Home Endocrinology & Hormones Estrogen/progestogen Receptor chemical Tectoridin

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Tectoridin Estrogen/progestogen Receptor chemical

Cat.No.S3818

Tectoridin (Shekanin), an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy.
Tectoridin Estrogen/progestogen Receptor chemical Chemical Structure

Chemical Structure

Molecular Weight: 462.4

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Quality Control

Batch: S381801 DMSO]92 mg/mL]false]]]false]]]false Purity: 99.7%
99.7

Solubility

In vitro
Batch:

DMSO : 92 mg/mL (198.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 462.4 Formula

C22H22O11

 Storage (From the date of receipt)
CAS No. 611-40-5 Download SDF Storage of Stock Solutions

Mechanism of Action

In vitro
Tectoridin is known as a phytoestrogen. This compound exerts its estrogenic effect mainly via the GPR30 and ERK-mediated rapid nongenomic estrogen signaling pathway. It bound poorly to estrogen receptor α. It increased intracelluar cAMP accumulation and rapidly increased the phosphorylation of ERK1/2, but does not induce phosphorylation of ER α at Ser118.
In vivo
Tectoridin shows significant protective effect on hepatic steatosis induced by ethanol through the modulation of PPAR pathway and protection of mitochondrial injury.
References

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