||Bivalirudin Trifluoroacetate is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin.
||Abarelix Acetate is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research.
||Carbetocin Acetate is a long-acting oxytocin-analogue and a potent agonist of the oxytocin receptor (OXTR), with improved in vivo stability over oxytocin.
||Eptifibatide Acetate is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. A disulfide bridge forms between mercaptopropionyl and cysteine. Eptifibatide prevents platelet aggregation. One study shows the inhibition of platelet glycoprotein IIb/IIIa in acute coronary syndromes.
||Octreotide (SMS 201-995) acetate
||Octreotide (SMS 201-995) acetate is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.
||Cetrorelix Acetate (NS 75A Acetate, SB 075 Acetate, SB 75 Acetate) is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH) with an IC50 of 1.21 nM.
||Argpressin Acetate is a neurohypophysial hormone found in most mammals. It acts as a neurotransmitter at synapses in the brain, increases [Ca2+]i in cultured rat hippocampal neurons.
||Melanotan II is an analog of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH).
||Oxytocin(Syntocinon) is a nine amino acid peptide that is synthesized in hypothalamic neurons and transported down axons of the posterior pituitary for secretion into blood.
||CCK Octapeptide (Sincalide)
||CCK Octapeptide (Sincalide, Cholecystokinin Octapeptide, CCK-OP, CCK-8, SQ 19,844) is a endogenous peptide hormone found in the intestine and brain that stimulates digestion.
||Teriparatide Acetate is a recombinant form of parathyroid hormone, used in the treatment of some forms of osteoporosis
||Terlipressin Acetate is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.
||Thymosin β4 Acetate (0.95)
||Thymosin β4 Acetate (0.95) is a 43 amino acid peptide which is regarded as the main intracellular G-actin sequestering peptide.
||Somatostatin Acetate is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.
||Exenatide Acetate (Exendin-4)
||Exenatide Acetate (Exendin-4), a 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus.
||Felypressin-Acetate is a non-catecholamine vasoconstrictor that is chemically associated to vasopressin, the posterior pituitary hormone.
||Glucagon monohydrochloride stimulates glycogenolysis in the liver, used as an antihypoglycemic and as an adjunct in gastrointestinal radiography.
||Nafarelin Acetate is a Gonadotropin-releasing hormone (GnRH) agonist; synthetic decapeptide analog of GnRH (luteinizing hormone-releasing hormone, gonadorelin); structurally related to goserelin, leuprolide, and triptorelin.
||Pramlintide Acetate is a prescription drug that can lower blood sugar in people with diabetes.
||Ganirelix acetate (Antagon)
||Ganirelix acetate (Antagon,Orgalutran) is a synthetic decapeptide with high antagonistic activity against naturally occurring gonadotropin-releasing hormone (GnRH).
||Ziconotide is a selective blocker of neuronal N-type voltage-sensitive calcium channels and antinociceptive when it is administered intrathecally.(ED50= 0.1 μg (49 pmol))
||Desmopressin is a synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. It is a selective agonist for the vasopressin V2 receptor (V2R).
||Angiotensin II human Acetate
||Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. It works via binding to specific receptors present on cell membranes.
||Carperitide Acetate (alpha-human atrial natriuretic peptide)
||Carperitide is a potent natriuretic peptide receptor (NPR)-A agonist with EC50 of 10.8 nM. Carperitide is used to treat congestive heart failure.
Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, Ipstyl, ITM-014, Somatulina, Somatuline, Lanreotidum) acetate, an analog of the native somatostatin peptide, is a physiological inhibitor of growth hormone (GH). Lanreotide also has antitumoral effects.
||Goserelin is a luteinizing hormone releasing hormone (LHRH) agonist, which is used to suppress production of the sex hormones. Goserelin acetate is an injectable gonadotropin releasing hormone superagonist (GnRH agonist).
||Protirelin (Thyrotropin-releasing-hormone, TRH, Thyroliberin) acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.
||Abatacept (Orencia, CTLA4lg, BMS-188667) is a recombinant DNA generated fusion protein that comprises the extracellular domain of human CTLA-4 fused to the Fc portion of human IgG1 and antagonizes CD28-mediated T cells.
Abaloparatide (BA058, BIM-44058, ITM-058) is a novel 34-amino acid peptide selected to be a potent and selective activator of the parathyroid hormone receptor (PTH1R) signaling pathway with an IC50 of 0.117 nM in SOST analysis.
Deslorelin Acetate is a synthetic analogue of gonadotrophin-releasing hormone (GnRH) that acts as a potent GnRH agonist.
||Degarelix acetate (ASP-3550 acetate) is a potent and long-acting luteinizing hormone-releasing hormone (LHRH) antagonist.
||BAM(8-22), a proteolytically cleaved product of proenkephalin A, is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1, and induces scratching in mice in an Mrgpr-dependent manner.
Glatiramer acetate is a synthetic copolymer composed of a random mixture of four amino acids that modifies the immune response.
||Bulevirtide (Myrcludex B)
||Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt transport.
||D-JNKI-1 (AM-111, XG-102) is a highly and cell-permeable peptide inhibitor of JNK.
||Alamandine is a component of the renin-angiotensin system, which regulates blood pressure.
||Bremelanotide Acetate (PT-141 Acetate) is a melanocortin receptor (MCR) agonist recently approved in the USA for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty.
||Linaclotide is a potent and selective guanylate cyclase C (GC-C) agonist that elicits pharmacological effects locally in the gastrointestinal tract.
||Etelcalcetide HCl (AMG 416) is a novel synthetic peptide agonist of the calcium-sensing receptor (CaSR) composed of a linear chain of seven d-amino acids with a d-cysteine linked to an l-cysteine via a disulfide bond.
||Tesamorelin, is a synthetic growth-hormone-releasing hormone (GHRH) analogue used clinically for the treatment of HIV-associated lipodystrophy (dysfunctional fat deposition).
||GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R).
||IPamorelin acetate, a Growth Hormone Releasing Peptide (GHRP) that stimulates the pituitary gland within the body to release natural growth hormone (GH), stimulates GH release from rat primary pituitary cells in a dose-dependent manner with an EC50 of 1.4 nM.
||Dasiglucagon, a stable peptide analog of human glucagon, is a fast and effective treatment option for severe hypoglycemia.
||Dulaglutide is a GLP-1 receptor agonist approved for the management of hyper glycaemia in people with type 2 diabetes in many countries.
||Epitalon is an anti-aging agent and a telomerase activator, with an inhibitory effect of the on the development of spontaneous tumors in mice, as well as geroprotective actions and intranasal administration increases neuronal activity, also can be used for cancer, old age and Retinitis Pigmentosa.
||[Leu5]Enkephalin a five amino acid endogenous peptide that acts as an agonist at opioid receptors.
||Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin, showing inhibition of neuropathic pain.
Bombesin, a tetradecapeptide, plays an important role in the release of gastrin and the activation of G-protein receptors.
||GLP-1(7-36) amide human
GLP-1(7-36) amide human (Glucagon-like peptide-I(7-36) amide) is a physiological incretin hormone that stimulates insulin secretion.
Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis.
||Neuropeptide Y (human, rat)
Neuropeptide Y (human, rat) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.
Obestatin(human) is a 23-amino acid amidated peptide that regulates appetite and gastrointestinal motility via its interaction with GPR39. Obestatin(human) can be used for weight loss.
Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities.
||Peptide YY (3-36) (human)
Peptide YY (3-36) (human) is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion.
||Peptide YY (human)
Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.
Pasireotide (SOM230), a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors. Pasireotide can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide also exhibits antisecretory, antiproliferative, and proapoptotic activity.
Sermorelin, a 29 amino acid analogue of human growth hormone-releasing hormone (GHRH), is the shortest synthetic peptide with full biological activity of GHRH.
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
Xenin is a 25-amino acid peptide initially isolated from human gastric mucosa. Xenin is a gut hormone that can reduce food intake.
Dynorphin (1-17) (Dynorphin A (swine)), an endogenous opioid peptide, is a highy potent kappa opioid receptor (KOR) activator. Dynorphin A also serve as an agonist for other opioid receptors, such as mu (MOR) and delta (DOR).
Kassinin is a peptide derived from the Kassina frog. Kassinin belongs to tachykinin family of neuropeptides. Kassinin is secreted as a defense response, involving in neuropeptide signalling.
||Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).
||Gastrin Tetrapeptide (Cholecystokinin tetrapeptide, tetragastrin, CCK-4) is the C-terminal tetrapeptide of gastrin, can stimulate gastric secretion, also is a cholecystokinin (CCK)-4 receptor agonist, with the effect of gastric mucosal protection.
||HIV Peptide T
||HIV Peptide T (Peptide T), a synthetic octapeptide and an antiviral agent for use in HIV infection, of which mechanism of action consists of competitive inhibition of the binding of gp120 (a surface protein of HIV) to the CD4 receptor, homologous binding to vasointestinal peptide (VIP) receptors, and blockade of cytokine production and function.
||Thymulin (FTS) is a neuroendocrine hormone with immunoregulatory actions, with anti-inflammatory potential by downregulating the release of inflammatory mediators, such as cytokines and chemokines, upregulating anti-inflammatory factors, such as interleukin (IL)-10, exerting molecular control via the regulation of transcription factors and mediators.
||Semax (Met-Glu-His-Phe-Pro-Gly-pro) is an analog of the adrenocorticotropic hormone fragment, which activates the transcription of neurotrophic factors and has neuroprotective and pro-intellectual activities.
Abarelix (R3827; PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment.
Nesiritide (Brain Natriuretic Peptide-32 human; BNP-32) is an agonist of natriuretic peptide receptors (NPRs).
Antide, a Gonadotropin-releasing hormone antagonist, inhibits apoptosis of preovulatory follicle cells in rat ovary.
GLP-1(7-37) is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.
||Argipressin Acetate binds to the V1, V2, V3-vascular arginine vasopressin (AVP) receptors, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1-vascular vasopressin (AVP) receptor.
||BPC157 (Bepecin, PL 14736), a small, chemically synthesised pentadecapeptide and a partial sequence of the human gastric juice protein BPC, which has been shown to be safe in clinical trials for inflammatory bowel disease and may be able to cure intestinal anastomosis dehiscence.
||Difelikefalin (CR-845, FE-202845), a peripherally restricted and selective agonist of kappa opioid receptor (KOR), produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.
||Oglufanide (H-Glu-Trp-OH, L-Glutamyl-L-tryptophan), a dipeptide immunomodulator isolated from calf thymus, inhibits vascular endothelial growth factor (VEGF), also stimulates the immune response to hepatitic C virus (HCV) and intracellular bacterial infections.
||PKG inhibitor peptide
||PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM.
||PKI 14-22 amide,myristoylated
||PKI 14-22 amide, myristoylated is a potent cAMP-dependent PKA inhibitor, which can reduce the IgG-mediated phagocytic response and also inhibits neutrophil adhesion.
||CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA substrate.
||Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase, which is a highly specific substrate for PKA with a Km of 15 μM.
||Autocamtide 2, amide
||Autocamtide 2, amide is a substrate for Calcium/Calmodulin Stimulated Protein Kinase (CaMK) family assays.
||Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide, is a selective PKCε inhibitor, which can inhibit the translocationof PKCε, but not α-, β-, and δ-PKC.
||Angstrom6 (A6 Peptide) is a capped, eight l-amino acid peptide (Ac-KPSSPPEE-NH2) derived from the biologically active connecting peptide domain of the serine protease, human urokinase plasminogen activator (uPA), which can binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling.
||LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA)
||LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA), a small molecular peptide and competitive antagonist for transforming growth factor-β1 (TGF-β1), protects against subarachnoid fibrosis and hydrocephalus after subarachnoid hemorrhage (SAH).
||Pep2m, myristoylated (TFA)
||Pep2m, myristoylated (TFA) is a cell-permeable peptide, which can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions.
||Sakamototide substrate peptide (TFA)
||Sakamototide substrate peptide TFA is a peptide substrate for members of the AMPK family of kinases, used in kinase activity assays.
||pm26TGF-β1 peptide (TFA)
||Pm26TGF-β1 peptide TFA is a peptide is a portion of the human TGF-β1 molecule, which shows high affinity for the TGF-β1 receptor.
||CDK7/9 tide is a peptide substrate for CDK7 or CDK9.
||LL37 (Human cathelicidin)
||LL37 (Human cathelicidin, Ropocamptide) is a cathelicidin-related antimicrobial peptide with potent chemotactic and immunomodulatory properties.
TMPyP4 tosylate (TMP 1363), a quadruplex-specific ligand, inhibits the interaction between G-quadruplex (G4) and IGF-1 (Insulin-like growth factor type I). TMPyP4 tosylate is also a telomerase inhibitor with antitumor effects.
||Avexitide (Exendin (9-39)) is a specific and competitive antagonist of glucagon-like peptide-1 (GLP-1) receptor.
||Myelin Oligodendrocyte Glycoprotein 35-55, mouse, rat
||Myelin Oligodendrocyte Glycoprotein 35-55, mouse, rat (MOG 35-55) is a minor component of CNS myelin that induces experimental autoimmune encephalomyelitis in C57BL/6 mice by an encephalitogenic T cell response.
||GsMTx4 (Grammostola spatulata mechanotoxin 4, M-theraphotoxin-Gr1a, M-TRTX-Gr1a) is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs).
||Tirzepatide (LY3298176, GIP/GLP-1 RA, TZP) is a dual GIP/GLP-1 receptor agonist. Tirzepatide differentially induces internalization of the GIP and GLP-1 receptors with EC50 values of 18.2 nM and 18.1 nM, respectively.
alpha-MSH TFA (α-MSH TFA, α-MSH Trifluoroacetate, alpha-MSH Trifluoroacetate,α-Melanocyte-stimulating hormone TFA, α-Melanocyte-stimulating hormone Trifluoroacetate) is a 13-amino acid peptide hormone. an endogenous MC4R agonist. alpha-MSH TFA is an endogenous MC3R and MC4R agonist with EC50s of 0.16 nM and 56 nM for hMC3R and hMC4R in Hepa cells, respectively.
PMX 205 is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.
||LQP-21 TFA (TLQP-21 Trifluoroacetate) is a VGF-derived peptide that activates the C3aR1 receptor through a folding-upon-binding mechanism.
||11R-VIVIT TFA (NFAT inhibitor), a short peptide, inhibits NFAT activation through interaction with the calcineurin binding site for NFAT and thus prevents nuclear translocation without affecting calcineurin phosphatase activity.
Apelin-13 can efficiently antagonize the APJ receptor with EC50 of 0.37 nM and result in suppress the forskolin-stimulated cAMP production.
(Ala13)-Apelin-13 is a potent APJ receptor antagonist and can prevent the apelin-induced reduction in gastric tone and motility.
||gp91ds-tat, a peptide inhibitor for NADPH oxidase assembly, is composed of gp91phox sequence linked to the human immunodeficiency virus-tat peptide. The tat sequence facilitates the entry of this peptide into cells.
||BM213, a selective C5aR1 agonist with an EC50 of 59 nM, induces C5aR1-mediated calcium mobilization and pERK1/2 signaling but not β-arrestin recruitment. BM213 is much more stable in serum and displays no cytotoxicity on SHSY-5Y cells.
||Box5, a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist, inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling.
||Disitertide (P144) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor, is also a PI3K inhibitor and an apoptosis inducer.
||Tat-NR2B9c (Tat-NR2Bct, NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC50 values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively, and disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC50 values of 0.5 μM and 8 μM, respectively, also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy.
||CYN154806, a cyclic octapeptide, is a potent and selective somatostatin SST2 receptor antagonist, with pIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant SST2, SST1, SST3, SST4 and SST5 receptors respectively.