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Bisdemethoxycurcumin (BDMC) Apoptosis related chemical

Name: Bisdemethoxycurcumin (BDMC)
SKU: S3938
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3938

Bisdemethoxycurcumin (BDMC), a natural demethoxy derivative of curcumin, possesses several biological activities, such as anti-inflammation and anti-cancer activities.

Chemical Structure

Molecular Weight: 308.33

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: Purity: 99.86%

99.86

Related Targets	Ras STAT TNF-alpha Bcl-2 Caspase PD-1/PD-L1 Ferroptosis p53 RIP kinase c-RET MDM2/MDMX Myc IAP OXPHOS PERK FKBP Thymidylate Synthase ABC Transporter Heme Oxygenase PFKFB Pyroptosis PKD Survivin ASK Bcl-6 Nur77 DAPK TRADD TACE Cuproptosis
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Chemical Information, Storage & Stability

Molecular Weight	308.33	Formula	C₁₉H₁₆O₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	33171-05-0	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	C1=CC(=CC=C1C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O

Solubility

In vitro
Batch:

DMSO : 62 mg/mL (201.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 25 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	Bisdemethoxycurcumin (BDMC), a demethoxy derivative of curcumin, is a natural substance found in the turmeric root. It inhibits the growth of gastric cancer SGC 7901 cells in a dose‑dependent manner. This compound arrests the cell growth in G1 phase and thus, cells could not reach S phase and complete the cycle^[2].
In vivo	Bisdemethoxycurcumin (BDMC) may promote apoptosis in tumors via mitochondrial modulation. It inhibits tumor growth and caused an increase in body weight of gastric adenoadenocarcinoma xenograft model^[2].
References	[1] https://pubmed.ncbi.nlm.nih.gov/21484077/ [2] https://pubmed.ncbi.nlm.nih.gov/25435973/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05542394	Completed	Plasma Levels of Different Curcuminoids Preparations	University of Jordan\|Nutritional Fundamentals for Health	September 20 2022	Not Applicable
NCT01982734	Completed	Pharmacokinetics of New Curcumin Formulations\|Safety of New Curcumin Formulations	University of Hohenheim\|German Federal Ministry of Education and Research	November 2012	Early Phase 1
NCT01925287	Completed	Pharmacokinetics of Novel Curcumin Formulations\|Safety of Novel Curcumin Formulations	University of Hohenheim\|German Federal Ministry of Education and Research	October 2011	Early Phase 1

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