Bisdemethoxycurcumin (BDMC)

Catalog No.S3938

For research use only.

Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin and possesses several biological activities, such as anti-inflammation and anti-cancer activities.

Bisdemethoxycurcumin (BDMC) Chemical Structure

CAS No. 33171-05-0

Selleck's Bisdemethoxycurcumin (BDMC) has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin and possesses several biological activities, such as anti-inflammation and anti-cancer activities.
In vitro

Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin, which is a natural substance found in the turmeric root. BDMC inhibits the growth of gastric cancer SGC 7901 cells in a dose‑dependent manner. BDMC arrests the cell growth in G1 phase and thus, cells could not reach S phase and complete the cycle[2].

In vivo BDMC may promote apoptosis in tumors via mitochondrial modulation. BDMC inhibits the tumor growth and caused an increase in body weight of gastric adenoadenocarcinoma xenograft model[2].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: The NSCLC cell lines A549, H460 and SPC-A-1
  • Concentrations: 0-100 μM
  • Incubation Time: 72 h
  • Method:

    The cells are grown at 37˚C in a humidified atmosphere of 5% CO2. To evaluate the hypomethylation effect of bisdemethoxycurcumin, DAC is used as positive control. Curcumin, DMC, BDMC and DAC are prepared as stock solutions (20 mM) in dimethyl sulfoxide (DMSO) and diluted in sterile-filtered media before use. Cells (1×105) are seeded into 6-well culture plates. After 24 h of culture, the cells are treated with curcumin, DMC, BDMC (0-100 μM) or DAC (20 μM) for 72 h.

Animal Research:

[2]

  • Animal Models: human gastric adenoadenocarcinoma xenograft model (nude mice)
  • Dosages: 100 mg/kg/day
  • Administration: s.c.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 308.33
Formula

C19H16O4

CAS No. 33171-05-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=CC=C1C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01982734 Completed Dietary Supplement: curcumin Pharmacokinetics of New Curcumin Formulations|Safety of New Curcumin Formulations University of Hohenheim|German Federal Ministry of Education and Research November 2012 Early Phase 1
NCT01925287 Completed Dietary Supplement: curcumin Pharmacokinetics of Novel Curcumin Formulations|Safety of Novel Curcumin Formulations University of Hohenheim|German Federal Ministry of Education and Research October 2011 Early Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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