Home Immunology & Inflammation Nrf2 activator - HDAC inhibitor - NF-κB inhibitor - ROS inhibitor - Heme Oxygenase activator Sulforaphane

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Sulforaphane Nrf2 activator

Cat.No.S5771

Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. This compound is also an inhibitor of histone deacetylase (HDAC) and NF-κB. It increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). It induces cell cycle arrest and apoptosis.
Sulforaphane Nrf2 activator Chemical Structure

Chemical Structure

Molecular Weight: 177.29

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Quality Control

Chemical Information, Storage & Stability

Molecular Weight 177.29 Formula

C6H11NOS2

 Storage (From the date of receipt) 2 years -20°C(in the dark) liquid
CAS No. 4478-93-7 -- Storage of Stock Solutions

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Mechanism of Action

Targets/IC50/Ki
Nrf2 [1]
HDAC [1]
NF-κB [1]
ROS [1]
HO-1 [1]
In vitro

Sulforaphane, reactive oxygen species (ROS) inhibitor, decrease the autophagy induced by CC90003, while cell death strengthens, confirming that this compound induces autophagy by activating ROS/p53.[3]
In vivo

Natural isothiocyanate and potent NRF2 activator sulforaphane reverses diet-induced obesity through a predominantly, but not exclusively, NRF2-dependent mechanism that requires a functional leptin receptor signaling and hyperleptinemia.[4]
References

Applications

Methods Biomarkers Images PMID
Western blot EGFR / p-EGFR / STAT3 / p-STAT3 / AKT / p-AKT β-catenin / Cyclin D1 S5771-WB2 26036303
Growth inhibition assay Cell viability S5771-viability1 30226534
Immunofluorescence Gli1 / Gli2 HER2 S5771-IF2 23029396

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03934905 Recruiting
Anthracycline Related Cardiotoxicity in Breast Cancer
Texas Tech University Health Sciences Center
 June 1 2022 Phase 1|Phase 2
NCT05073523 Completed
Healthy
Chalmers University of Technology
 September 27 2021 Not Applicable
NCT05367024 Enrolling by invitation
Pre-diabetes
Quadram Institute Bioscience|Norfolk and Norwich University Hospitals NHS Foundation Trust
 September 27 2021 Not Applicable

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