Orotic acid (6-Carboxyuracil)

Catalog No.S2336

For research use only.

Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid.

Orotic acid (6-Carboxyuracil) Chemical Structure

CAS No. 65-86-1

Purity & Quality Control

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Biological Activity

Description Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 156.1


CAS No. 65-86-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=C(NC(=O)NC1=O)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02110147 Completed Drug: uridine triacetate Hereditary Orotic Aciduria Wellstat Therapeutics April 2014 Phase 3
NCT00843921 Unknown status Drug: N-carbamylglutamate Inborn Errors of Metabolism Mendel Tuchman|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Children''s National Research Institute August 2008 Phase 2|Phase 3

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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