For research use only.
Catalog No.S3881 Synonyms: Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid
Molecular Weight(MW): 192.17
Scopoletin is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.
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|Description||Scopoletin is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.|
Scopoletin (1-50 μg/ml) inhibits the release of PGE2, TNF-a, IL-1b and IL-6 and suppresses the expression of COX-2 in a concentration-dependent manner. In vitro studies reveal that scopoletin lessens rotenone-induced apoptosis in SH-SY5Y cells through preventing oxidative injury. Particularly, scopoletin markedly up-regulates DJ-1, which then promotes the nuclear translocation of Nrf2 and transactivation of antioxidant genes. Scopoletin prevents the nuclear exportation of Nrf2 by reducing the levels of Keap1 and thereby enhancing the neuronal defence system.
|In vivo||Scopoletin expressively represses the aortic oxido-lipidemic stress and thereby upholding normal morphology of the aorta, and thus minimizing the peril of CVD.|
|In vitro||DMSO||38 mg/mL (197.74 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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