Picroside I

Catalog No.S3787 Synonyms: 6'-Cinnamoylcatalpol

For research use only.

Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.

Picroside I Chemical Structure

CAS No. 27409-30-9

Purity & Quality Control

Choose Selective Anti-infection Inhibitors

Biological Activity

Description Picroside I (6'-Cinnamoylcatalpol), an iridoid glycoside, is a hepatoprotective agent which is reported to be antimicrobial and used against hepatitis B.
In vitro

Picrosides I and II cause a concentration-dependent (> 0.1 μM) enhancement of basic fibroblast growth factor (bFGF, 2 ng/ml)-, staurosporine (10 nM)- and dibutyryl cyclic AMP (dbcAMP, 0.3 mM)-induced neurite outgrowth from PC12D cells. Picrosides activate MAP kinase-dependent signaling pathway[2].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: PC12D cells
  • Concentrations: 60 μM
  • Incubation Time: 10 min
  • Method: For Western blot analysis, PC12D cells are plated at a cell density of 1×106 cells/35-mm culture dish, and cultured in the culture medium overnight. Cells are treated with or without picroside I or II 60 μM in the presence or absence of 7S NGF for 10 min. After the cells are washed with ice-cold PBS, they are lysed. Cell lysates are boiled for 5 min and subsequently sonicated for 3 min. Cell lysates are separated by SDS-polyacrylamide gel electrophoresis PAGE and transferred onto polyvinylidene difluoride membranes.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 98 mg/mL
(198.99 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 492.47
Formula

C24H28O11

CAS No. 27409-30-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C(C=C1)C=CC(=O)OCC2C(C(C(C(O2)OC3C4C(C=CO3)C(C5C4(O5)CO)O)O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05081102 Not yet recruiting Drug: FDC of oxycodone 5 mg/ibuprofen 400 mg|Drug: Tylex Pain Eurofarma Laboratorios S.A. February 2023 Phase 3
NCT03271814 Not yet recruiting Biological: LPS|Other: Placebo Schizophrenia University of Maryland Baltimore January 1 2023 Phase 1
NCT04094948 Not yet recruiting Drug: Clenbuterol|Drug: Placebos Pompe Disease (Late-onset) Duke University January 1 2023 Phase 2
NCT05111054 Suspended Other: Resistance Exercise Muscle Damage Durham University January 2023 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Picroside I | Picroside I supplier | purchase Picroside I | Picroside I cost | Picroside I manufacturer | order Picroside I | Picroside I distributor