Home Immunology & Inflammation Immunology & Inflammation related chemical - NF-κB inhibitor - Interleukins inhibitor - Caspase inhibitor - Decarboxylase inhibitor Chelidonic acid

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Chelidonic acid Immunology & Inflammation related chemical

Cat.No.S5579

Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxyl acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. This compound inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. It is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM.
Chelidonic acid Immunology & Inflammation related chemical Chemical Structure

Chemical Structure

Molecular Weight: 184.10

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S557901 DMSO]4 mg/mL]false]]]false]]]false Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 184.10 Formula

C7H4O6

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 99-32-1 -- Storage of Stock Solutions

Synonyms Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid Smiles C1=C(OC(=CC1=O)C(=O)O)C(=O)O

Solubility

In vitro
Batch:

DMSO : 4 mg/mL (21.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
NF-κB [1]
Caspase-1 [1]
IL-6 [1]
glutamate decarboxylase [2]
In vitro
Chelidonic acid (also known as chelidonate) is a heterocyclic organic acid. It is a solid with a melting point between 158-160 °C and is soluble in hot water. This compound forms a dihydrate and can be synthesized through various methods, including the oxidation of chelidonine. This chemical exhibits tautomerism and has been studied for its potential biological activities.
In vivo
Chelidonic acid (also known as chelidonate) is a heterocyclic organic acid. It is a solid with a melting point between 152–153 °C. This compound is classified as an γ-pyrone, a type of compound where a ketone is attached to a carbon-carbon double bond within a six-membered ring. This chemical is found in several plant species, notably in the greater celandine (Chelidonium majus). The molecule can serve as a ligand in coordination chemistry.
References

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