3-Methylglutaric acid

Catalog No.S3347 Synonyms: MGA, 3MG acid

For research use only.

3-Methylglutaric acid (MGA, 3MG acid) is a conspicuous C6 dicarboxylic organic acid that can be used as a single solid-state NMR standard compound to perform all calibration steps except for magnet shimming.

3-Methylglutaric acid Chemical Structure

CAS No. 626-51-7

Purity & Quality Control

Related Other Products

Biological Activity

Description

3-Methylglutaric acid (MGA, 3MG acid) is a conspicuous C6 dicarboxylic organic acid that can be used as a single solid-state NMR standard compound to perform all calibration steps except for magnet shimming.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 29 mg/mL
(198.43 mM)
Water 29 mg/mL
(198.43 mM)
Ethanol ''29 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 146.14
Formula

C6H10O4

CAS No. 626-51-7
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04116073 Recruiting Drug: INCMGA00012 (PD-1 antibody) Pancreatic Cancer Non-resectable|Pancreatic Cancer Metastatic Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins|Incyte Corporation April 9 2020 Phase 2
NCT04158726 Active not recruiting Behavioral: modified Geriatric Assessment (mGA) Acute Myeloid Leukemia Carevive Systems Inc. April 26 2019 Not Applicable
NCT03599713 Active not recruiting Drug: Retifanlimab Metastatic Merkel Cell Carcinoma Incyte Corporation February 25 2019 Phase 2
NCT03729596 Recruiting Biological: MGC018|Biological: MGA012 Squamous Cell Carcinoma of Head and Neck|Triple Negative Breast Cancer|Melanoma|Advanced Solid Tumor Adult|Metastatic Castrate Resistant Prostate Cancer|Non Small Cell Lung Cancer MacroGenics November 21 2018 Phase 1|Phase 2
NCT03597295 Active not recruiting Drug: Retifanlimab Squamous Cell Carcinoma of Anal Canal Incyte Corporation October 8 2018 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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