Scopoletin

Synonyms: Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid

Scopoletin (Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid) is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.

Scopoletin Chemical Structure

Scopoletin Chemical Structure

CAS: 92-61-5

Purity & Quality Control

Batch: Purity: 99.99%
99.99

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Biological Activity

Description Scopoletin (Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin, Chrysatropic acid) is the main bioactive constituent of flower buds from Magnolia fargesii with anti-inflammatory, hypouricemic, and antioxidant activities.
In vitro
In vitro Scopoletin (1-50 μg/ml) inhibits the release of PGE2, TNF-a, IL-1b and IL-6 and suppresses the expression of COX-2 in a concentration-dependent manner[1]. In vitro studies reveal that scopoletin lessens rotenone-induced apoptosis in SH-SY5Y cells through preventing oxidative injury. Particularly, scopoletin markedly up-regulates DJ-1, which then promotes the nuclear translocation of Nrf2 and transactivation of antioxidant genes. Scopoletin prevents the nuclear exportation of Nrf2 by reducing the levels of Keap1 and thereby enhancing the neuronal defence system[3].
Cell Research Cell lines RAW 264.7 cell line
Concentrations 1-50 μg/ml
Incubation Time 2 h
Method Cells (1×106/ml) are pre-incubated 2 h with scopoletin (1-50 μg/ml) and further cultured 6 h or 12 h with LPS (100 ngyml) in 24-well plates. Supernatants are removed at the allotted times and PGE2, TNF-a, IL-1b and IL-6 levels are quantified by immunoassay kits.
In Vivo
In vivo Scopoletin expressively represses the aortic oxido-lipidemic stress and thereby upholding normal morphology of the aorta, and thus minimizing the peril of CVD[2].
Animal Research Animal Models Healthy male albino rats of Wistar strain
Dosages 10 mg/kg
Administration oral

Chemical Information & Solubility

Molecular Weight 192.17 Formula

C10H8O4

CAS No. 92-61-5 SDF Download Scopoletin SDF
Smiles COC1=C(C=C2C(=C1)C=CC(=O)O2)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 38 mg/mL ( (197.74 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble


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In vivo
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