HIF-1 Signaling Pathway Compound Library

Catalog No.L6100

Offered in 96 or 384 well plate format

A unique collection of 447 HIF-1 signaling pathway compounds used for oxygen sensing related research.

Selleck Chemicals compound library contributes and expedites
the investigation of treatments against COVID19

The researchers at the National Institute of Infectious Diseases, in Japan, successfully found anti-COVID19 drugs within 3 months of
screening FDA-approved drug library from Selleck Chemicals. They have already published this article doi: 10.1101/2020.04.14.039925.

Recently the accomplishment of this research, using Selleck Chemicals library, was reported on Japanese television

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Specific Compounds Quantities Plate Map Dry/solid or DMSO solution

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HIF-1 Signaling Pathway Compound Library Contents

Download the HIF-1 Signaling Pathway Compound Library - SDF

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Download the Compound Library Usage Instructions-pdf

Cited by 167 Publications

Cell,2020,181(7):1518-1532.e14

PubMed: 32497502 ( click the link to review the publication )

Cell Metab,2019,7;29(5):1166-1181.e6.

PubMed: 30799286 ( click the link to review the publication )

Nature,2017,546(7659):533-538

PubMed: 28614297 ( click the link to review the publication )

Nat Med,2014,20(8):954-60

PubMed: 24997607 ( click the link to review the publication )

J Am Chem Soc,2021,143(13):4979-4992

PubMed: 33761747 ( click the link to review the publication )

Sci Adv,2021,7(10)eabe7853

PubMed: 33674313 ( click the link to review the publication )

Nat Chem Biol,2021,10.1038/s41589-021-00751-4

PubMed: 33686292 ( click the link to review the publication )

Nat Commun,2021,12(1):1117

PubMed: 33602919 ( click the link to review the publication )

Clin Cancer Res,2021,clincanres.4037.2020

PubMed: 33547197 ( click the link to review the publication )

Proc Natl Acad Sci U S A,2021,118(13)e2009620118

PubMed: 33762304 ( click the link to review the publication )

Cell Rep,2021,35(1):108940

PubMed: 33784499 ( click the link to review the publication )

Cell Rep,2021,35(1):108959

PubMed: 33811811 ( click the link to review the publication )

J Exp Clin Cancer Res,2021,40(1):90

PubMed: 33676554 ( click the link to review the publication )

Cancers (Basel),2021,13(3)576

PubMed: 33540838 ( click the link to review the publication )

Clin Epigenetics,2021,13(1):54

PubMed: 33691794 ( click the link to review the publication )

Cell Death Dis,2021,12(2):183

PubMed: 33589588 ( click the link to review the publication )

Acta Pharm Sin B,2021,11(1):181-202

PubMed: 33532188 ( click the link to review the publication )

Mol Cancer Ther,2021,molcanther.MCT-20-0666-E.2020

PubMed: 33850004 ( click the link to review the publication )

Stem Cell Res Ther,2021,12(1):151

PubMed: 33632328 ( click the link to review the publication )

ACS Infect Dis,2021,10.1021/acsinfecdis.0c00853

PubMed: 33599488 ( click the link to review the publication )

Am J Cancer Res,2021,11(1):215-235

PubMed: 33520370 ( click the link to review the publication )

J Immunol,2021,ji2000969

PubMed: 33568399 ( click the link to review the publication )

Int J Mol Sci,2021,22(4)1750

PubMed: 33578647 ( click the link to review the publication )

Sci Rep,2021,11(1):4390

PubMed: 33623106 ( click the link to review the publication )
J Biol Chem,2021,jbc.RA120.016477

PubMed: 33397709 ( click the link to review the publication )

Methods,2021,S1046-2023(21)00015-3

PubMed: 33453392 ( click the link to review the publication )

J Gastroenterol Hepatol,2021,10.1111/jgh.15490

PubMed: 33721913 ( click the link to review the publication )

Pathogens,2021,10(2)253

PubMed: 33672424 ( click the link to review the publication )

Hum Cell,2021,10.1007/s13577-021-00497-0

PubMed: 33555519 ( click the link to review the publication )

Hum Cell,2021,10.1007/s13577-021-00497-0

PubMed: 33611700 ( click the link to review the publication )

FEBS Open Bio,2021,11(5):1452-1464

PubMed: 33822489 ( click the link to review the publication )

J Toxicol Sci,2021,46(4):167-176

PubMed: 33814510 ( click the link to review the publication )

In Vivo,2021,35(2):761-777

PubMed: 33622869 ( click the link to review the publication )

STAR Protoc,2021,2(1):100345

PubMed: 33665625 ( click the link to review the publication )

AAPS J,2021,23(2):35

PubMed: 33649974 ( click the link to review the publication )

Genes Cancer,2021,12:12-24

PubMed: 33884102 ( click the link to review the publication )

Nat Commun,2020,14;11(1):1792.

PubMed: 32286289 ( click the link to review the publication )

Nucleic Acids Res,2020,48(20):11566-11576

PubMed: 33053158 ( click the link to review the publication )

Cancer Res,2020,15;80(4):832-842.

PubMed: 31888889 ( click the link to review the publication )

Cell Rep,2020,32(1):107845

PubMed: 32640215 ( click the link to review the publication )

EBioMedicine,2020,60:102988

PubMed: 32927276 ( click the link to review the publication )

Stem Cell Reports,2020,14(3):478-492

PubMed: 32084387 ( click the link to review the publication )

Cancer Lett,2020,469:195-206

PubMed: 31672491 ( click the link to review the publication )

Cancers (Basel),2020,12(6)E1418

PubMed: 32486290 ( click the link to review the publication )

Cell Death Dis,2020,2;11(3):158.

PubMed: 32123161 ( click the link to review the publication )

Cell Death Dis,2020,11(9):724

PubMed: 32895373 ( click the link to review the publication )

Signal Transduct Target Ther,2020,4;5:20.

PubMed: 32195002 ( click the link to review the publication )

Mol Ther Oncolytics,2020,30;17:169-179.

PubMed: 32346607 ( click the link to review the publication )
Cell Chem Biol,2020,20;27(2):197-205.e6.

PubMed: 31734178 ( click the link to review the publication )

Cell Chem Biol,2020,16;27(1):94-104.e5.

PubMed: 31902676 ( click the link to review the publication )

Carcinogenesis,2020,41(7):993-1004

PubMed: 31740922 ( click the link to review the publication )

Antimicrob Agents Chemother,2020,4;AAC.02523-19.

PubMed: 32366713 ( click the link to review the publication )

Toxicol Sci,2020,1;174(2):218-240.

PubMed: 32040181 ( click the link to review the publication )

Int J Mol Sci,2020,18;21(8):2825.

PubMed: 32325639 ( click the link to review the publication )

Sci Rep,2020,24;10(1):5318.

PubMed: 32210281 ( click the link to review the publication )

J Biol Chem,2020,27;jbc.RA120.012981.

PubMed: 32461254 ( click the link to review the publication )

Breast Cancer Res Treat,2020,179(2):337-347.

PubMed: 31655920 ( click the link to review the publication )

PLoS One,2020,15(1):e0228189

PubMed: 31999754 ( click the link to review the publication )

PLoS One,2020,15(5):e0233672

PubMed: 32469945 ( click the link to review the publication )

PLoS One,2020,15(5):e0233089

PubMed: 32459810 ( click the link to review the publication )

J Allergy Clin Immunol,2020,21;S0091-6749(20)30259-1.

PubMed: 32088305 ( click the link to review the publication )

bioRxiv,2020,doi:10.1101/2020.05.26.117770

PubMed: No ( click the link to review the publication )

Sarcoma,2020,2020:6312480

PubMed: 32565715 ( click the link to review the publication )

bioRxiv,2020,2020.04.20.051581

PubMed: 32511378 ( click the link to review the publication )

ACS Pharmacol Transl Sci,2020,3(6):1278-1292

PubMed: 33330842 ( click the link to review the publication )

Genome Biol,2019,20(1):253

PubMed: 31771620 ( click the link to review the publication )

Sci Adv,2019,5(6):eaav9784

PubMed: 31249867 ( click the link to review the publication )

Cell Rep,2019,5;26(6):1544-1556.e8.

PubMed: 30726737 ( click the link to review the publication )

Neuropsychopharmacology,2019,10.1038/s41386-018-0266-7

PubMed: 30518933 ( click the link to review the publication )

Drug Discov Today,2019,24(2):390-402

PubMed: 30399443 ( click the link to review the publication )

Cancers (Basel),2019,30;11(2):156.

PubMed: 30704052 ( click the link to review the publication )

Breast Cancer Res,2019,21(1):37

PubMed: 30845991 ( click the link to review the publication )
Anal Chem,2019,91(8):4995-5003

PubMed: 30813716 ( click the link to review the publication )

Cell Chem Biol,2019,21;26(2):235-243.e5.

PubMed: 30527999 ( click the link to review the publication )

Cancer Discov,2019,9(7):910-925

PubMed: 31048320 ( click the link to review the publication )

Neurobiol Aging,2019,76:24-34

PubMed: 30640040 ( click the link to review the publication )

mSphere,2019,4(3)e00047-19

PubMed: 31118297 ( click the link to review the publication )

Cancer Gene Ther,2019,10.1038/s41417-019-0127-5

PubMed: 31383953 ( click the link to review the publication )

Stem Cells Int,2019,2019:3435901

PubMed: 31871467 ( click the link to review the publication )

Biochem J,2019,476(15):2209-2219

PubMed: 31341008 ( click the link to review the publication )

Cancer Manag Res,2019,11:8391-8405

PubMed: 31571995 ( click the link to review the publication )

Breast Cancer Res Treat,2019,10.1007/s10549-019-05504-5

PubMed: 31784862 ( click the link to review the publication )

Acta Pharmacol Sin,2019,10.1038/s41401-019-0246-4

PubMed: 31197246 ( click the link to review the publication )

Cell Signal,2019,67:109508

PubMed: 31866490 ( click the link to review the publication )

Virology,2019,541:41-51

PubMed: 31826845 ( click the link to review the publication )

Molecules,2019,24(20)E3798

PubMed: 31652525 ( click the link to review the publication )

Int J Parasitol Drugs Drug Resist,2019,10:28-37.

PubMed: 31015150 ( click the link to review the publication )

J Med Virol,2019,91(8):1440-1447.

PubMed: 30900754 ( click the link to review the publication )

Bioengineered,2019,10(1):98-107

PubMed: 31023186 ( click the link to review the publication )

Kaohsiung J Med Sci,2019,10.1002/kjm2.12051

PubMed: 30896891 ( click the link to review the publication )

bioRxiv,2019,doi:10.1101/748129

PubMed: no ( click the link to review the publication )

Curr Protoc Chem Biol,2019,11(2):e64

PubMed: 30816629 ( click the link to review the publication )

Cancer Immunol Res,2019,7(9):1523-1534

PubMed: 31266784 ( click the link to review the publication )

Nat Commun,2018,9(1):1655

PubMed: 29695808 ( click the link to review the publication )

Cancer Res,2018,78(15):4344-4359

PubMed: 29844121 ( click the link to review the publication )

Cancer Res,2018,78(20):5731-5740

PubMed: 30135193 ( click the link to review the publication )
Cell Rep,2018,22(5):1185-1199

PubMed: 29386107 ( click the link to review the publication )

Elife,2018,7e35136

PubMed: 29979149 ( click the link to review the publication )

EBioMedicine,2018,28:80-89.

PubMed: 29396295 ( click the link to review the publication )

Cancer Discov,2018,8(4):498-515

PubMed: 29610289 ( click the link to review the publication )

Cancer Sci,2018,109(4):1220-1229

PubMed: 29453896 ( click the link to review the publication )

PLoS Negl Trop Dis,2018,12(3):e0006326

PubMed: 29522528 ( click the link to review the publication )

Antimicrob Agents Chemother,2018,62(12)e01302-18

PubMed: 30224531 ( click the link to review the publication )

Sci Rep,2018,8(1):13106

PubMed: 30166612 ( click the link to review the publication )

Sci Rep,2018,21;8(1):14178.

PubMed: 30242186 ( click the link to review the publication )

Sci Rep,2018,8(1):12046

PubMed: 30104685 ( click the link to review the publication )

J Cell Physiol,2018,233(1):422-433

PubMed: 28294327 ( click the link to review the publication )

Biochem Biophys Res Commun,2018,495(1):1468-1475

PubMed: 29196261 ( click the link to review the publication )

SLAS Discov,2018,23(2):164-173

PubMed: 28985478 ( click the link to review the publication )

Oncotarget,2018,9(57):31018-31031

PubMed: 30123424 ( click the link to review the publication )

Methods Mol Biol,2018,1795:203-221.

PubMed: 29846930 ( click the link to review the publication )

Methods Mol Biol,2018,1765:333-347

PubMed: 29589319 ( click the link to review the publication )

Oncotarget,2018,9(40):26086-26095

PubMed: 29899844 ( click the link to review the publication )

Oncotarget,2018,9(32):22571-22585

PubMed: 29854299 ( click the link to review the publication )

Nat Commun,2017,17;8:16078.

PubMed: 28714472 ( click the link to review the publication )

Proc Natl Acad Sci U S A,2017,114(36):E7554-E7563

PubMed: 28784769 ( click the link to review the publication )

Cell Rep,2017,20(4):999-1015

PubMed: 28746882 ( click the link to review the publication )

Lab Chip,2017,31;17(3):511-520.

PubMed: 28092382 ( click the link to review the publication )

J Med Chem,2017,60(7):2973-2982

PubMed: 28263602 ( click the link to review the publication )

Anal Chem,2017,89(12):6678-6685

PubMed: 28520400 ( click the link to review the publication )
Mol Cancer Ther,2017,16(12):2656-2667

PubMed: 28878027 ( click the link to review the publication )

Antimicrob Agents Chemother,2017,62(1)

PubMed: 29061736 ( click the link to review the publication )

Sci Rep,2017,7(1):14416

PubMed: 29089548 ( click the link to review the publication )

PLoS One,2017,5;12(1):e0169407.

PubMed: 28056055 ( click the link to review the publication )

SLAS Discov,2017,22(5):507-515

PubMed: 28324660 ( click the link to review the publication )

SLAS Discov,2017,22(5):484-493

PubMed: 28346106 ( click the link to review the publication )

SLAS Discov,2017,22(9):1120-1130

PubMed: 28783477 ( click the link to review the publication )

Parasitol Res,2017,116(10):2619-2626.

PubMed: 28776226 ( click the link to review the publication )

Biol Pharm Bull,2017,40(8):1289-1298.

PubMed: 28769010 ( click the link to review the publication )

PhD School in Cell Biology and Development,2017,1-76

PubMed: None ( click the link to review the publication )

Oncotarget,2017,8(43):73745-73756

PubMed: 29088741 ( click the link to review the publication )

Parasit Vectors,2017,10(1):323

PubMed: 28679424 ( click the link to review the publication )

Oncotarget,2017,8(32):53154-53167

PubMed: 28881801 ( click the link to review the publication )

Methods Cell Biol,2017,138:651-679

PubMed: 28129862 ( click the link to review the publication )

Assay Drug Dev Technol,2017,15(5):198-209

PubMed: 28723269 ( click the link to review the publication )

J Invest Dermatol,2016,136(10):2041-2048

PubMed: 27251789 ( click the link to review the publication )

PLoS Genet,2016,12(9):e1006279

PubMed: 27588951 ( click the link to review the publication )

ACS Infect Dis,2016,2(3):180-186

PubMed: 26998514 ( click the link to review the publication )

Pharmacol Res,2016,113(Pt A):216-227

PubMed: 27543462 ( click the link to review the publication )

J Cyst Fibros,2016,15(3):285-94

PubMed: 26694805 ( click the link to review the publication )

Biogerontology,2016,17(5-6):907-920.

PubMed: 27484416 ( click the link to review the publication )

PLoS One,2016,11(6):e0157497

PubMed: 27362433 ( click the link to review the publication )

PLoS One,2016,11(2):e0149848

PubMed: 26919709 ( click the link to review the publication )

Sensors (Basel),2016,16(3)

PubMed: 26999137 ( click the link to review the publication )
Database (Oxford),2016,7;2016:baw041.

PubMed: 27055828 ( click the link to review the publication )

Oncotarget,2016,7(48):79637-79653

PubMed: 27793034 ( click the link to review the publication )

Curr Protoc Toxicol,2016,69:9.10.1-9.10.26

PubMed: 27479365 ( click the link to review the publication )

Genome Biol,2015,19;16(1):127.

PubMed: 26084335 ( click the link to review the publication )

Clin Cancer Res,2015,21(5):1172-82

PubMed: 25549722 ( click the link to review the publication )

Cancer Res,2015,75(24):5341-54

PubMed: 26627007 ( click the link to review the publication )

Biosens Bioelectron,2015,68:699-704

PubMed: 25668591 ( click the link to review the publication )

Cancer Discov,2015,5(2):154-67.

PubMed: 25501949 ( click the link to review the publication )

Mol Cancer Ther,2015,14(5):1213-23

PubMed: 25777964 ( click the link to review the publication )

Cell Cycle,2015,14(1):109-22

PubMed: 25602521 ( click the link to review the publication )

PLoS One,2015,10(2):e0117246

PubMed: 25659151 ( click the link to review the publication )

PLoS One,2015,10(2):e0116688

PubMed: 25710482 ( click the link to review the publication )

PLoS One,2015,10(11):e0142655

PubMed: 26569102 ( click the link to review the publication )

Oncotarget,2015,6(3):1531-43

PubMed: 25605238 ( click the link to review the publication )

Head Neck,2015,37(12):1722-32

PubMed: 24986420 ( click the link to review the publication )

Assay Drug Dev Technol,2015,13(8):456-65

PubMed: 26383544 ( click the link to review the publication )

Oncotarget,2015,6(34):35247-62

PubMed: 26497213 ( click the link to review the publication )

Mol Cancer Res,2014,12(5):703-13

PubMed: 24554781 ( click the link to review the publication )

PLoS One,2014,9(9):e106784

PubMed: 25198282 ( click the link to review the publication )

Oncotarget,2014,5(15):6512-25

PubMed: 25156567 ( click the link to review the publication )

Curr Protoc Chem Biol,2014,4:177-191

PubMed: 26705509 ( click the link to review the publication )

Assay Drug Dev Technol,2014,12(9-10):514-26

PubMed: 25506801 ( click the link to review the publication )

Oncogenesis,2013,2:e69

PubMed: 24018644 ( click the link to review the publication )

Case Studies using Selleck Compound Libraries

Application of GPCR Compound Library in liver cancer (This article was published in Nature (IF=43) and took about 15 months):
Nature.2019;574(7777):268-272
Application of Kinase Inhibitor Library in colorectal cancer (This article was published in Nature Communications (IF=11) and took about 8 months):
Nat Commun. 2019 16;10(1):2197
Application of FDA-approved Drug Library in antivirus (This article was published in Cell Research (IF=17) and took about 13 months):
Cell Res. 2019;29(9):739-753
Application of FDA-approved Drug Library in metabolism (This article was published in Movement Disorders (IF=8) and took about 10 months):
Mov Disord. 2019;34(3):323-334
Application of Epigenetics Compound Library in acute lymphoblastic leukemia (This article was published in Blood (IF=16) and took about 16 months):
Blood. 2019 17;134(16):1323-1336
Application of Inhibitor Library in tumor immunology (This article was published in Cancer Immunol Res (IF=8.6) and took about 12 months):
Cancer Immunol Res.2017;5(9):790-803

Description & Advantages

•A unique collection of 447 HIF-1 signaling pathway compounds for high throughput screening (HTS) and high content screening (HCS)

•Targets HIF,HDAC,PI3K,MAPK,VHL,etc.

•Used for exploring the mechanism of cells' oxygen sensing

•Some compounds have been approved by the FDA

•Structurally diverse, medicinally active, and cell permeable

•Rich documentation with structure, IC50, and customer reviews

•NMR and HPLC validated to ensure high purity

Product Details

Formulation:	427 compounds pre-dissolved in 10mM DMSO, 8 compounds pre-dissolved in 10mM water and 12 compounds pre-dissolved in 2mM DMSO
Container:	96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Stability:	12 months -20°C in DMSO
Stability:	24 months -80°C in DMSO
Shipping:	Blue ice or dry ice

HIF-1 Signaling Pathway Compound Library Composition

HTS Facility Partners

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A unique collection of 462 validated highly selective inhibitors with covering over 123 targets.
Histone modification compound library

A unique collection of 245 small molecule compounds with biological activity used for histone modification research and associated assays.
HTS Library for Drug Discovery

A unique collection of 99040 compounds features numerous structurally diverse compounds and several alternate compositions.
Human Hormone Related Compound Library

A unique collection of 479 human hormone related compounds used for high throughput screening(HTS) and high content screening(HCS).
Immunology/Inflammation Compound Library

A unique collection of 2792 small molecules with biological activity used for Immunology/Inflammation research and associated assays.
Inhibitor Library

A unique collection of 4174 inhibitors for high throughput screening (HTS) and high content screening (HCS).
Ion Channel Ligand Library

A unique collection of 231 small molecule modulators used for Ion channel research.
JAK/STAT compound library

A unique collection of 184 small molecules used for research in JAK-STAT signaling pathway.
Lipid Metabolism Compound Library

A unique collection of 427 lipid metabolism related compounds used for high throughput screening(HTS) and high content screening(HCS).
Macrocyclic Compound Library

A unique collection of 188 macrocyclic compounds used for high throughput screening(HTS) and high content screening(HCS).
MAPK Inhibitor Library

A unique collection of 259 small molecule inhibitors used for MAPK signaling research.
Medicine Food Homology Compound Library

A unique collection of 470 medicine food homology compounds used for high throughput screening (HTS) and high content screening (HCS).
Metabolism Compound Library

A unique collection of 2893 small molecules with biological activity in numerous metabolic pathway: glycometabolism, lipid metabolism, proteolysis, etc.
Methylation Compound Library

A unique collection of 112 compounds used for researching the function of methylation in epigenetics,cancer,embryogenesis,etc.
Mouse Metabolite Compound Library

A unique collection of 137 mouse metabolites used for high throughput screening(HTS) and high content screening(HCS).
Natural Organic Compound Library

A unique collection of 1126 plant-derived natural organic compounds used for high throughput screening(HTS) and high content screening(HCS).
Neuronal Signaling Compound Library

A unique collection of 1381 small molecule compounds with biological activity used for neurologic research and associated assays
NF-κB Signaling Compound Library

A unique collection of 429 small molecules used for NF-κB signaling pathway research which plays a key role in immunology/inflammation and cancer.
Nucleoside Analogue Library

A unique collection of 188 nucleoside analogues used for high throughput screening(HTS) and high content screening(HCS).
Obesity Compound Library

A unique collection of 936 compounds used for research in obesity.
Phenotypic Screening Library

A unique collection of 3751 bioactive compounds with identified targets used for phenotypic Screening.
PI3K/Akt Inhibitor Library

A unique collection of 350 small molecule inhibitors used for PI3K/Akt/mTOR pathway research.
Protease Inhibitor Library

A unique collection of 384 small molecule inhibitors used for chemical genomics, high-throughput screening (HTS), and high content screening (HCS).
Protein-protein Interaction Inhibitor Library

A unique collection of 188 protein-protein Interaction(PPI) Inhibitors used for high throughput screening(HTS) and high content screening(HCS).
Pyroptosis Compound Library

A unique collection of 771 pyroptosis related compounds used for high throughput screening(HTS) and high content screening(HCS).
Small Molecule Immuno-Oncology Compound Library

A unique collection of 230 Immuno-Oncology small molecules used for oncotherapy in conjunction with other drugs.
Stem Cell Differentation Compound Library

A unique collection of 250 stem cell differentation related compounds used for high throughput screening(HTS) and high content screening(HCS).
Stem Cell Signaling Compound Library

A unique collection of 814 compounds with biological activity used for stem cell regulatory and signaling pathway research.
TGF-beta/Smad compound library

A unique collection of 135 small molecules with biological activity used for TGF-beta/Smad pathway research.
Traditional Chinese Medicine Library

A unique collection of 1289 traditional chinese medicine(TCM) monomer compounds used for high throughput screening(HTS) and high content screening(HCS).
Tyrosine Kinase Inhibitor Library

A unique collection of 533 tyrosine kinase inhibitors for high throughput screening (HTS) and high content screening (HCS).
Ubiquitination Compound Library

A unique collection of 198 small molecules for Ubiquitination related research.

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