Home Apoptosis Apoptosis related chemical Bisdemethoxycurcumin (BDMC)

research use only

Bisdemethoxycurcumin (BDMC) Apoptosis related chemical

Cat.No.S3938

Bisdemethoxycurcumin (BDMC), a natural demethoxy derivative of curcumin, possesses several biological activities, such as anti-inflammation and anti-cancer activities.
Bisdemethoxycurcumin (BDMC) Apoptosis related chemical Chemical Structure

Chemical Structure

Molecular Weight: 308.33

Jump to

Quality Control

Batch: Purity: 99.86%
99.86

Solubility

In vitro
Batch:

DMSO : 62 mg/mL (201.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 25 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 308.33 Formula

C19H16O4

 Storage (From the date of receipt)
CAS No. 33171-05-0 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C1=CC(=CC=C1C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O

Mechanism of Action

In vitro
Bisdemethoxycurcumin (BDMC), a demethoxy derivative of curcumin, is a natural substance found in the turmeric root. It inhibits the growth of gastric cancer SGC 7901 cells in a dose‑dependent manner. This compound arrests the cell growth in G1 phase and thus, cells could not reach S phase and complete the cycle.
In vivo
Bisdemethoxycurcumin (BDMC) may promote apoptosis in tumors via mitochondrial modulation. It inhibits tumor growth and caused an increase in body weight of gastric adenoadenocarcinoma xenograft model.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05542394 Completed
Plasma Levels of Different Curcuminoids Preparations
University of Jordan|Nutritional Fundamentals for Health
 September 20 2022 Not Applicable
NCT01982734 Completed
Pharmacokinetics of New Curcumin Formulations|Safety of New Curcumin Formulations
University of Hohenheim|German Federal Ministry of Education and Research
 November 2012 Early Phase 1
NCT01925287 Completed
Pharmacokinetics of Novel Curcumin Formulations|Safety of Novel Curcumin Formulations
University of Hohenheim|German Federal Ministry of Education and Research
 October 2011 Early Phase 1

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.