Home GPCR & G Protein GPCR19 activator Deoxycholic acid sodium salt

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Deoxycholic acid sodium salt GPCR19 activator

Cat.No.S3069

Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) is specifically responsible for activating the TGR5 receptor (GPCR19) that stimulates brown adipose tissue (BAT) thermogenic activity.

Deoxycholic acid sodium salt GPCR19 activator Chemical Structure

Chemical Structure

Molecular Weight: 414.55

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Quality Control

Batch: S306901 DMSO]83 mg/mL]false]Water]83 mg/mL]false]Ethanol]83 mg/mL]false Purity: 99.35%
99.35

Solubility

In vitro
Batch:

DMSO : 83 mg/mL (200.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 83 mg/mL

Ethanol : 83 mg/mL

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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%
% Tween 80
% ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 414.55 Formula

C24H39NaO4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 302-95-4 -- Storage of Stock Solutions

Synonyms Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA Smiles [Na+].CC(CCC([O-])=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C

Mechanism of Action

Targets/IC50/Ki
GPCR19
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01632917 Completed
Healthy
Kythera Biopharmaceuticals
 June 2012 Phase 1
NCT01462786 Completed
Healthy
Kythera Biopharmaceuticals
 October 2011 Phase 1
NCT01319916 Completed
Healthy
Kythera Biopharmaceuticals
 December 2010 Phase 1

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