Sphingosine

Catalog No.S2210 Synonyms: 2-amino-4-trans-octadecene-1,3-diol,C18 Sphingosine

For research use only.

Sphingosine (2-amino-4-trans-octadecene-1,3-diol, C18 Sphingosine) is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.

Sphingosine Chemical Structure

CAS No. 123-78-4

Selleck's Sphingosine has been cited by 1 Publication

Purity & Quality Control

Related Other Products

Biological Activity

Description Sphingosine (2-amino-4-trans-octadecene-1,3-diol, C18 Sphingosine) is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.

Protocol (from reference)

Solubility (25°C)

In vitro

Ethanol 60 mg/mL
(200.34 mM)
DMSO 19 mg/mL
(63.44 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 299.49
Formula

C18H37NO2

CAS No. 123-78-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCCCCCCCCCCC=CC(C(CO)N)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04657146 Not yet recruiting Other: Biorepository Glioblastoma Duke University September 1 2021 --
NCT03447964 Completed Other: dosing of sphingolipids Diabetes Mellitus Type 2|Diabetes Mellitus Type 1 Groupe Hospitalier Pitie-Salpetriere April 4 2017 --
NCT02893397 Recruiting Device: Activity Monitor|Behavioral: Exercise Intervention Malignant Bone Neoplasm M.D. Anderson Cancer Center|National Cancer Institute (NCI) August 30 2016 Not Applicable
NCT02826759 Unknown status Other: diabetes Diabetes Mellitus Type 2|Prediabetic State First Affiliated Hospital Xi''an Jiaotong University|Chinese Medical Association July 2016 --

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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