P1004 |
Bivalirudin Trifluoroacetate |
Bivalirudin Trifluoroacetate is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. |
P1008 |
Carbetocin Acetate |
Carbetocin Acetate is a long-acting oxytocin-analogue and a potent agonist of the oxytocin receptor (OXTR), with improved in vivo stability over oxytocin. |
P1011 |
Eptifibatide Acetate |
Eptifibatide Acetate is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. A disulfide bridge forms between mercaptopropionyl and cysteine. Eptifibatide prevents platelet aggregation. One study shows the inhibition of platelet glycoprotein IIb/IIIa in acute coronary syndromes. |
P1013 |
Leuprorelin |
Leuprorelin is an agonist at pituitary GnRH receptors. |
P1017 |
Octreotide (SMS 201-995) acetate |
Octreotide (SMS 201-995) acetate is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. |
P1019 |
Cetrorelix Acetate |
Cetrorelix Acetate (NS 75A Acetate, SB 075 Acetate, SB 75 Acetate) is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH) with an IC50 of 1.21 nM. |
P1020 |
Argpressin Acetate |
Argpressin Acetate is a neurohypophysial hormone found in most mammals. It acts as a neurotransmitter at synapses in the brain, increases [Ca2+]i in cultured rat hippocampal neurons. |
P1027 |
Melanotan II |
Melanotan II is an analog of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH). |
P1029 |
Oxytocin (Syntocinon) |
Oxytocin(Syntocinon) is a nine amino acid peptide that is synthesized in hypothalamic neurons and transported down axons of the posterior pituitary for secretion into blood. |
P1032 |
CCK Octapeptide (Sincalide) |
CCK Octapeptide (Sincalide, Cholecystokinin Octapeptide, CCK-OP, CCK-8, SQ 19,844) is a endogenous peptide hormone found in the intestine and brain that stimulates digestion. |
P1033 |
Teriparatide Acetate |
Teriparatide Acetate is a recombinant form of parathyroid hormone, used in the treatment of some forms of osteoporosis |
P1034 |
Terlipressin Acetate |
Terlipressin Acetate is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help. |
P1036 |
Thymosin β4 Acetate (0.95) |
Thymosin β4 Acetate (0.95) is a 43 amino acid peptide which is regarded as the main intracellular G-actin sequestering peptide. |
P1039 |
Somatostatin Acetate |
Somatostatin Acetate is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. |
P1046 |
Exenatide Acetate (Exendin-4) |
Exenatide Acetate (Exendin-4), a 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. |
P1047 |
Felypressin Acetate |
Felypressin-Acetate is a non-catecholamine vasoconstrictor that is chemically associated to vasopressin, the posterior pituitary hormone. |
P1056 |
Glucagon monohydrochloride |
Glucagon monohydrochloride stimulates glycogenolysis in the liver, used as an antihypoglycemic and as an adjunct in gastrointestinal radiography. |
P1061 |
Nafarelin Acetate |
Nafarelin Acetate is a Gonadotropin-releasing hormone (GnRH) agonist; synthetic decapeptide analog of GnRH (luteinizing hormone-releasing hormone, gonadorelin); structurally related to goserelin, leuprolide, and triptorelin. |
P1063 |
Pramlintide Acetate |
Pramlintide Acetate is a prescription drug that can lower blood sugar in people with diabetes. |
P1070 |
Ziconotide Acetate |
Ziconotide is a selective blocker of neuronal N-type voltage-sensitive calcium channels and antinociceptive when it is administered intrathecally.(ED50= 0.1 μg (49 pmol)) |
P1072 |
CJC-1295 |
CJC-1295 is a long-acting GHRH analog and stimulates GH and IGF-1 secretion. |
P1083 |
ZIP |
Pkc Inhibitor |
P1084 |
Desmopressin Acetate |
Desmopressin is a synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. It is a selective agonist for the vasopressin V2 receptor (V2R). |
P1085 |
Angiotensin II human Acetate |
Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. It works via binding to specific receptors present on cell membranes. |
P1087 |
Carperitide Acetate (alpha-human atrial natriuretic peptide) |
Carperitide is a potent natriuretic peptide receptor (NPR)-A agonist with EC50 of 10.8 nM. Carperitide is used to treat congestive heart failure. |
P1088 |
Lanreotide acetate |
Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, Ipstyl, ITM-014, Somatulina, Somatuline, Lanreotidum) acetate, an analog of the native somatostatin peptide, is a physiological inhibitor of growth hormone (GH). Lanreotide also has antitumoral effects.
|
P1089 |
Goserelin Acetate |
Goserelin is a luteinizing hormone releasing hormone (LHRH) agonist, which is used to suppress production of the sex hormones. Goserelin acetate is an injectable gonadotropin releasing hormone superagonist (GnRH agonist). |
P1090 |
Protirelin Acetate |
Protirelin (Thyrotropin-releasing-hormone, TRH, Thyroliberin) acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions. |
P1091 |
Abatacept |
Abatacept (Orencia, CTLA4lg, BMS-188667) is a recombinant DNA generated fusion protein that comprises the extracellular domain of human CTLA-4 fused to the Fc portion of human IgG1 and antagonizes CD28-mediated T cells. |
P1092 |
Abaloparatide (BA058) |
Abaloparatide (BA058, BIM-44058, ITM-058) is a novel 34-amino acid peptide selected to be a potent and selective activator of the parathyroid hormone receptor (PTH1R) signaling pathway with an IC50 of 0.117 nM in SOST analysis.
|
P1093 |
Deslorelin Acetate |
Deslorelin Acetate is a synthetic analogue of gonadotrophin-releasing hormone (GnRH) that acts as a potent GnRH agonist.
|
P1094 |
Degarelix acetate |
Degarelix acetate (ASP-3550 acetate) is a potent and long-acting luteinizing hormone-releasing hormone (LHRH) antagonist. |
P1104 |
Glatiramer acetate |
Glatiramer acetate is a synthetic copolymer composed of a random mixture of four amino acids that modifies the immune response.
|
P1105 |
Bulevirtide (Myrcludex B) |
Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt transport. |
P1107 |
Alamandine |
Alamandine is a component of the renin-angiotensin system, which regulates blood pressure. |
P1108 |
Bremelanotide Acetate |
Bremelanotide Acetate (PT-141 Acetate) is a melanocortin receptor (MCR) agonist recently approved in the USA for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty. |
P1119 |
Bombesin |
Bombesin, a tetradecapeptide, plays an important role in the release of gastrin and the activation of G-protein receptors.
|
P1120 |
GLP-1(7-36) amide human |
GLP-1(7-36) amide human (Glucagon-like peptide-I(7-36) amide) is a physiological incretin hormone that stimulates insulin secretion.
|
P1121 |
Plecanatide |
Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis.
|
P1122 |
Neuropeptide Y (human, rat) |
Neuropeptide Y (human, rat) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.
|
P1123 |
Obestatin(human) |
Obestatin(human) is a 23-amino acid amidated peptide that regulates appetite and gastrointestinal motility via its interaction with GPR39. Obestatin(human) can be used for weight loss.
|
P1124 |
Obestatin(rat) |
Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities.
|
P1125 |
Peptide YY (3-36) (human) |
Peptide YY (3-36) (human) is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion[1].
|
P1126 |
Peptide YY (human) |
Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.
|
P1127 |
Pasireotide |
Pasireotide (SOM230), a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors. Pasireotide can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide also exhibits antisecretory, antiproliferative, and proapoptotic activity.
|
P1128 |
Sermorelin |
Sermorelin, a 29 amino acid analogue of human growth hormone-releasing hormone (GHRH), is the shortest synthetic peptide with full biological activity of GHRH.
|
P1129 |
Substance P |
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
|
P1130 |
Xenin |
Xenin is a 25-amino acid peptide initially isolated from human gastric mucosa. Xenin is a gut hormone that can reduce food intake.
|
P1131 |
Dynorphin (1-17) |
Dynorphin (1-17) (Dynorphin A (swine)), an endogenous opioid peptide, is a highy potent kappa opioid receptor (KOR) activator. Dynorphin A also serve as an agonist for other opioid receptors, such as mu (MOR) and delta (DOR)[1].
|
P1132 |
Kassinin |
Kassinin is a peptide derived from the Kassina frog. Kassinin belongs to tachykinin family of neuropeptides. Kassinin is secreted as a defense response, involving in neuropeptide signalling.
|
P1142 |
Abarelix |
Abarelix (R3827; PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer treatment.
|
P1143 |
Nesiritide |
Nesiritide (Brain Natriuretic Peptide-32 human; BNP-32) is an agonist of natriuretic peptide receptors (NPRs).
|
P1144 |
Antide |
Antide, a Gonadotropin-releasing hormone antagonist, inhibits apoptosis of preovulatory follicle cells in rat ovary.
|
P1145 |
GLP-1 (7-37) |
GLP-1(7-37) is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.
|
P1201 |
LL37 (Human cathelicidin) |
LL37 (Human cathelicidin, Ropocamptide) is a cathelicidin-related antimicrobial peptide with potent chemotactic and immunomodulatory properties. |
P1202 |
TMPyP4 tosylate |
TMPyP4 tosylate (TMP 1363), a quadruplex-specific ligand, inhibits the interaction between G-quadruplex (G4) and IGF-1 (Insulin-like growth factor type I). TMPyP4 tosylate is also a telomerase inhibitor with antitumor effects. |
P1203 |
Avexitide |
Avexitide (Exendin (9-39)) is a specific and competitive antagonist of glucagon-like peptide-1 (GLP-1) receptor. |
P1204 |
Myelin Oligodendrocyte Glycoprotein 35-55, mouse, rat |
Myelin Oligodendrocyte Glycoprotein 35-55, mouse, rat (MOG 35-55) is a minor component of CNS myelin that induces experimental autoimmune encephalomyelitis in C57BL/6 mice by an encephalitogenic T cell response. |
P1205 |
GsMTx4 |
GsMTx4 (Grammostola spatulata mechanotoxin 4, M-theraphotoxin-Gr1a, M-TRTX-Gr1a) is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs). |
P1206 |
Tirzepatide (LY3298176) |
Tirzepatide (LY3298176, GIP/GLP-1 RA, TZP) is a dual GIP/GLP-1 receptor agonist. Tirzepatide differentially induces internalization of the GIP and GLP-1 receptors with EC50 values of 18.2 nM and 18.1 nM, respectively. |
P1207 |
alpha-MSH TFA |
alpha-MSH TFA (α-MSH TFA, α-MSH Trifluoroacetate, alpha-MSH Trifluoroacetate,α-Melanocyte-stimulating hormone TFA, α-Melanocyte-stimulating hormone Trifluoroacetate) is a 13-amino acid peptide hormone. an endogenous MC4R agonist. alpha-MSH TFA is an endogenous MC3R and MC4R agonist with EC50s of 0.16 nM and 56 nM for hMC3R and hMC4R in Hepa cells, respectively.
|
P1208 |
PMX 205 |
PMX 205 is a cyclic hexapeptide that acts as a potent C5a receptor (C5aR, CD88) antagonist with an IC50 of 31 nM.
|
P1209 |
TLQP-21 TFA |
LQP-21 TFA (TLQP-21 Trifluoroacetate) is a VGF-derived peptide that activates the C3aR1 receptor through a folding-upon-binding mechanism. |
P1210 |
11R-VIVIT TFA |
11R-VIVIT TFA (NFAT inhibitor), a short peptide, inhibits NFAT activation through interaction with the calcineurin binding site for NFAT and thus prevents nuclear translocation without affecting calcineurin phosphatase activity. |
P1211 |
Apelin-13 |
Apelin-13 can efficiently antagonize the APJ receptor with EC50 of 0.37 nM and result in suppress the forskolin-stimulated cAMP production.
|
P1212 |
(Ala13)-Apelin-13 |
(Ala13)-Apelin-13 is a potent APJ receptor antagonist and can prevent the apelin-induced reduction in gastric tone and motility.
|
P1213 |
gp91ds-tat |
gp91ds-tat, a peptide inhibitor for NADPH oxidase assembly, is composed of gp91phox sequence linked to the human immunodeficiency virus-tat peptide. The tat sequence facilitates the entry of this peptide into cells. |
P1215 |
BM213 |
BM213, a selective C5aR1 agonist with an EC50 of 59 nM, induces C5aR1-mediated calcium mobilization and pERK1/2 signaling but not β-arrestin recruitment. BM213 is much more stable in serum and displays no cytotoxicity on SHSY-5Y cells. |