Tectoridin

Name: Tectoridin
Brand: Selleck Chemicals
SKU: S3818

Synonyms: Shekanin

Catalog No.S3818 Purity: 99.7%

Tectoridin (Shekanin), an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy.

Tectoridin Chemical Structure

CAS: 611-40-5

Purity & Quality Control

Batch: S381801 DMSO] 92 mg/mL] false] ] ] false] ] ] false Purity: 99.7%

99.7

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Biological Activity

Description	Tectoridin (Shekanin), an isoflavone isolated from flowers of Pueraria thunbergiana, has several pharmacological effects including anti-cancer, anti-inflammatory, antioxidant, and hepatoprotectivy.

In vitro
In vitro	Tectoridin is known as a phytoestrogen. Tectoridin exerts its estrogenic effect mainly via the GPR30 and ERK-mediated rapid nongenomic estrogen signaling pathway. It bound poorly to estrogen receptor α. Tectoridin increased intracelluar cAMP accumulation and rapidly increased the phosphorylation of ERK1/2, but does not induce phosphorylation of ER α at Ser118^[1].
Cell Research	Cell lines	MCF-7 human breast cancer cells
	Concentrations	0-10 μM
	Incubation Time	96 h
	Method	MCF-7 cells (5 × 10⁵) are seeded on 60 mm dishes with hormone-free experimental medium and incubated for 48 h at 37°C in order to synchronize the cells in the G0/G1 phase. The cells are then treated with experimental medium supplemented with various concentrations (0-10 μM) of genistein, tectorigenin and tectoridin for 96 h. The cell cycle was analyzed.

In Vivo
In vivo	Tectoridin shows significant protective effect on hepatic steatosis induced by ethanol through the modulation of PPAR pathway and protection of mitochondrial injury^[2].
Animal Research	Animal Models	Male C57BL/6 mice
	Dosages	25, 50 and 100 mg/kg
	Administration	intragastrically

References

Chemical Information & Solubility

Molecular Weight	462.4	Formula	C₂₂H₂₂O₁₁
CAS No.	611-40-5	SDF	Download Tectoridin SDF
Smiles	COC1=C(C=C2C(=C1O)C(=O)C(=CO2)C3=CC=C(C=C3)O)OC4C(C(C(C(O4)CO)O)O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 92 mg/mL ( (198.96 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
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