and induces the differentiation and apoptosis transcriptional program in acute myeloid leukemia (AML) cells via activation of AP-1 transcription factors.
||ASN03576800 is an inhibitor of the VP40 matrix protein.
ASP2905 is a potent and selective potassium channel Kv12.2 inhibitor.
||ASP-9521 is a selective, orally bioavailable inhibitor of 17beta-hydroxysteroid dehydrogenase type 5 (17β-HSD5).
||ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM. Phase 1.
||ASP4132 is a potent and orally active activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) with EC50 of 0.018 μM. ASP4132 is used as a clinical candidate for the treatment of human cancer.
||ASP5878 is a novel FGFR-selective inhibitor with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L for recombinant FGFR1, 2, 3, and 4, respectively.
||ASP7663 is an orally bioavailable selective activator of transient receptor potential ankyrin 1 (TRPA1). ASP7663 activates human, rat and mouse TRPA1 receptors with EC50 of 510 nM, 540 nM and 500 nM, respectively. ASP7663 acts by stimulating 5-HT release from QGP-1 cells and exhibiting an abdominal analgesic effect in vivo.
||Aspartame (SC-18862) is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages.
||Asperuloside, an iridoid glycoside found in Herba Paederiae, is a component from traditional Chinese herbal medicine and exerts anti-inflammatory effect.
||Aspirin (NSC 27223)
||Aspirin (NSC 27223, Acetylsalicylic acid, ASA) is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Aspirin induces autophagy and stimulates mitophagy.
||AST-487 (NVP-AST487), a N,N'-diphenyl urea,is an ATP competitive inhibitor of Flt3 with ki of 0.12 μM.Besides FLT3, AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM.
||AST5902 is the principal metabolite of alflutinib both in vitro and in vivo, which exerts remarkable antineoplastic activity similar to alflutinib. AST5902 exhibits much weak CYP3A4 induction potential compared to alflutinib.
||Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.
||Astemizole (R 43512) is a histamine H1-receptor antagonist with IC50 of 4.7 nM. Astemizole is also a potent inhibitor of ether à-go-go 1 (Eag1) and Eag-related gene (Erg) potassium channels. Astemizole has antineoplastic and antipruritic effects.
||Astilbin (Isoastilbin, Neoastilbin, Neoisoastilbin, Taxifolin 3-O-rhamnoside), a flavonoid compound isolated from the rhizome of Smilax glabra Roxb, displays anticancer, antioxidative, anti-inflammatory, and immunosuppressive activities.
||Astragalin (kaempferol-3-glucoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside), a flavonoid from leaves of persimmon and green tea seeds, has anti-tumor, anti-inflammatory and anti-oxidant activities.
||Astragaloside IV (AST-IV, AS-IV) is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. It has various effect on the cardiovascular, immune, digestive, and nervous systems. AS-IV suppresses activation of p-Akt, p-mTOR, p-NF-κB and p-Erk1/2.
||AstragalosideⅠ, is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.
||Astrapterocarpan glucoside (Methylnissolin-3-O-glucoside) is a flavonoid extracted from the roots of Astragalus membranaceus with anti-inflammatory effects.
||ASTX-029 is an orally bioavailable inhibitor of the extracellular signal-regulated kinases (ERK) 1 and 2, with potential antineoplastic activity. ASTX-029 inhibits ERK-dependent tumor cell proliferation and survival.
||Asunaprevir (BMS-650032) is an orally bioavailable inhibitor of the hepatitis C virus enzyme serine protease NS3 that is necessary for protein processing required for viral replication.
||AT-001 (Aldose reductase-IN-1) is an aldose reductase inhibitor with IC50 of 28.9 pM.
||AT-007 is an orally active central nervous system (CNS) penetrant inhibitor of Aldose Reductase. AT-007 is used for the treatment of Galactosemia with IC50 of 100 pM.
AT-130, a non-nucleoside inhibitor of HBV. AT-130 inhibits HBV DNA replication in hepatoma cells but had no effect on viral DNA polymerase activity or core protein translation.
||AT-56 is an orally active and selective inhibitor of lipocalin-type prostaglandin (PG) D synthase (L-PGDS) with Ki of 75 μM and IC50 of 95 μM.
||AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively. Phase 1.
||AT7519 is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM. It is less potent to CDK3 and little active to CDK7. AT7519 also inhibits GSK3β with IC50 of 89 nM. AT7519 induces apoptosis. Phase 2.
||AT7519 HCl is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM in cell-free assays. It is less potent to CDK3 and little active to CDK7. Phase 2.
||AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM in cell-free assays, respectively; little activity outside the AGC kinase family.
||AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays; also potent to Aurora A/B, Abl1(T315I). Phase 2.
||Ataciguat, an anthranilic acid derivative, activates the oxidized form of sGC.
||Ataluren (PTC124) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation). Phase 3.
||Atamparib (RBN-2397) is a potent, selective and orally active NAD+ competitive inhibitor PARP7 with IC50 of <3 nM and Kd of <0.001 μM. RBN-2397 has the potential for the research of tumor treatment.
||Atazanavir (Latazanavir, Zrivada, Reyataz, BMS-232632) is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents. Atazanavir is a substrate and inhibitor of cytochrome P450 isozyme 3A (CYP3A4) and an inhibitor and inducer of P-glycoprotein.
||Atazanavir (BMS-232632) Sulfate
||Atazanavir Sulfate (BMS-232632) is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.
||ATB 346, a novel hydrogen sulphide-releasing derivative of naproxen with remarkably reduced toxicity, inhibits COX activity. ATB 346 is an anti-inflammatory agent that induces apoptosis of human melanoma cells.
||Atenolol (Tenormin, Normiten, Blokium) is a selective β1 receptor antagonist with log Kd values of −6.66±0.05, −5.99±0.14, −4.11±0.07 for binding to the human β1-, β2- and β3-adrenoceptors.
||Atezolizumab (anti-PD-L1) is a fully humanized, IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1, but not the interaction of PD-L2 with PD-1. MW : 145 KD.
||ATF1 Rabbit Recombinant mAb
||ATF1 Rabbit Recombinant mAb detects endogenous levels of ATF1.
||ATF2 Rabbit Recombinant mAb
ATF2 Antibody detects endogenous levels of total ATF2.
||ATF4 Rabbit Recombinant mAb
||ATF4 Rabbit Recombinant mAb detects endogenous level of total ATF4.
||Atg4A Rabbit Recombinant mAb
||Atg4A Rabbit Recombinant mAb detects endogenous level of total Atg4A.
||Atg4B Rabbit Recombinant mAb
||Atg4B Rabbit Recombinant mAb detects endogenous level of Atg4B.
||ATG9A Rabbit Recombinant mAb
||ATG9A Rabbit Recombinant mAb detects endogenous level of total ATG9A.
||ATH686 is a potent, selective and second-generation FLT3 Inhibitor.
||ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.
||Atipamezole (MPV-1248, MPV1248, Antisedan) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug.
||Atipamezole (Antisedan, MPV1248) is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride is hydrochloride form of atipamezole.
||ATN-161 (Ac-PHSCN-NH2) is a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.
||Atomoxetine (LY 139603) is a selective norepinephrine (NE) transporter inhibitor with Ki of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.
||Atopaxar (E5555, ER-172594-00) is a potent and orally-active inhibitor of Protease-activated receptor-1 (PAR-1). E5555 inhibited the binding of a high-affinity thrombin receptor-activating peptide ([(3)H]haTRAP) to PAR-1 with IC50 of 0.019μM.
||Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy.
||Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy.
||Atovaquone (Atavaquone) is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.
||ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) is a multifunctional nucleoside triphosphate and an important endogenous signaling molecule in immunity and inflammation.
||ATP citrate lyase Rabbit Recombinant mAb
||ATP citrate lyase Rabbit Recombinant mAb detects endogenous level of total ATP citrate lyase.
||ATP Disodium (Adenosine-Triphosphate disodium, ATP disodium salt, Adenosine 5'-triphosphate) is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate.
||ATP synthase inhibitor 1
||ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F1/FO-ATP synthase complex that inhibits mitochondrial permeability transition pore (mPTP) opening.
||ATP5A1 Rabbit Recombinant mAb
||ATP5A1 Rabbit Recombinant mAb detects endogenous level of total ATP5A1.
||ATPB Rabbit Recombinant mAb
||ATPB Rabbit Recombinant mAb detects endogenous level of total ATPB.
||Atractylenolide II (AT-II, Asterolide, 2-Atractylenolide), a major sesquiterpenoids isolated from the dried Rhizome of Atractylodes macrocephala, shows a wide range of biological and pharmacological activities, for example, against insomnia and anxiety, neuroprotective, platelet activation and anti-cancer effect.
||Atractylodin (Atractydin) is one of the major constituents of the rhizome of Atractylodes lancea and inhibits N-acylethanolamine-hydrolyzing acid amidase (NAAA) activity with an IC50 of 2.81 µM. Atractylodin also inhibits interleukin-6 (IL-6) by blocking NPM-ALK activation and MAPKs.
||Atractyloside potassium salt
||Atractyloside potassium salt (ATR potassium salt), a toxic diterpenoid glycoside isolated from the fruits of Xanthium sibiricum (Cang'erzi), is a powerful and specific inhibitor of mitochondrial ADP/ATP carriers. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart.
||Atracurium Besylate (BW 33A, 51W89) is a neuromuscular blocking agent with ED95 of 0.2 mg/kg.
||Atrazine (Chromozin, Oleogesaprim, Aktikon, Gesaprim) is a selective triazine herbicide. Atrazine is also a potent endocrine disruptor that is active at low, ecologically relevant concentrations.
||Atropine (Atropen, Atnaa, Tropine tropate, DL-Hyoscyamine) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect.
||Atropine Sulfate (Sulfatropinol, Atropette, Tropintran) is the sulfate salt of atropine, which is a natural alkaloid anticholinergic agent and has potent antimuscarinic effects.
||Atropine sulfate monohydrate
||Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery.
Atuliflapon (AZD5718) is an orally active inhibitor of FLAP with an IC50 of 2 nM.
||Atuveciclib (BAY-1143572) is potent and highly selective PTEFb/CDK9 inhibitor with IC50 values of 13 nM for CDK9/CycT and the ratio of IC50 values for CDK2/CDK9 is about 100. Outside the CDK family, It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3α and GSK3β respectively.
||AU1235, an adamantyl urea, is a potent inhibitor of Mycobacterium tuberculosis protein MmpL3.
||Aucubin (Rhinanthin), an iridoid glycoside existing in medicinal plants, has been reported to show an anti-inflammatory activity by suppression of TNF-α production in murine macrophages.
||AUDA (compound 43) is a potent inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 18 nM and 69 nM for the mouse sEH and human sEH, respectively. AUDA has anti-inflammatory activity that reduces the protein expression of MMP-9, IL-1β, TNF-α and TGF-β. AUDA downregulates Smad3 and p38 signaling pathways.
||AUNP-12 (Aur-012, Aurigene-012, Aurigene NP-12), a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.
||Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.
||Auraptene (7-geranyloxycoumarin) is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects. Auraptene inhibits matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8 and chemokine (C-C motif) ligand-5(CCL5).
||Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity. Auristatin E is an MMAE analog and cytotoxin in Antibody-drug conjugates (ADCs). Auristatin E inhibits cell division by blocking the polymerisation of tubulin.
||Aurora A Inhibitor I (TC-S 7010)
||Aurora A Inhibitor I (TC-S 7010) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B. Aurora A Inhibitor I (TC-S 7010) triggers apoptosis through the ROS-mediated UPR signaling pathway.
||Aurora A Rabbit Recombinant mAb
||Aurora A Rabbit Recombinant mAb detects endogenous levels of total Aurora A.
||Aurora B Rabbit Recombinant mAb
||Aurora B Rabbit Recombinant mAb detects endogenous levels of total Aurora B.
||Aurora kinase Inhibitor II
Aurora kinase Inhibitor II is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively.
||Aurora Kinase Inhibitor III
||Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase with an IC50 of 42 nM and has high selectivity for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively).
||Autophagy Compound Library
||A unique collection of 1025 small molecules with autophagy-inducing or autophagy-inhibiting activity.
||Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. The IC50 value for Vps34 is 19 nM in vitro.
||Auxinole is a potent auxin antagonist of TIR1/AFB receptors that binds TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex. Auxinole inhibits auxin-responsive gene expression.
||Avacopan (CCX168) is an orally administered and selective C5a receptor (C5aR) antagonist.
||Avadomide (CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN.
||Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
||Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.
||Avapritinib (BLU-285) is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous Kit (c-Kit) mutation, D816V in Kit (c-Kit) Exon 17 (IC50 = 0.5 nM).
||Avasimibe (CI-1011, PD-148515) inhibits ACAT with IC50 of 3.3 μM, also inhibits human P450 isoenzymes CYP2C9, CYP1A2 and CYP2C19 with IC50 of 2.9 μM, 13.9 μM and 26.5 μM, respectively.
||Avatrombopag is an orally administered, small-molecule thrombopoietin receptor (c-Mpl) agonist which increases platelet number, but not platelet activation.
||Avelumab (anti-PD-L1) (Bavencio, MSB0010718C) is a fully human IgG1 monoclonal antibody that targets the protein programmed death-ligand 1 (PD-L1). Avelumab exhibits potential antibody-dependent cell-mediated cytotoxicity and is used for the treatment of several kinds of carcinoma. MW=143.8 kDa.
||Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic.
||Avexitide (Exendin (9-39)) is a specific and competitive antagonist of glucagon-like peptide-1 (GLP-1) receptor.
||Avibactam (AVE-1330A, NXL104) is a covalent, reversible, non-β-lactam β-lactamase inhibitor with IC50 values of 8, 80, and 38 nM for TEM-1, P99, and KPC-2 β-lactamases, respectively.
||Avitinib (AC0010) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM). It has comparable anti-tumor activity and tolerated toxicity.
||AVN-492 is a novel highly selective 5-HT6R Antagonist with Ki of 91 pM.
||Avobenzone (Butyl methoxydibenzoylmethane, BF2AVB) is an oil soluble ingredient used in sunscreen products to absorb the full spectrum of UVA rays and a dibenzoylmethane derivative.
||AWD 131-138 (Imepitoin, ELB-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy. AWD 131-138 (Imepitoin) is an antiepileptic and antianxietic drug, AWD 131-138 can stimulate different recombinant isoforms of the rat GABA(A) receptor through the benzodiazepine binding site.
||AWZ1066S is a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis with EC50 of 2.5 nM in cell-based assay.
||AX-024 HCl blocks the interaction of the CD3ε PRS with SH3.1(Nck). AX-024 HCl also inhibits IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.
||Axitinib (AG 013736)
||Axitinib (AG 013736) is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively.
AZ 11645373 is a potent and selective human P2X7 antagonist with KB values of 5-7 nM and > 10,000 nM for hP2X7 and rP2X7 respectively.
||AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM, contributes to recruitment of CENP-E (kinesin-related motor protein), less potent to FAK, JNK1, JNK2, and Kit.
||AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM in cell-free assays, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. AZ628 induces apoptosis.
||AZ 960 is a novel ATP competitive JAK2 inhibitor with IC50 and Ki of <3 nM and 0.45 nM, 3-fold selectivity of AZ960 for JAK2 over JAK3. AZ 960 induces apoptosis and growth arrest.
||AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.
||AZ10606120 dihydrochloride (2HCl) is a potent and selective antagonist for P2X7 receptor (P2X7R) with IC50 of ~10 nM. AZ10606120 dihydrochloride exhibits anti-depressant effects and reduces tumour growth.
||AZ304 is a synthetic inhibitor designed to interact with the ATP-binding site of wild type and V600E mutant BRAF with IC50 values of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R at sub 100 nM potencies.
||AZ32 is a specific inhibitor of the ATM kinase that possesses good BBB penetration in mouse with an IC50 value of <0.0062 μM for ATM enzyme. It shows adequate selectivity over ATR and also has high cell permeability.
||AZ3451 is a potent antagonist of protease-activated receptor 2 (PAR2) that binds to a remote allosteric site outside the helical bundle with IC50 of 23 nM.
||AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
||AZ876 is a novel high-affinity Liver X Receptor (LXR) agonist with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively.
||AZ9482 is a potent and selective inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent centrosome declustering activity with EC50 of < 18 nM in HeLa cells.
AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42 that induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion.
||Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Azacitidine induces mitochondrial apoptosis and autophagy.
||Azacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals.
||Azaguanine-8 (NSC-749, SF-337, SK 1150) is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism.
||Azaindole 1 (TC-S 7001)
||Azaindole 1 (TC-S 7001) is a selective Rho-associated protein kinase (ROCK) inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2 in an ATP-competitive manner.
||Azamethiphos is an organophosphate (OP) pesticide used to combat sea lice infestations in farmed salmonids.
||Azaperone (NSC 170976) crosses the blood-brain barrier and binds to both DI and D2 receptors, being an antagonist of Dopamine receptors with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.
||Azasetron HCl (Y-25130) is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.
||Azatadine (SCH10649) is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.
||Azathioprine is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.
||Azathramycin (Azaerythromycin A, Azaerythromycin) is a macrolide antibiotic containing cladinose.
||AZD-26 (AKT-IN-1) is an allosteric inhibitor of AKT with IC50 of 1.042 μM.
||AZD-5153 6-hydroxy-2-naphthoic acid
||AZD-5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD-5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.
AZD6280 is a novel γ-aminobutyric acid A type A(GABAA) receptor modulator with higher in vitro efficacy at the α2,3 subtypes as compared to the α1 and α5 subtypes.
||AZD7325 is a positive allosteric modulator (PAM) of α2,3 subtype-selective GABA receptor with pKi of 9.51 and has less efficacy at the α1 and α5 receptor subtypes. AZD7325 is a moderate CYP1A2 and a potent CYP3A4 inducer in vitro.
||AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. AZD0156 prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells.
||AZD0364 (ATG-017) is a pre-clinical ERK1/2 inhibitor with an IC50 of 0.6 nM for ERK2.
||AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.
||AZD1208 is a potent, and orally available Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively. AZD1208 induces autophagy, cell cycle arrest and apoptosis. Phase 1.
||AZD1390 is a first-in-class orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases.
||AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.
||AZD1981 is a potent, selective CRTh2 (DP2) receptor antagonist with IC50 of 4 nM, showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. Phase 2.
||AZD2098 is a potent and bioavailable CCR4 receptor antagonist with pIC50 of 7.8.
||AZD2461 is a novel PARP inhibitor with low affinity for Pgp than Olaparib. Phase 1.
||AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.
||AZD3229 is a potent, pan-Kit (c-Kit) mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant Kit (c-Kit) driven Ba/F3 cell lines (GI50=1-50 nM), with good margin to KDR-driven effects. It also inhibits PDGFR mutants (Tel-PDGFRα, Tel-PDGFRβ, V561D/D842V).
||AZD3463 is a novel orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency. AZD3463 suppresses cell viability by inducing both cell apoptosis and autophagy.
||AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.
||AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
||AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM, 6-fold selective over MCT2. Phase 1.
||AZD4547 (ABSK 091) is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM in cell-free assays, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3.
||AZD4573 is a potent inhibitor of CDK9 (IC50 of <0.004 μM) with fast-off binding kinetics (t1/2 = 16 min) and high selectivity versus other kinases, including other CDK family kinases.
||AZD5069 is a novel antagonist of CXCR2, which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with pIC50 values of 6.5.
||AZD5305 is a highly selective and potent inhibitor of PARP1 with an IC50 of 3 nM in wild-type A549 lung cancer cells. AZD5305 shows no or minimal growth inhibitory effects in other cells (IC50s >10μM).
||AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM in cell-free assays. It is less potent to CDK5/6 and also inhibits GSK3β. Phase 1.
||AZD5991 is a macrocyclic MCL-1 inhibitor with sub-nanomolar affinity for MCL-1 (Ki = 0.13 nM). The binding affinity of AZD5991 is about 25-fold lower for mouse Mcl-1 vs. human Mcl-1 but only four-fold lower for rat Mcl-1.
||AZD6482 (KIN-193) is a PI3Kβ inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3Kβ than PI3Kδ, PI3Kα and PI3Kγ in cell-free assays. Phase 1.
||AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations(>10 nM), AZD7545 stimulates PDHK4 activity.
||AZD7594 (AZ13189620) is a potent selective nonsteroidal glucocorticoid receptor modulator with IC50 of 0.9 nM.
||AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6 nM in biochemical assay and more than 100-fold selective against 396 other kinases.
||AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.
||AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.
||AZD8186 is a potent and selective inhibitor of PI3Kβ and PI3Kδ with IC50 of 4 nM and 12 nM, respectively. Phase 1.
||AZD8330 (ARRY704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.
||AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM).
||AZD9496 is an oral estrogen receptor inhibitor that blocks the growth of ER-positive and ESR1 mutant breast tumours in preclinical models.
||AZD9833 is an orally available and selective estrogen receptor (ER) antagonist with antineoplastic activity.
AZD9977 is a potent, selective, and orally active mineralocorticoid receptor (MR) modulator.
||Azelaic acid (Nonanedioic acid, Finacea, Azelex, Anchoic acid) is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.
||Azelastine HCl is a potent, second-generation, selective, histamine receptor antagonist, used in the treatment of rhinitis.
||Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule that inhibits the receptor for advanced glycation endproducts (RAGE), which is an immunoglobulin-like cell surface receptor overexpressed in brain tissues of patients with AD.
||Azelnidipine (UR-12592) is a dihydropyridine calcium channel blocker.
Azemiglitazone (MSDC-0602) is a direct mitochondrial pyruvate carrier (MPC) inhibitor that modulates central carbon metabolism in mice and humans.
||Azetidine-2-carboxylic acid (L-Aze) is a toxic and teratogenic non-protein amino acid that is misincorporated into protein in place of proline, altering collagen, keratin, hemoglobin, and protein folding.
||Azide-PEG5-Tos (Azido-PEG5-OTs) is a cleavable 5-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H is applicable to the synthesis of PROTAC BRD4 Degrader-1.
||Azido-PEG2-C2-acid is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG2-C2-amine is a non-cleavable 2-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Azido-PEG2-CH2COOH is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Azido-PEG3-alcohol is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Azido-PEG3-C-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Azido-PEG4-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Azido-PEG4-CH2-Boc is a cleavable 4-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be applied into the synthesis of PROTACs.
||Azido-PEG5-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Azido-PEG5-Boc is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Azido-PEG6-amine is a PEG-based PROTAC linker that can be applied into the synthesis of PROTACs. Azido-PEG6-amine is also a non-cleavable 6-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Azido-PEG7-amine is a non-cleavable 7-unit PEG ADC linker applied into the synthesis of antibody-drug conjugates (ADCs).
||Azido-PEG8-amine is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.
||Azido-PEG9-acid is a non-cleavable 9-unit PEG ADC linker applied in the synthesis of antibody-drug conjugates (ADCs).
||Azilsartan (TAK-536) is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM.
||Azilsartan Medoxomil (TAK-491) is a potent angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM, exhibits >10,000-fold selectivity over AT2.
||Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
||Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.
||Azlocillin sodium salt
||Azlocillin is an acylampicillin with a broad spectrum against bacteria.
||Azo Rubine is an synthetic red food dye and is used for the purposes where food is heat-treated after fermentation.
||Azodicarbonamide is the first known nucleocapsid inhibitor that inhibits HIV-1 and a broad range of retroviruses by targeting the nucleocapsid CCHC domains. Azodicarbonamide inhibits the HIV-1RF-induced cytopathicity of CEM-SS cells with an EC50 of 38 µM in a standard cell-based antiviral assay .
||Azomycin (2-Nitroimidazole) is an antimicrobial antibiotic produced by a strain of Nocardia mesenterica.
||Azoramide is a small-molecule modulator of the unfolded protein response (UPR). It improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress.
||Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection.
||Azumolene (EU4093 free base), an equipotent dantrolene analog, is a ryanodine receptor (RyR) modulator that inhibits the calcium-release.
||β-Alanine (beta-Alanine, 3-Aminopropanoic acid) is a naturally occurring beta amino acid formed in vivo by the degradation of dihydrouracil and carnosine. It acts as a neurotransmitter by activating glycine and GABA receptors.
||β-Alanine methyl ester hydrochloride
||β-Alanine ethyl ester is the ethyl ester of the non-essential amino acid β-alanine.