Sulforaphane

Catalog No.S5771

For research use only.

Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis.

Sulforaphane Chemical Structure

CAS No. 4478-93-7

Selleck's Sulforaphane has been cited by 5 Publications

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Biological Activity

Description Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and NF-κB. Sulforaphane increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). Sulforaphane induces cell cycle arrest and apoptosis.
Targets
Nrf2 [1]
()
HDAC [1]
()
NF-κB [1]
()
ROS [1]
()
HO-1 [1]
()
Assay
Methods Test Index PMID
Western blot β-catenin / Cyclin D1 ; EGFR / p-EGFR / STAT3 / p-STAT3 / AKT / p-AKT 20388854 26036303
Growth inhibition assay Cell viability 30226534
Immunofluorescence HER2 ; Gli1 / Gli2 30226534 23029396

Protocol (from reference)

Chemical Information

Molecular Weight 177.29
Formula

C6H11NOS2

Density 1.17 g/mL
CAS No. 4478-93-7
Storage 2 years -20°C(in the dark) liquid
Smiles CS(=O)CCCCN=C=S

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03934905 Not yet recruiting Drug: sulforaphane|Drug: Placebo Oral Tablet Anthracycline Related Cardiotoxicity in Breast Cancer Texas Tech University Health Sciences Center January 1 2022 Phase 1|Phase 2
NCT05073523 Recruiting Other: Diet Healthy Chalmers University of Technology September 27 2021 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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