Home DNA Damage/DNA Repair HDAC inhibitor - ACE inhibitor Sinapinic Acid

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Sinapinic Acid HDAC inhibitor

Cat.No.S3981

Sinapinic acid (Sinapic acid) is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) acts as an inhibitor of HDAC, with IC50 of 2.27 mM, and also inhibits ACE-I activity.
Sinapinic Acid HDAC inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 224.21

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Quality Control

Batch: S398101 DMSO]44 mg/mL]false]Ethanol]44 mg/mL]false]Water]Insoluble]false Purity: 99.9%
99.9

Chemical Information, Storage & Stability

Molecular Weight 224.21 Formula

C11H12O5
 

 Storage (From the date of receipt)
CAS No. 530-59-6 Download SDF Storage of Stock Solutions

Synonyms Sinapic acid Smiles COC1=CC(=CC(=C1O)OC)C=CC(=O)O

Solubility

In vitro
Batch:

DMSO : 44 mg/mL (196.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 44 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

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Mechanism of Action

Targets/IC50/Ki
HDAC [3]
ACE1 [4]
In vitro

Sinapic acid is widespread in the plant kingdom (fruits, vegetables, cereal grains, oilseed crops, and some spices and medicinal plants). Sinapic acid shows antioxidant, antimicrobial, anti-inflammatory, anticancer, and anti-anxiety activity. Sinapic acid inhibits nuclear factor-kappa B (NF-κB) activation in macrophages. Via NF-κB inactivation sinapic acid suppresses the expression of proinflammatory mediators such as inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-α, and interleukin-1β. Sinapic acid exerts an inhibitory effect against tumorigenic colon cells, but a low influence on breast cancer cells. It also shows antiproliferative action (ability to prevent, or retard, the spread of malignant cells into surrounding tissue) on the human breast cancer T47D cell line[1].
In vivo

Sinapic acid is an important anxiolytic (anti-anxiety) agent. Its anxiolytic-like effect is mediated by the γ-aminobutyric acid (GABA) neurotransmitter system. Sinapic acid might act like the agonist of a specific GABA receptor. Due to its metal-chelating ability, it has a protective effect against arsenic-induced toxicity in rats as measured by the activities of serum hepatospecific enzymes, together with lipid peroxidative markers[1]. SA inhibits lipopolysaccharide-induced NO, prostaglandin E2, tumor necrosis factor-α and interleukin-1β production in a dose-dependent manner through the suppression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2, and proinflammatory cytokines expressions. In addition, SA exhibits cognitive-ameliorating effects in a CO2- or scopolamine-induced mouse amnesic model. It attenuates Aβ1-42 protein-induced hippocampal neuronal cell death and thus exhibits neuroprotection against Aβ protein-induced neuronal injuries[2].
References

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