Naringenin

For research use only.

Catalog No.S2394 Synonyms: NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol

7 publications

Naringenin Chemical Structure

CAS No. 480-41-1

Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.

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Selleck's Naringenin has been cited by 7 publications

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  • (d) Antiviral activity of SZA on assembly and release. Huh7 cells were electroporated with JFH-1 RNA of HCV, followed by 4 h treatment of the indicated concentrations of SZA. At 48 h after electroporation, cells were subjected to three cycles of freeze and thaw to test the intracellular viral infectivity; supernatants of the electroporated cells were collected for the detection of extracellular viral infectivity. 100 μM naringenin was introduced as a positive control. Results are shown as relative HCV infectivity compared to DMSO treated group. Data shown as mean ± SD of three independent experiments.

    Scientific Reports 6, 2016, Article number: 27268 . Naringenin purchased from Selleck.

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Biological Activity

Description Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.
Targets
CYP1A2 [1]
In vitro

Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. Naringenin is the predominant flavanone in grapefruit. This substance has also been shown to reduce oxidative damage to DNA in vitro. Naringenin found in grapefruit juice has been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2, which can change pharmacokinetics in a human (or orthologous) host of several popular agents in an adverse manner, even resulting in carcinogens of otherwise harmless substances. [1]

In vivo Intragastrically administered Naringenin (50 mg/kg) induces a significant decrease in plasma glucose in normoglycaemic and non-insulin-dependent diabetes mellitus (NIDDM) rat models. LD50: Mice >5g/kg; Rats >5g/kg. [2]

Protocol

Solubility (25°C)

In vitro DMSO 54 mg/mL (198.34 mM)
Ethanol 5 mg/mL (18.36 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 272.25
Formula

C15H12O5

CAS No. 480-41-1
Storage powder
in solvent
Synonyms NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol
Smiles C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O

In vivo Formulation Calculator (Clear solution)

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04731987 Recruiting Behavioral: Beverage consumption Metabolic Syndrome|Vascular Compliance|Predisposition to Cardiovascular Disease University Hospital Clermont-Ferrand|UMR 1019 Unité de Nutrition Humaine INRAE Auvergne-Rhône Alpes Center|Department of Beverage Research Chair of analysis and technology of plant-based foods Geisenheim University|European Fruit Juice Association (AIJN) February 24 2021 Not Applicable
NCT03582553 Completed Dietary Supplement: Naringenin|Other: Placebo Safety Issues|Pharmacokinetics Pennington Biomedical Research Center|Louisiana Clinical and Translational Science Center May 25 2018 Early Phase 1
NCT03032861 Completed Other: Orange juice Intestinal Diseases São Paulo State University September 2016 Not Applicable
NCT02380144 Unknown status Other: Fresh orange fruit and pasteurized fruit juice Healthy University of Hohenheim January 2014 Not Applicable
NCT02627547 Completed Behavioral: Normal training|Behavioral: De-training Healthy University of Glasgow September 2013 Not Applicable

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P450 (e.g. CYP17) Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID