Home Immunology & Inflammation Nrf2 activator - Sirtuin activator - Apoptosis related activator - Lipoxygenase inhibitor - COX inhibitor - IκB/IKK inhibitor - DNA/RNA Synthesis inhibitor cis-Resveratrol For research use only.

cis-Resveratrol

Synonyms: cis-RESV, cRes, (Z)-Resveratrol

cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.

cis-Resveratrol Chemical Structure

cis-Resveratrol Chemical Structure

CAS: 61434-67-1

Selleck's cis-Resveratrol has been cited by 1 publication

Purity & Quality Control

Batch: S316801 DMSO] 46 mg/mL] false] Ethanol] 46 mg/mL] false] Water] Insoluble] false Purity: 98.45%
98.45

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Biological Activity

Description cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.
Targets
PXR [1] Nrf2 [2] SIRT1 [2] COX [3]
(Cell-free assay)		 IKKβ [3]
(Cell-free assay)		 Click to View More Targets
1 μM 1 μM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05343741 Recruiting
Psychological Distress
Universidad de las Americas - Quito
 October 17 2022 --
NCT04886635 Recruiting
Cancer of Esophagus
Bas P. L. Wijnhoven|Erasmus Medical Center
 March 9 2021 --
NCT04206943 Unknown status
Acute Lymphoblastic Leukemia|Non Hodgkin Lymphoma
Acibadem University|Acıbadem Atunizade Hospital|The Scientific and Technological Research Council of Turkey|Acıbadem Labcell
 October 12 2019 Phase 1|Phase 2

Chemical Information & Solubility

Molecular Weight 228.24 Formula

C14H12O3
CAS No. 61434-67-1 SDF --
Smiles OC1=CC=C(C=C1)\C=C/C2=CC(=CC(=C2)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 46 mg/mL ( (201.54 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 46 mg/mL

Water : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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