cis-Resveratrol

Catalog No.S3168 Synonyms: cis-RESV, cRes, (Z)-Resveratrol

For research use only.

cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.

cis-Resveratrol Chemical Structure

CAS No. 61434-67-1

Purity & Quality Control

Choose Selective Nrf2 Inhibitors

Biological Activity

Description cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.
Targets
PXR [1] Nrf2 [2] SIRT1 [2] COX [3]
(Cell-free assay)
IKKβ [3]
(Cell-free assay)
Click to View More Targets
1 μM 1 μM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 228.24
Formula

C14H12O3

CAS No. 61434-67-1
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05343741 Not yet recruiting Other: Psychological Intervention Psychological Distress Universidad de las Americas - Quito September 2022 --
NCT04886635 Recruiting Other: Active surveillance Cancer of Esophagus Bas P. L. Wijnhoven|Erasmus Medical Center March 9 2021 --
NCT04206943 Unknown status Biological: Car-T Cell Therapy Acute Lymphoblastic Leukemia|Non Hodgkin Lymphoma Acibadem University|Acıbadem Atunizade Hospital|The Scientific and Technological Research Council of Turkey|Acıbadem Labcell October 12 2019 Phase 1|Phase 2
NCT03994913 Recruiting Biological: CAR-CD19 T Cells Refractory B-Cell Non-Hodgkin Lymphoma|Relapsed B-cell Non-Hodgkin Lymphoma CARsgen Therapeutics Co. Ltd.|First Affiliated Hospital of Zhejiang University|RenJi Hospital August 14 2019 Phase 1|Phase 2
NCT04117516 Completed Procedure: Open surgery|Procedure: Percutaneous surgery Carpal Tunnel Syndrome Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana June 5 2019 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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