Talatisamine

Catalog No.S9223

For research use only.

Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities.

Talatisamine Chemical Structure

CAS No. 20501-56-8

Purity & Quality Control

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Biological Activity

Description Talatisamine, a delphinine type alkaloid extracted from Aconitum talassicum, is a newly identified K+ channel blocker with hypotensive and antiarrhythmic activities.
Targets
IK channel [1]
()
146 μM
In vitro

Talatisamine is a specific blocker for IK channel. External application of talatisamine reversibly inhibited the delayed rectifier K+ current (IK) with an IC50 value of 146.0±5.8 μM in a voltage-dependent manner, but exhibited very slight blocking effect on the voltage-gated Na+ and Ca2+ currents even at the high concentration of 1-3 mM in rat hippocampal neurons. Talatisamine had no allosteric action on IK channel and was a pure blocker binding to the external pore entry of the channel[1].

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 35 mg/mL
(83.02 mM)


* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 421.57
Formula

C24H39NO5

CAS No. 20501-56-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN1CC2(CCC(C34C2CC(C31)C5(CC(C6CC4C5C6O)OC)O)OC)COC

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