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Urolithin A Mitophagy activator

Name: Urolithin A
Brand: Selleck Chemicals
SKU: S5312
Availability: InStock
Rating: 5 (10 reviews)

Cat.No.S5312

Urolithin A (3,8-Dihydroxy Urolithin, 2',7-Dihydroxy-3,4-benzocoumarin), a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.

Chemical Structure

Molecular Weight: 228.20

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Quality Control

Batch: Purity: 99.627%

99.627

Related Targets	CXCR Autophagy Nrf2 LRRK2 ULK FKBP Heme Oxygenase cGAS LC3 Cell wall
Other Mitophagy Inhibitors	Mitochonic acid 5 (MA-5) Sulfosuccinimidyl Oleate Sodium (SSO) P62-mediated mitophagy inducer

Solubility

In vitro
Batch:

DMSO : 46 mg/mL (201.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.100mg/ml (4.82mM)
	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.560mg/ml (2.45mM)
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	228.20	Formula	C₁₃H₈O₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	1143-70-0	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	3,8-Dihydroxy Urolithin; 2',7-Dihydroxy-3,4-benzocoumarin			Smiles	C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O

Mechanism of Action

In vitro	Urolithin A inhibits cell proliferation and reduces oxidative stress status in liver cancer.
References	[1] https://pubmed.ncbi.nlm.nih.gov/25910917/ [2] https://pubmed.ncbi.nlm.nih.gov/31420820/

Applications

Methods	Biomarkers	Images	PMID
Western blot	p53 / p21 / TIGAR p-cdc2 / Cyclin B1 / Cyclin D1		30418550

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06274749	Recruiting	Healthy Volunteer	National Institute on Aging (NIA)\|National Institutes of Health Clinical Center (CC)	May 15 2024	Not Applicable
NCT06362018	Recruiting	Healthy Adults	Amazentis SA\|Mprex Healthcare Pvt. Ltd.	May 7 2024	Not Applicable
NCT04783207	Completed	Healthy	Amazentis SA\|Australian Catholic University	April 21 2021	Not Applicable

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