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3-Methylglutaric acid

Name: 3-Methylglutaric acid
Brand: Selleck Chemicals
SKU: S3347
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S3347

3-Methylglutaric acid (MGA, 3MG acid) is a conspicuous C6 dicarboxylic organic acid that can be used as a single solid-state NMR standard compound to perform all calibration steps except for magnet shimming.

Chemical Structure

Molecular Weight: 146.14

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Quality Control

Batch: S334701 DMSO]29 mg/mL]false]Water]29 mg/mL]false]Ethanol]29 mg/mL]false Purity: 99.39%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS
Datasheet

99.39

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Solubility

In vitro
Batch:

DMSO : 29 mg/mL (198.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 29 mg/mL

Ethanol : 29 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	146.14	Formula	C₆H₁₀O₄	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	626-51-7	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	MGA, 3MG acid			Smiles	CC(CC(O)=O)CC(O)=O

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/31730811/ [2] https://pubmed.ncbi.nlm.nih.gov/16887343/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04116073	Recruiting	Pancreatic Cancer Non-resectable\|Pancreatic Cancer Metastatic	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins\|Incyte Corporation\|National Cancer Institute (NCI)	April 9 2020	Phase 2
NCT04158726	Completed	Acute Myeloid Leukemia	Carevive Systems Inc.	April 26 2019	Not Applicable
NCT02923180	Active not recruiting	Prostate Cancer	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins\|MacroGenics	February 14 2017	Phase 2

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