For research use only.
Catalog No.S3981 Synonyms: Sinapic acid
CAS No. 530-59-6
Sinapinic acid (Sinapic acid) is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) acts as an inhibitor of HDAC, with IC50 of 2.27 mM, and also inhibits ACE-I activity.
Purity & Quality Control
Choose Selective HDAC Inhibitors
|Description||Sinapinic acid (Sinapic acid) is a small naturally occurring hydroxycinnamic acid which belongs to phenylpropanoid family and commonly used as matrix in MALDI mass spectrometry. Sinapinic acid (Sinapic acid) acts as an inhibitor of HDAC, with IC50 of 2.27 mM, and also inhibits ACE-I activity.|
Sinapic acid is widespread in the plant kingdom (fruits, vegetables, cereal grains, oilseed crops, and some spices and medicinal plants). Sinapic acid shows antioxidant, antimicrobial, anti-inflammatory, anticancer, and anti-anxiety activity. Sinapic acid inhibits nuclear factor-kappa B (NF-κB) activation in macrophages. Via NF-κB inactivation sinapic acid suppresses the expression of proinflammatory mediators such as inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-α, and interleukin-1β. Sinapic acid exerts an inhibitory effect against tumorigenic colon cells, but a low influence on breast cancer cells. It also shows antiproliferative action (ability to prevent, or retard, the spread of malignant cells into surrounding tissue) on the human breast cancer T47D cell line.
Sinapic acid is an important anxiolytic (anti-anxiety) agent. Its anxiolytic-like effect is mediated by the γ-aminobutyric acid (GABA) neurotransmitter system. Sinapic acid might act like the agonist of a specific GABA receptor. Due to its metal-chelating ability, it has a protective effect against arsenic-induced toxicity in rats as measured by the activities of serum hepatospecific enzymes, together with lipid peroxidative markers. SA inhibits lipopolysaccharide-induced NO, prostaglandin E2, tumor necrosis factor-α and interleukin-1β production in a dose-dependent manner through the suppression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2, and proinflammatory cytokines expressions. In addition, SA exhibits cognitive-ameliorating effects in a CO2- or scopolamine-induced mouse amnesic model. It attenuates Aβ1-42 protein-induced hippocampal neuronal cell death and thus exhibits neuroprotection against Aβ protein-induced neuronal injuries.
-  N Nićiforović, et al. Comprehensive Reviews in Food Science and Food Safety. 2013.
-  Lee HE, et al. Pharmacol Biochem Behav. 2012, 103(2):260-6.
-  Thanaset Senawong, et al. BMC Complement Altern Med . 2013 Sep 22;13:232.
|In vitro||DMSO||44 mg/mL (196.24 mM)|
|Ethanol||44 mg/mL (196.24 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.