Home Metabolism P450 (e.g. CYP17) inhibitor Salvianolic acid C For research use only.

Salvianolic acid C

Salvianolic acid C is a non-competitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2).

Salvianolic acid C Chemical Structure

Salvianolic acid C Chemical Structure

CAS: 115841-09-3

Purity & Quality Control

Batch: S092201 DMSO] 98 mg/mL] false] Ethanol] 98 mg/mL] false] Water] Insoluble] false Purity: 99.95%
99.95

Salvianolic acid C Related Products

Signaling Pathway

P450 (e.g. CYP17) Signaling Pathways

P450 (e.g. CYP17) Signaling Pathway

Choose Selective P450 (e.g. CYP17) Inhibitors

Biological Activity

Description Salvianolic acid C is a non-competitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2).
Targets
CYP2C8 [1] CYP2J2 [1]
4.82 μM(Ki) 5.75 μM(Ki)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03908242 Unknown status
Diabetes
Peking University First Hospital
 April 8 2019 Phase 1
NCT03791463 Unknown status
Healthy
Peking University First Hospital
 December 20 2018 Phase 1
NCT03791125 Unknown status
Neuropathy of Diabetes
Peking University First Hospital|Shandong Huizhi Pharmaceutical Technology Co. Ltd.|Cancer Institute and Hospital Chinese Academy of Medical Sciences
 November 20 2018 Phase 1

Chemical Information & Solubility

Molecular Weight 492.43 Formula

C26H20O10
CAS No. 115841-09-3 SDF --
Smiles C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=C3C=C(OC3=C(C=C2)O)C4=CC(=C(C=C4)O)O)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 98 mg/mL ( (199.01 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 98 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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