For research use only.
Catalog No.S2394 Synonyms: NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol
CAS No. 480-41-1
Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.
Selleck's Naringenin has been cited by 7 publications
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(d) Antiviral activity of SZA on assembly and release. Huh7 cells were electroporated with JFH-1 RNA of HCV, followed by 4 h treatment of the indicated concentrations of SZA. At 48 h after electroporation, cells were subjected to three cycles of freeze and thaw to test the intracellular viral infectivity; supernatants of the electroporated cells were collected for the detection of extracellular viral infectivity. 100 μM naringenin was introduced as a positive control. Results are shown as relative HCV infectivity compared to DMSO treated group. Data shown as mean ± SD of three independent experiments.
Scientific Reports 6, 2016, Article number: 27268 . Naringenin purchased from Selleck.
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|Description||Naringenin (NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol) is a natural predominant flavanone derived from plant food, which is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator.|
Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. Naringenin is the predominant flavanone in grapefruit. This substance has also been shown to reduce oxidative damage to DNA in vitro. Naringenin found in grapefruit juice has been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2, which can change pharmacokinetics in a human (or orthologous) host of several popular agents in an adverse manner, even resulting in carcinogens of otherwise harmless substances. 
|In vivo||Intragastrically administered Naringenin (50 mg/kg) induces a significant decrease in plasma glucose in normoglycaemic and non-insulin-dependent diabetes mellitus (NIDDM) rat models. LD50: Mice >5g/kg; Rats >5g/kg. |
|In vitro||DMSO||54 mg/mL (198.34 mM)|
|Ethanol||5 mg/mL (18.36 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||NSC 34875, S-Dihydrogenistein, NSC 11855, Salipurol|
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04731987||Recruiting||Behavioral: Beverage consumption||Metabolic Syndrome|Vascular Compliance|Predisposition to Cardiovascular Disease||University Hospital Clermont-Ferrand|UMR 1019 Unité de Nutrition Humaine INRAE Auvergne-Rhône Alpes Center|Department of Beverage Research Chair of analysis and technology of plant-based foods Geisenheim University|European Fruit Juice Association (AIJN)||February 24 2021||Not Applicable|
|NCT03582553||Completed||Dietary Supplement: Naringenin|Other: Placebo||Safety Issues|Pharmacokinetics||Pennington Biomedical Research Center|Louisiana Clinical and Translational Science Center||May 25 2018||Early Phase 1|
|NCT03032861||Completed||Other: Orange juice||Intestinal Diseases||São Paulo State University||September 2016||Not Applicable|
|NCT02380144||Unknown status||Other: Fresh orange fruit and pasteurized fruit juice||Healthy||University of Hohenheim||January 2014||Not Applicable|
|NCT02627547||Completed||Behavioral: Normal training|Behavioral: De-training||Healthy||University of Glasgow||September 2013||Not Applicable|
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