Amarogentin

For research use only.

Catalog No.S1273 Synonyms: AG

Amarogentin Chemical Structure

CAS No. 21018-84-8

Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. Amarogentin induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. Amarogentin (AG) interacts with the α2 subunit of AMP-activated protein kinase (AMPK) and activates the trimeric kinase with EC50 of 277 pM.

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Biological Activity

Description

Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. Amarogentin induces apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. Amarogentin (AG) interacts with the α2 subunit of AMP-activated protein kinase (AMPK) and activates the trimeric kinase with EC50 of 277 pM.

Targets
TAS2R1 [2]
()
TNF-α [2]
()
AMPK [4]
()

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (170.49 mM)
Water Insoluble
Ethanol '''50 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 586.54
Formula

C29H30O13

CAS No. 21018-84-8
Storage powder
in solvent
Synonyms AG

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04571502 Not yet recruiting Other: CareHeroes Neurocognitive Disorders|Alzheimer Disease|Caregiver Florida International University|National Institute on Aging (NIA)|University of Alabama Tuscaloosa September 2023 Not Applicable
NCT03047239 Not yet recruiting Device: SENSIMED Triggerfish Open Angle Glaucoma Sensimed AG October 2022 Not Applicable
NCT04811833 Not yet recruiting -- Gastrointestinal Stromal Tumors|Gastrointestinal Neoplasms|Digestive System Neoplasm|Stomach Tumor|Small Intestine Tumor|Colon Tumor|Rectum Tumor Aesculap AG|B.Braun Surgical SA March 2022 --
NCT04536090 Not yet recruiting Drug: Isoquercetin (IQC-950AN) COVID-19 Institut de Recherches Cliniques de Montreal|Pharmascience Inc.|SCiAN Services Inc.|Quercis Pharma AG January 2022 Phase 2
NCT05031780 Not yet recruiting Drug: Mitapivat|Other: Mitapivat-matching placebo Sickle Cell Disease Agios Pharmaceuticals Inc. December 2021 Phase 2|Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID