Protein-protein Interaction Inhibitor Library

Catalog No.L8100

Offered in 96 or 384 well plate format

A unique collection of 188 protein-protein Interaction(PPI) Inhibitors used for high throughput screening(HTS) and high content screening(HCS).

Size Price  
Pre-dissolved In DMSO or Water
USD 4136

Selleck Chemicals compound library contributes and expedites
the investigation of treatments against COVID19

The researchers at the National Institute of Infectious Diseases, in Japan, successfully found anti-COVID19 drugs within 3 months of
screening FDA-approved drug library from Selleck Chemicals. They have already published this article doi: 10.1101/2020.04.14.039925.

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Protein-protein Interaction Inhibitor Library Contents

Cited by 73 Publications

Case Studies using Selleck Compound Libraries

  • Application of GPCR Compound Library in liver cancer
    Nature.2019;574(7777):268-272
  • Application of Kinase Inhibitor Library in colorectal cancer
    Nat Commun. 2019 16;10(1):2197
  • Application of FDA-approved Drug Library in antivirus
    Cell Res. 2019;29(9):739-753
  • Application of FDA-approved Drug Library in metabolism
    Mov Disord. 2019;34(3):323-334
  • Application of Epigenetics Compound Library in acute lymphoblastic leukemia
    Blood. 2019 17;134(16):1323-1336
  • Application of Inhibitor Library in tumor immunology
    Cancer Immunol Res.2017;5(9):790-803

Description & Advantages

•Protein-protein interactions (PPI) represent a vast class of therapeutic targets both inside and outside the cell.Inhibitors of a number of protein–protein interactions (PPIs) have emerged as potential anticancer drug candidates; 
 
•A unique collection of 188 protein-protein Interaction(PPI) Inhibitors used for high throughput screening(HTS) and high content screening(HCS);
 
•Targets PD-1/PD-L1, BCL family,Bromodomains, MDM2,HIV integrase,etc.  
 
•Some compounds have been approved by the FDA;
 
•Structurally diverse,medicinally active,and cell permeable;
 
•Rich documentation with structure and bioactivity information;
 
•NMR and HPLC validated to ensure high purity.       

Product Details

Formulation: 180 compounds pre-dissolved in 10mM DMSO, 2 compounds pre-dissolved in 10mM water, 4 compounds pre-dissolved in 2mM DMSO and 2 compounds pre-dissolved in 2mM water
Container: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Stability: in DMSO
in DMSO
Shipping: Blue ice or dry ice
Packaging: Inert gas

Protein-protein Interaction Inhibitor Library Composition

HTS Facility Partners

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