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Besides peptide synthesis services, Selleck provides peptide products with high quality and purity at a competitive price. If you cannot find your peptide of interest from our catalog of peptides, please feel free to contact us by email [email protected] and we will provide the custom peptide synthesis services for you.

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  • Modulation of Aβ aggregation and cytotoxicity by FLN. (A) CD spectra of Aβ monomer incubated for 7 days at 37°C in the absence (Aβ aggregate) or presence of 10x FLN (FLN). (B) TEM images of 50 μM of Aβ incubated for seven days at 37°C in the absence of any dye (Aβ only), or in the presence of 3x FLN. Scale bar is 100 nm. (C) Dot blot images of Aβ aggregates formed without (Aβ only) or with 3x and 10x FLN using OC and 4G8 antibodies. For each antibody, all samples were spotted onto one nitrocellulose membrane. Each membrane was immuno-stained with the OC or 4G8 antibody. For clearer presentation of the data, the sections of each membrane were cut and re-arranged. (D) Viability of neuroblastoma SH-SY5Y cells. Three controls (PBS buffer, Aβ monomer, and FLN) and two Aβ aggregates formed in the absence or presence of 3x FLN at 37°C for 5 days. Values represent means ± standard deviation (n≥3). Values are normalized to the viability of cells administered with PBS buffer only. Two-sided Student’s t-tests were applied to the MTT reduction data. (*; P = 0.013).

    CD spectra of Aβ monomer and preformed Aβ aggregates. (A) CD spectra of Aβ monomer, Aβ aggregates formed in the absence or presence of 10x EOB or PHB for 5 days at 37°C. (B) CD spectra of Aβ aggregates formed in the absence or presence of 10x EOY, ERB, or ROB for 5 days at 37°C.

    Directed folding of peptides containing four cysteine residues to bicyclic structures. a, The two CXC motifs in peptide 9 strongly promote the formation of a fused bicyclic structure. b, The CXC motif in 10 directs the intramolecular pairing of cysteine residues to two products and does not promote the formation of peptide dimers. c, The four isolated cysteine residues in 11 oxidize to form three products in statistically expected ratios. Oligomerization of 9–11 is never observed. Disulfide pairing was established by tryptic digestion LC-MS (Supplementary Figs S6–S10). aa, amino acid.

  • Using an in vitro approach with purified and titrated matriptase and internally-quenched fluorescent octapeptide mimetics (IQFPs) of the consensus cleavage sequences of H1, H2, and H3 we show that, at physiological pH, matriptase was capable of cleaving both the H1 (IQSRGLFG) and H3 (KQTRGLFG) consensus cleavage sequences, whereas no cleavage was observed with the H2 (IESRGLFG) consensus sequence (Figure A). V max was 8.52 ± 0.76 FU min-1 nmole-1 for H1 cleavage and 16.53 ± 2.38 FU min-1 nmole-1 for H3 cleavage. Trypsin (not normally expressed in the lungs) was used as a control in this assay and our data showed that trypsin cleaved all three consensus sequences with similar efficiency (Vmax of 364.37 ± 28.90 FU min-1 nmole-1 for H1, 312.17 ± 52.32 FU min-1 nmole-1 for H2 and 277.13 ± 4.11 FU min-1 nmole-1 for H3.

    Cardiovascular effects of PACAP and PACAP(6–38) in the RVLM of normotensive and hypertensive rats. A and B: changes in mean arterial pressure (MAP; i), HR (ii), and percentage of sSNA (iii) before and after the administration of PACAP (A) or PACAP(6–38) (B). Arrows indicate times of drug infusion. “PBS” indicates the period after the bilateral RVLM microinjection of PBS; “PACAP” and “PACAP(6–38)” indicate the periods after the bilateral RVLM microinjection of PACAP or PACAP(6–38), respectively. C: comparison of maximum MAP (i), HR (ii), and percentage of sSNA responses (iii) after PACAP or PACAP(6–38). *P < 0.05; **P < 0.01; ***P < 0.001.

Cat.No. Product Name Description
P1004 Bivalirudin Trifluoroacetate Bivalirudin Trifluoroacetate is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin.
P1011 Eptifibatide Acetate Eptifibatide Acetate is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. A disulfide bridge forms between mercaptopropionyl and cysteine. Eptifibatide prevents platelet aggregation. One study shows the inhibition of platelet glycoprotein IIb/IIIa in acute coronary syndromes.
P1013 Leuprorelin Leuprorelin is an agonist at pituitary GnRH receptors.
P1017 Octreotide (SMS 201-995) acetate Octreotide (SMS 201-995) acetate is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.
P1019 Cetrorelix Acetate Cetrorelix Acetate (NS 75A Acetate, SB 075 Acetate, SB 75 Acetate) is a man-made hormone that blocks the effects of <b>Gonadotropin Releasing Hormone (GnRH)</b> with an IC50 of 1.21 nM.
P1020 Argpressin Acetate Argpressin Acetate is a neurohypophysial hormone found in most mammals. It acts as a neurotransmitter at synapses in the brain, increases [Ca2+]i in cultured rat hippocampal neurons.
P1027 Melanotan II Melanotan II is an analog of the peptide hormone alpha-melanocyte stimulating hormone (α-MSH).
P1029 Oxytocin (Syntocinon) Oxytocin(Syntocinon) is a nine amino acid peptide that is synthesized in hypothalamic neurons and transported down axons of the posterior pituitary for secretion into blood.
P1033 Teriparatide Acetate Teriparatide Acetate is a recombinant form of parathyroid hormone, used in the treatment of some forms of osteoporosis
P1034 Terlipressin Acetate Terlipressin Acetate is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.
P1036 Thymosin β4 Acetate (0.95) Thymosin β4 Acetate (0.95) is a 43 amino acid peptide which is regarded as the main intracellular G-actin sequestering peptide.
P1039 Somatostatin Acetate Somatostatin Acetate is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.
P1046 Exenatide Acetate (Exendin-4) Exenatide Acetate (Exendin-4), a 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus.
P1047 Felypressin Acetate Felypressin-Acetate is a non-catecholamine vasoconstrictor that is chemically associated to vasopressin, the posterior pituitary hormone.
P1056 Glucagon Acetate Glucagon Acetate stimulates glycogenolysis in the liver, used as an antihypoglycemic and as an adjunct in gastrointestinal radiography.
P1061 Nafarelin Acetate Nafarelin Acetate is a Gonadotropin-releasing hormone (GnRH) agonist; synthetic decapeptide analog of GnRH (luteinizing hormone-releasing hormone, gonadorelin); structurally related to goserelin, leuprolide, and triptorelin.
P1063 Pramlintide Acetate Pramlintide Acetate is a prescription drug that can lower blood sugar in people with diabetes.
P1083 ZIP Pkc Inhibitor