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Modulation of AÎ² aggregation and cytotoxicity by FLN. (A) CD spectra of AÎ² monomer incubated for 7 days at 37Â°C in the absence (AÎ² aggregate) or presence of 10x FLN (FLN). (B) TEM images of 50 Î¼M of AÎ² incubated for seven days at 37Â°C in the absence of any dye (AÎ² only), or in the presence of 3x FLN. Scale bar is 100 nm. (C) Dot blot images of AÎ² aggregates formed without (AÎ² only) or with 3x and 10x FLN using OC and 4G8 antibodies. For each antibody, all samples were spotted onto one nitrocellulose membrane. Each membrane was immuno-stained with the OC or 4G8 antibody. For clearer presentation of the data, the sections of each membrane were cut and re-arranged. (D) Viability of neuroblastoma SH-SY5Y cells. Three controls (PBS buffer, AÎ² monomer, and FLN) and two AÎ² aggregates formed in the absence or presence of 3x FLN at 37Â°C for 5 days. Values represent means Â± standard deviation (nâ¥3). Values are normalized to the viability of cells administered with PBS buffer only. Two-sided Studentâs t-tests were applied to the MTT reduction data. (*; P = 0.013).
CD spectra of AÎ² monomer and preformed AÎ² aggregates. (A) CD spectra of AÎ² monomer, AÎ² aggregates formed in the absence or presence of 10x EOB or PHB for 5 days at 37Â°C. (B) CD spectra of AÎ² aggregates formed in the absence or presence of 10x EOY, ERB, or ROB for 5 days at 37Â°C.
Directed folding of peptides containing four cysteine residues to bicyclic structures. a, The two CXC motifs in peptide 9 strongly promote the formation of a fused bicyclic structure. b, The CXC motif in 10 directs the intramolecular pairing of cysteine residues to two products and does not promote the formation of peptide dimers. c, The four isolated cysteine residues in 11 oxidize to form three products in statistically expected ratios. Oligomerization of 9â11 is never observed. Disulfide pairing was established by tryptic digestion LC-MS (Supplementary Figs S6âS10). aa, amino acid.
Using an in vitro approach with purified and titrated matriptase and internally-quenched fluorescent octapeptide mimetics (IQFPs) of the consensus cleavage sequences of H1, H2, and H3 we show that, at physiological pH, matriptase was capable of cleaving both the H1 (IQSRGLFG) and H3 (KQTRGLFG) consensus cleavage sequences, whereas no cleavage was observed with the H2 (IESRGLFG) consensus sequence (Figure A). V max was 8.52 Â± 0.76 FU min-1 nmole-1 for H1 cleavage and 16.53 Â± 2.38 FU min-1 nmole-1 for H3 cleavage. Trypsin (not normally expressed in the lungs) was used as a control in this assay and our data showed that trypsin cleaved all three consensus sequences with similar efficiency (Vmax of 364.37 Â± 28.90 FU min-1 nmole-1 for H1, 312.17 Â± 52.32 FU min-1 nmole-1 for H2 and 277.13 Â± 4.11 FU min-1 nmole-1 for H3.
Cardiovascular effects of PACAP and PACAP(6â38) in the RVLM of normotensive and hypertensive rats. A and B: changes in mean arterial pressure (MAP; i), HR (ii), and percentage of sSNA (iii) before and after the administration of PACAP (A) or PACAP(6â38) (B). Arrows indicate times of drug infusion. âPBSâ indicates the period after the bilateral RVLM microinjection of PBS; âPACAPâ and âPACAP(6â38)â indicate the periods after the bilateral RVLM microinjection of PACAP or PACAP(6â38), respectively. C: comparison of maximum MAP (i), HR (ii), and percentage of sSNA responses (iii) after PACAP or PACAP(6â38). *P < 0.05; **P < 0.01; ***P < 0.001.
|P1004||Bivalirudin Trifluoroacetate||Bivalirudin Trifluoroacetate is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin.|
|P1011||Eptifibatide Acetate||Eptifibatide Acetate is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. A disulfide bridge forms between mercaptopropionyl and cysteine. Eptifibatide prevents platelet aggregation. One study shows the inhibition of platelet glycoprotein IIb/IIIa in acute coronary syndromes.|
|P1013||Leuprorelin||Leuprorelin is an agonist at pituitary GnRH receptors.|
|P1017||Octreotide Acetate||Octreotide Acetate is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.|
|P1020||Argpressin Acetate||Argpressin Acetate is a neurohypophysial hormone found in most mammals. It acts as a neurotransmitter at synapses in the brain, increases [Ca2+]i in cultured rat hippocampal neurons.|
|P1022||Desmopressin (DDAVP)||Desmopressin (STIMATE, DDAVP, Minirin) is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation.|
|P1027||Melanotan II||Melanotan II is an analog of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH).|
|P1029||Oxytocin (Syntocinon)||Oxytocin(Syntocinon) is a nine amino acid peptide that is synthesized in hypothalamic neurons and transported down axons of the posterior pituitary for secretion into blood.|
|P1033||Teriparatide Acetate||Teriparatide Acetate is a recombinant form of parathyroid hormone, used in the treatment of some forms of osteoporosis|
|P1034||Terlipressin Acetate||Terlipressin Acetate is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.|
|P1036||Thymosin β4 Acetate (0.95)||Thymosin β4 Acetate (0.95) is a 43 amino acid peptide which is regarded as the main intracellular G-actin sequestering peptide.|
|P1039||Somatostatin Acetate||Somatostatin Acetate is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.|
|P1046||Exenatide Acetate||Exenatide Acetate, a 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus.|
|P1047||Felypressin Acetate||Felypressin-Acetate is a non-catecholamine vasoconstrictor that is chemically associated to vasopressin, the posterior pituitary hormone.|
|P1056||Glucagon HCl||Glucagon HCl stimulates glycogenolysis in the liver, used as the hydrochloride salt as an antihypoglycemic and as an adjunct in gastrointestinal radiography.|
|P1061||Nafarelin Acetate||Nafarelin Acetate is a Gonadotropin-releasing hormone (GnRH) agonist; synthetic decapeptide analog of GnRH (luteinizing hormone-releasing hormone, gonadorelin); structurally related to goserelin, leuprolide, and triptorelin.|