VitaMin U

Catalog No.S4811 Synonyms: Methylmethioninesulfonium Chloride, Cabagin-U, Smethylmethionine

For research use only.

Vitamin U (Methylmethioninesulfonium Chloride, Cabagin-U, Smethylmethionine) is a vitamin found in green vegetables. It is used in the treatment of peptic ulcers, colitis, and gastritis and has an effect on secretory, acid-forming, and enzymatic functions of the intestinal tract.

VitaMin U Chemical Structure

CAS No. 3493-12-7

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Biological Activity

Description Vitamin U (Methylmethioninesulfonium Chloride, Cabagin-U, Smethylmethionine) is a vitamin found in green vegetables. It is used in the treatment of peptic ulcers, colitis, and gastritis and has an effect on secretory, acid-forming, and enzymatic functions of the intestinal tract.
In vitro

Vitamin U inhibits adipocyte differentiation via down-regulation of adipogenic factors and up-regulation of AMPK activity[1]. Vitamin U, also known as S-methyl methionine is found to increase activity of S-adenosyl-L-homocysteine. This decreases the inhibition of S-adenosyl-L-homocystein and stimulates methylation process[2].

In vivo "vitamin U" is recommended for treating oesophagogastric lesions, chronic gastric ulceration, chronic gastritis, ulcerative colitis, diaphragmatic hernias and peptic ulcers. "Vitamin U" is also recommended as a preventive vitamin for the digestive and intestinal systems. It is found that vitamin U can be used as a donor of methyl groups during bacterial DNA methylation in vivo without changing the specificity of DNA methylation. Vitamin U dose-dependently lowers the increased plasma LDL and normalizes the decreased HDL in dietary-induced hyperlipidemic rats[2].

Protocol (from reference)

Cell Research:[1]
  • Cell lines: 3T3-L1 pre-adipocyte cell lines
  • Concentrations: 10, 50, 70, 90, 100 mM
  • Incubation Time: 24 h
  • Method: 3T3-L1 cells are treated with lipopolysaccharide (100 ng), interferon-γ (10 ng) and different concentrations of S-methylmethionine sulfonium chloride (50, 70, 90, 100 mM). After cells are incubated for 24 hr, MTT (5 mg/ml) is added. Then, the supernatant is discarded, dimethyl sulfoxide is added to the cells and formazan is formed via MTT reduction. Cell viability is measured using an ELISA at 570 nm.
  • (Only for Reference)

Solubility (25°C)

In vitro

Water 39 mg/mL
(195.29 mM)
DMSO Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 199.7
Formula

C6H14NO2 .Cl

CAS No. 3493-12-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C[S+](C)CCC(C(=O)O)N.[Cl-]

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