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Tangeretin Antioxidant chemical

Name: Tangeretin
Brand: Selleck Chemicals
SKU: S2363
Availability: InStock
Rating: 5 (6 reviews)

Cat.No.S2363

Tangeretin (Tangeritin), a natural polymethoxylated flavone concentrated in the peel of citrus fruits, an inhibitor of Notch1, is known to have antiproliferative, antiinvasive, antimetastatic and antioxidant activities.

Chemical Structure

Molecular Weight: 372.37

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Quality Control

Batch: Purity: 99.85%

99.85

Related Targets	Bcl-2 Caspase PD-1/PD-L1 Ferroptosis p53 Apoptosis related Synthetic Lethality STAT TNF-alpha Ras
Other Antioxidant Inhibitors	Elamipretide (SS-31, MTP-131) (+)-Catechin Hydroxygenkwanin Silymarin (-)Epicatechin Syringic acid Cocoa Extract Oleuropein Clematis apiifolia Extract Parsley Extract

Solubility

In vitro
Batch:

DMSO : 8 mg/mL (21.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 1 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	372.37	Formula	C₂₀H₂₀O₇	Storage (From the date of receipt)	3 years -20°C powder (seal)
CAS No.	481-53-8	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

In vitro

Tangeretin is a polymethoxylated flavonoid concentrated in the peel of citrus fruits. Recent studies have shown that this compound exhibits anti-proliferative, anti-invasive, anti-metastatic, and antioxidant activities. It at 2.7 μM induces apoptosis in human promyelocytic leukaemia HL-60 cells, whereas the flavone showed no cytotoxicity against human peripheral blood mononuclear cells (PBMCs). Further study shows that this chemical at 50 μM exerts its growth-inhibitory effects through modulation of the activities of several key G1 regulatory proteins such as Cdk2 and Cdk4, and mediates the increase of Cdk inhibitors p21 and p27. Pretreatment with it inhibites IL-1beta-induced p38 MAPK, JNK, and AKT phosphorylation and the downstream activation of NF-kappaB in human lung epithelial carcinoma cells (A549) and and human non-small cell lung carcinoma cells (H1299).

References

[1] https://pubmed.ncbi.nlm.nih.gov/8519648/
[2] https://pubmed.ncbi.nlm.nih.gov/12376477/
[3] https://pubmed.ncbi.nlm.nih.gov/17067555/

Tech Support

Handling Instructions

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