Rotenone (Barbasco)

Catalog No.S2348 Synonyms: Barbasco, Dactinol, Paraderil, Rotenon, Rotocide

For research use only.

Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

Rotenone (Barbasco) Chemical Structure

CAS No. 83-79-4

Selleck's Rotenone (Barbasco) has been cited by 18 publications

Purity & Quality Control

Choose Selective NADPH-oxidase Inhibitors

Biological Activity

Description Rotenone (Barbasco, Dactinol, Paraderil, Rotenon, Rotocide) is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone inhibits NADH/DB oxidoreductase and NADH oxidase with IC50 of 28.8 nM and 5.1 nM, respectively. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 NYH1U45ITnWwY4Tpc44h[XO|YYm= MUnF[oZm[3Rib36gR4RkOiCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHXm[oVkfCCxbjDD[IMzQkOmY{K1R{BqdnSncnHjeIlwdiClb33wcIV5\XNiaX6gdJJme2WwY3Wgc4Yh[2GvcITveIhm[2mwIHL5JGV[TlBiYX7kM49zKFmIUDDW[Y52eyCocnHncYVvfCCkYYPl[EBz\XCxcoTldkBo\W6nIHHzd4F6 NUPDcXZxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[2PFAyPTlpPkG2OlgxOTV7PD;hQi=>
HEK293 NWr5O4luTnWwY4Tpc44h[XO|YYm= NITSeYNG\m[nY4Sgc44hS2SlMjDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHHzd4V{e2WmIHHzJIVn\mWldDDvckBE\GN{OlPkZ|I2SSCrboTldoFkfGmxbjDjc41xdGW6ZYOgbY4heHKnc3XuZ4Uhd2ZiY3HtdJRwfGinY3nuJIJ6KEW\RmCgZY5lN2:{IGnGVEBX\W63czDmdoFodWWwdDDiZZNm\CC{ZYDvdpRmeiCpZX7lJIF{e2G7 MkToQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ4OECxOVkoRjF4NkiwNVU6RC:jPh?=
HEK293 NUPuN4cyTnWwY4Tpc44h[XO|YYm= NGTsN3ZG\m[nY4Sgc44heDV|IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOg[YZn\WO2IH;uJJA2Oy2yNUOgbY51\XKjY4Tpc44h[2:vcHzlfIV{KGmwIIDy[ZNmdmOnIH;mJINidXC2b4To[YNqdiCkeTDFXWZRKGGwZD;vdkB[TlBiVnXueZMh\nKjZ33lcpQh[mG|ZXSgdoVxd3K2ZYKg[4Vv\SCjc4PhfS=> NYDRTGlVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[2PFAyPTlpPkG2OlgxOTV7PD;hQi=>
HEK293 NWqxbFYyTnWwY4Tpc44h[XO|YYm= NFfMPYxKdmirYnn0bY9vKG:oIH;mJIMuUnWwIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5lfWO2aX;uJI9nKHC{b4TlbY4hcW62ZYLhZ5Rqd25iaX6gdJJme2WwY3Wgc4Yh[2GvcITveIhm[2mwIIfpeIghWGmwMTDifUBGYU[SIHLhd4VlKHKncH;yeIVzKGenbnWgZZN{[Xl? MlXIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ4OECxOVkoRjF4NkiwNVU6RC:jPh?=
HEK293 MojNSpVv[3Srb36gZZN{[Xl? NYThXVdCTW[oZXP0JI9vKGOxZnnsbY4yKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMh[XO|ZYPz[YQh[XNiZX\m[YN1KG:wIHPv[oltcW5zOzDMbY1sOiCrboTldoFkfGmxbjDjc41xdGW6ZYOgbY4heHKnc3XuZ4Uhd2ZiY3HtdJRwfGinY3nuJIJ6KEW\RmCgZY5lN2:{IGnGVEBX\W63czDmdoFodWWwdDDiZZNm\CC{ZYDvdpRmeiCpZX7lJIF{e2G7 Ml3LQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ4OECxOVkoRjF4NkiwNVU6RC:jPh?=
MG63 MmLVSpVv[3Srb36gZZN{[Xl? NEjwUXAyKHWP NU\J[ZBSOSCqch?= NGPYZ3pKdmO{ZXHz[UBqdiCuYXP0ZZRmKHC{b3T1Z5Rqd25iaX6gUWc3OyClZXzsd{BifCBzIIXNJIFnfGW{IEGgbJIh[nliRVzJV2E> Mk\SQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyOEi0PFkoRjF5MEi4OFg6RC:jPh?=
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HT1080 M4rlXWZ2dmO2aX;uJIF{e2G7 MUnJcohq[mm2aX;uJI9nKHC{b13NVFkheHKxZIXjeIlwdiCrbjDoeY1idiCKVEGwPFAh[2WubIOgZpkh\2WuYYTpckB7gW2xZ4LhdIh6KGGwYXz5d4l{ M1\rbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUW4NFU1Lz5zN{G1PFA2PDxxYU6=
neural precursor cells MYHGeY5kfGmxbjDhd5NigQ>? M{DKOmlvcGmkaYTpc44hd2ZibnX1do9{eGincnWgdJJwdGmoZYLheIlwdiCxZjDtc5V{\SCwZYXyZYwheHKnY4Xyd49zKGOnbHzzJIJ6KE2WVDDhd5NigQ>? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRzN{[zNUc,OTd2MUe2N|E9N2F-
HepG2 MX\BcpRqfHWvb4KgZZN{[Xl? MWCyOEBpenN? NH7hNI5CdnSrdIXtc5Ih[WO2aY\peJkh[WejaX7zeEBpfW2jbjDI[ZBIOiClZXzsd{Bi\nSncjCyOEBpenNiYomgUXRVKGG|c3H5MEBGTDVyPUG1{txO MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR6MkiyOEc,OTd2OEK4NlQ9N2F-
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T47D M4fNUWZ2dmO2aX;uJIF{e2G7 M1XHV|Q5KGi{cx?= NWHPcmlQWmWmdXP0bY9vKGmwIFHUVEBt\X[nbDDpckBpfW2jbjDUOFdFKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDIVGxENVWYIHHuZYx6e2m| NX7Ud3BSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG4O|UyOTRpPkKxPFc2OTF2PD;hQi=>
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fibroblast cells MV7xTHRUKGG|c3H5 MXrxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDjc451em:uIFjoJJdqdGRidInw[UBncWK{b3LsZZN1KGOnbHzz MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
OHS-50 NGHhZYNyUFSVIHHzd4F6 NW\sOHM2eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhV0iVLUWwJINmdGy| M17kNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
HepG2 M{HXcWN6fG:2b4jpZ4l1gSCjc4PhfS=> NVH6fZVSOjRiaILz NUXvco1sS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUGWyR{KgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0yNjV{zszN NV\XWWt5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C2NVM{OjdpPkOwOlE{OzJ5PD;hQi=>
DLD1 NWK0eI51TnWwY4Tpc44h[XO|YYm= MYDJcohq[mm2aX;uJI9nKG2rdH;jbI9v\HKrYXygc5hq\GG2aY\lJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDEUGQyKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDvfJlo\W5iY3;ud5VueHSrb36gdoF1\SCkeTDz[YFpd3K|ZTDYSoU6PiCjbnHsfZNmeiCkYYPl[EBie3OjeR?= M{P4XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzN{e0OlczLz5|MUe3OFY4OjxxYU6=
Assay
Methods Test Index PMID
Western blot sestrin2 ; p-AMPK / AMPK ; p-mTOR / mTOR / p-S6K1 / S6K1 / p-4EBP1 / 4EBP1 ; p-CaMKII / CaMKII 26031332 25304210 26859572
Immunofluorescence p65 ; activated caspase-1 23977201
Growth inhibition assay Cell viability 27045591

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 394.42
Formula

C23H22O6

CAS No. 83-79-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=C)C1CC2=C(O1)C=CC3=C2OC4COC5=CC(=C(C=C5C4C3=O)OC)OC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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