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Methyl Dihydrojasmonate

Cat.No.S5139

Methyl dihydrojasmonate (Hedione, Kharismal) is a flavouring ingredien with the smell vaguely similar to jasmin.
Methyl Dihydrojasmonate Chemical Structure

Chemical Structure

Molecular Weight: 226.31

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Quality Control

Batch: S513901 Purity: 98%
98

Solubility

In vitro
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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 226.31 Formula

C13H22O3

 Storage (From the date of receipt) 2 years  -20°C  liquid
CAS No. 24851-98-7 -- Storage of Stock Solutions

Mechanism of Action

In vitro
Methyl dihydrojasmonate inhibits the growth of leukemia cells as well as lung, breast, and prostate cancer cells. It opens the mitocondrial permeability transition-pore complex, allowing cytochrome C release and induction of apoptosis, and the expression of reactive oxygen species. Jasmonate-derivative compounds, including jasmonic acid (JA) and methyl dihydrojasmonate (MJ), also induces the suppression of cell proliferation in human and mouse cancer cell lines, such as prostate cancer and breast cancers, melanoma, leukemia, lymphoid, and myeloid.
In vivo
Methyl dihydrojasmonate (MDHJ) is a promising anti-cancer drug of a plant origin (jasmine plant). Jasmonate-derivative compounds are poorly water-soluble, and cannot be administered intravenously or adequately absorbed by the body. The oral LD50 of Methyl dihydrojasmonate in rats exceeds 5.0 g/kg. By the dermal route, the rabbit LD50 also exceeds 5.0 g/kg. By the intraperitoneal route in ICR mice, the LD50 is 1397.2 mg/kg. While in rats, an intraperitoneal injection of Methyl dihydrojasmonate in corn oil produces clinical signs at 1000 mg/kg and mortality at 2000 mg/kg. Methyl dihydrojasmonate is not considered to possess a mutagenic or genotoxic potential.
References

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